Gestational Trophoblast Disease

  • Bradley Bigelow

Abstract

The somewhat awkward title of this final chaper on placental pathology is a reflection of the age-old difficulty in understanding the pathogenesis and predicting the behavior of a very fascinating group of gestational abnormalities. Three conditions are included: hydatidiform mole, invasive mole (chorioadenoma destruens), and choriocarcinoma. They run the gamut from degenerative to neoplastic processes. Although connecting links between them are demonstrable, both in clinical situations and in the laboratory, the unpredictability persists despite years of observation and analysis.

Keywords

Hydatidiform Mole Gestational Trophoblast Disease Molar Pregnancy Trophoblastic Tumor Gestational Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bagshawe, K. D. Trophoblastic tumors. Chemotherapy and development. Br. Med. J. 2: 1303, 1963.CrossRefGoogle Scholar
  2. 2.
    Bagshawe, K. D. Hydatidiform mole and choriocarcinoma. Br. Med. J. 1: 1509, 1966.CrossRefGoogle Scholar
  3. 3.
    Barkla, P. C. Hydatidiform mole and chorioepithelioma. J. Obstet. Gynaecol. Br. Emp. 62: 239, 1955.CrossRefGoogle Scholar
  4. 4.
    Bore11, U. Hydatidiform mole diagnosed by pelvic angiography. Acta. Radiol. 56: 113, 1961.CrossRefGoogle Scholar
  5. 5.
    Brewer, J. I., and Gerbie, A. B. Early development of choriocarcinoma. Am. J. Obstet. Gynecol. 94: 692, 1966.Google Scholar
  6. 6.
    Cockshott, W. P., Evans, K. T. E., and De V. Hendrikse, J. P. Arteriography of trophoblastic tumors. Clin. Radiol. 15: 1, 1964.CrossRefGoogle Scholar
  7. 7.
    Coppleson, M. Hydatidiform mole and its complications. J. Obstet. Gynaecol. Br. Emp. 65: 238, 1958.CrossRefGoogle Scholar
  8. 8.
    Corscaden, J. A., and Shettles, L. B. Hydatidiform mole and choriocarcinoma. Bull. Sloane Hosp. Women 5: 41, 1959.Google Scholar
  9. 9.
    Donald, I., and Brown, T. G. Localization using physical devices, radioisotopes and radiologic methods. I. Demonstration of tissue interfaces within the body by ultrasonic echo sounding Br. J. Radiol. 34: 539, 1961.Google Scholar
  10. 10.
    Douglas, G. W. The diagnosis and management of hydatidiform mole. Surg. Clin. North Am. 37: 379, 1957.PubMedGoogle Scholar
  11. 11.
    Douglas, G. W. Malignant change in trophoblastic tumors. Am. J. Obstet. Gynecol. 84: 884, 1962.Google Scholar
  12. 12.
    Editorial: The fetus as a homograft. Lancet II: 535, 1975.Google Scholar
  13. 13.
    Girouard, D. P., Barclay, D. L., and Collins, C. G. Hyperreactio luteinalis. Obstet. Gynecol. 23: 513, 1964.Google Scholar
  14. 14.
    Goldstein, D. P., and Kosasa, T. S. The subunit radioimmunoassay for HCG-Clinical application, in M. L. Taymor and T. H. Green, Jr., eds.: Progress in Gynecology. Grune and Stratton, 1975, Vol. VI, pp. 145–184.Google Scholar
  15. 15.
    Grady, H. G. Hydatidiform mole and choriocarcinoma. Ann. N.Y. Acad. Sci. 75: 565, 1959.Google Scholar
  16. 16.
    Green, R. R. Chorioadenoma destruens. Ann. N.Y. Acad. Sci. 80: 143, 1959.CrossRefGoogle Scholar
  17. 17.
    Harper, W. F., and McVicar, J. Hydatidiform mole and pregnancy diagnosed by sonar. Br. Med. J. 2: 1178, 1963.CrossRefGoogle Scholar
  18. 18.
    Hertig, A. T., and Edmonds, H. W. Genesis of hydatidiform mole. Arch. Pathol. 30: 260, 1940.Google Scholar
  19. 19.
    Hertig, A. T., and Mansell, H. Tumors of the female sex organs. Part I. Hydatidiform mole and choriocarcinoma. Washington, D.C., Armed Forces Institute of Pathology, 1956.Google Scholar
  20. 20.
    Hertig, A. T., and Sheldon, W. H. Hydatidiform mole-A pathologico-clinical correlation of 200 cases. Am. J. Obstet. Gynecol. 53: 1, 1947.Google Scholar
  21. 21.
    Hilgers, R. D., and Lewis, J. L. Jr. Gestational trophoblastic neoplasms. Gynecol. Oncol. 2: 460, 1974.PubMedCrossRefGoogle Scholar
  22. 22.
    Jones, W. B., and Lauersen, N. H. Hydatidiform mole with coexistent fetus. Am. J. Obstet. Gynecol. 122: 267, 1975.Google Scholar
  23. 23.
    Klingen, H. P. Points from the discussion in W. M. Davidson and D. R. Smith, eds.: Human Chromosomal Abnormalities. Proceedings. London, 1959. London Staples Press, 1961, p. 130.Google Scholar
  24. 24.
    Klingen, H. P., and Atkin, N. B. Sex chromatin studies on hydatidiform moles. Hum. Chromosome Newsletter 3: 18, 1961.Google Scholar
  25. 25.
    Li, M. C., Hertz, R., and Spencer, D. B. Effect of methotrexate therapy upon choriocarcinoma and chorioadenoma. Proc. Soc. Exp. Biol. Med. 93: 361, 1956.PubMedGoogle Scholar
  26. 26.
    McVicar, J. Illustrative examples of ultrasonic echograms. Proc. R. Soc. Med. 55: 638, 1962.Google Scholar
  27. 27.
    Meyer, A. W. Hydatidiform degeneration in tubal pregnancy. Surg. Gynecol. Obstet. 28: 293, 1919.Google Scholar
  28. 28.
    Nilsson, L. Hydatidiform degeneration in aborted ova. A histopathologic and clinical study. Acta Obstet. Gynecol. Scand. 36 (Suppl. 7): 1, 1957.Google Scholar
  29. 29.
    Ober, W. B., Edgcomb, J. H., and Price, E. B. The pathology of choriocarcinoma. Ann. N.Y. Acad. Sci. 172: 299, 1971.Google Scholar
  30. 30.
    Park, W. W. Choriocarcinoma. A Study of Its Pathology. Philadelphia, F. A. Davis Co., 1971.Google Scholar
  31. 31.
    Szulman, A. E. Chromosomal aberrations in spontaneous human abortions. N. Engl. J. Med. 272: 811, 1965.Google Scholar

Copyright information

© Springer Science+Business Media New York 1977

Authors and Affiliations

  • Bradley Bigelow

There are no affiliations available

Personalised recommendations