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Pathology of the Female Genital Tract pp 586–626Cite as

Ovarian Neoplasms of Childhood and Adolescence

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Abstract

Ovarian neoplasms occurring in children and adolescents during the first two decades of life comprise a very special group of lesions. They are special not because of any major histologic differences in types of neoplasms as compared with those of adults, but because of the clinical and therapeutic implications. In the treatment of these young patients it is essential that whenever possible ovarian tissue be preserved in order to insure future normal physical development and child-bearing potential. However, it is equally essential that the malignant neoplasms be appropriately eradicated. Too often, in the past, children and young women have been unnecessarily castrated on the basis that an ovarian tumor in this age group, particularly when solid, is malignant and requires radical surgery. It is mandatory that ovarian neoplasms in children and adolescents be accurately classified and their natural history clearly understood.

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References

  1. Abell, M. R. The nature and classification of ovarian neoplasms. Can. Med. Assoc. J. 94: 1102, 1966.

    PubMed  CAS  Google Scholar 

  2. Abell, M. R. Undifferentiated malignant germ cell neoplasm (embryonal carcinoma) of ovary with stromal luteinization and masculinization. Am. J. Obstet. Gynecol. 101: 570, 1968.

    CAS  Google Scholar 

  3. Abell, M. R., and Holtz, F. Ovarian neoplasms in childhood and adolescence. II. Tumors of non-germ cell origin. Am. J. Obstet. Gynecol. 93: 850, 1965.

    PubMed  CAS  Google Scholar 

  4. Abell, M. R., Johnson, V. J., and Holtz, F. Ovarian neoplasms in childhood and adolescence. I. Tumors of germ cell origin. Am. J. Obstet. Gynecol. 92: 1059, 1965.

    CAS  Google Scholar 

  5. Abitbol, M. M., Pomerance, W., and Mackles, A. Spontaneous intraperitoneal rupture of benign cystic teratomas. Review of literature and report of two cases. Obstet. Gynecol. 13: 198, 1959.

    PubMed  CAS  Google Scholar 

  6. Adair, F. L., and Watts, R. M. A study of the hormonal content of ovarian cyst fluids. Am. J. Obstet. Gynecol. 34: 799, 1937.

    Google Scholar 

  7. Allibone, E. C., and Collins, D. H. Symptomatic haemolytic anaemia associated with ovarian teratoma in a child. J. Clin. Pathol. 4: 412, 1951.

    CAS  Google Scholar 

  8. Anderson, W. R., Levine, A. J., and MacMillan, D. Granulosa-theca cell tumors: Clinical and pathologic study. Am. J. Ob-stet. Gynecol. 110: 32, 1971.

    CAS  Google Scholar 

  9. Asadourian, L. A., and Taylor, H. B. Dysgerminoma. An analysis of 105 cases. Obstet. Gynecol. 33: 370, 1969.

    PubMed  CAS  Google Scholar 

  10. Azoury, R. S., and Woodruff, J. D. Primary ovarian sarcomas. Report of 43 cases from the Emil Novak Ovarian Tumor Registry. Obstet. Gynecol. 37: 920, 1971.

    PubMed  CAS  Google Scholar 

  11. Ballas, M. Yolk sac carcinoma of the ovary with alpha fetoprotein in serum and ascitic fluid demonstrated by immunoosmophoresis. Am. J. Clin. Pathol. 57: 511, 1972.

    CAS  Google Scholar 

  12. Barber, H. R. K., and Graber, E. A. Gynecological tumors in childhood and adolescence. Obstet. Gynecol. Surv. 28 (Suppl): 357, 1973.

    PubMed  Google Scholar 

  13. Barry, K. G., and Crosby, W. H. Auto-immune hemolytic anemia arrested by removal of an ovarian teratoma: Review of the literature and report of a case. Ann. Int. Med. 47: 1002, 1957.

    PubMed  CAS  Google Scholar 

  14. Benirschke, K., Easterday, C., and Abramson, D. Malignant solid teratoma of the ovary. Report of three cases. Obstet. Gynecol. 15: 512, 1960.

    CAS  Google Scholar 

  15. Berendsen, P. B., Smith, E. B., Abell, M. R., and Jaffe, R. B. Fine structure of Leydig cells from an arrhenoblastoma of the ovary. Am. J. Obstet. Gynecol. 103: 192, 1969.

    CAS  Google Scholar 

  16. Berlin, N. I., Van Scott, E. J., Clendenning, W. E., et al. Basal cell nevus syndrome. Combined clinical staff conference at the National Institutes of Health. Ann. Int. Med. 64: 403, 1966.

    PubMed  CAS  Google Scholar 

  17. Bernstein, D., Naor, S., Rikover, M., and Menahem, H. Hemolytic anemia related to ovarian tumor. Obstet. Gynecol. 43: 276, 1974.

    PubMed  CAS  Google Scholar 

  18. Biskind, G. R., and Biskind, M. S. Experimental ovarian tumors in rats. Am. J. Clin. Pathol. 19: 501, 1949.

    CAS  Google Scholar 

  19. Biskind, M. S., and Biskind, G. R. Development of tumors in the rat ovary after transplantation into the spleen. Proc. Soc. Exp. Biol. Med. 55: 176, 1944.

    CAS  Google Scholar 

  20. Boivin, Y., and Richart, R. M. Hilus cell tumors of the ovary. A review with a report of 3 new cases. Cancer 18: 231, 1965.

    PubMed  CAS  Google Scholar 

  21. Breen, J. L., and Neubecker, R. D. Malignant teratoma of the ovary. An analysis of 17 cases. Obstet. Gynecol. 21: 669, 1963.

    CAS  Google Scholar 

  22. Brentnall, C. P. A case of arrhenoblastoma complicating pregnancy. J. Obstet. Gynaecol. Br. Emp. 52: 235, 1945.

    Google Scholar 

  23. Brew, D. StJ., and Jackson, J. G. Lymphosarcoma in the ovary in young African girls in Nigeria. Br. J. Cancer 14: 621, 1960.

    CAS  Google Scholar 

  24. Brune, W. H., Pulaski, E. J., and Shuey, H. E. Giant ovarian cyst. Report of a case in a premature infant. N. Engl. J. Med. 257: 876, 1957.

    CAS  Google Scholar 

  25. Burkitt, D., and O’Conor, G. T. Malignant lymphoma in African children. I. A clinical syndrome. Cancer 14: 258, 1961.

    PubMed  CAS  Google Scholar 

  26. Burslem, R. W., Langley, F. A., and Woodcock, A. S. A clinicopathological study of oestrogenic ovarian tumors. Cancer 7: 522, 1954.

    PubMed  CAS  Google Scholar 

  27. Busby, T., and Anderson, G. W. Feminizing mesenchymomas of the ovary. Includes 107 cases of granulosa-, granu-losa-theca-cell, and theca-cell tumors. Am. J. Obstet. Gynecol. 68: 1391, 1954.

    PubMed  CAS  Google Scholar 

  28. Canelo, C. K., and Lisser, H. A case of arrhenoblastoma which simulated Cushing’s disease. Endocrinology 24: 838, 1939.

    Google Scholar 

  29. Case records of the Massachusetts General Hospital. Case 13–1970. Edited by B. Castleman. N. Engl. J. Med. 282:676, 1970.

    Google Scholar 

  30. Caspi, E., Schreyer, P., and Bukovsky, J. Ovarian lutein cysts in pregnancy. Obstet. Gynecol. 42: 388, 1973.

    Google Scholar 

  31. Chalvardjian, A., and Scully, R. E. Sclerosing stromal tumors of the ovary. Cancer 31: 664, 1973.

    PubMed  CAS  Google Scholar 

  32. Charache, H. Ovarian tumors in childhood. Report of six new cases and review of the literature. Arch. Surg. 79: 573, 1959.

    CAS  Google Scholar 

  33. Christian, C. D. Ovarian tumors: An extension of the Peutz-Jeghers syndrome. Am. J. Obstet. Gynecol. 111: 529, 1971.

    CAS  Google Scholar 

  34. Cianfrani, T. Neoplasms in apparently normal ovaries. Am. J. Obstet. Gynecol. 51: 246, 1946.

    CAS  Google Scholar 

  35. Cocco, A. E., and Conway, S. J. Zollinger-Ellison Syndrome associated with ovarian mucinous cystadenocarcinoma. N. Eng. J. Med. 293: 485, 1975.

    CAS  Google Scholar 

  36. Costin, M. E. Jr., and Kennedy, R. L. J. Ovarian tumors in infants and children. Am. J. Dis. Child. 76: 127, 1948.

    Google Scholar 

  37. Croft, P. B., and Wilkinson, M. The incidence of carcinomatous neuromyopathy in patients with various types of carcinoma. Brain 88: 427, 1965.

    PubMed  CAS  Google Scholar 

  38. Cruikshank, D. P., and Chapler, F. K. Arrhenoblastomas and associated ovarian pathology. Obstet. Gynecol. 43: 539, 1974.

    CAS  Google Scholar 

  39. Damjanov, I., Drobnjak, P., Grizelj, V., and Longhino, N. Sclerosing stromal tumor of the ovary. A hormonal and ultra-structural analysis. Obstet. Gynecol. 45: 675, 1975.

    Google Scholar 

  40. Davies, J. N. P. Cancer in Africa. in D. H. Collins, ed., Modern Trends in Pathology. Butterworth and Co., London, 1958.

    Google Scholar 

  41. Della Porta, G. Induction of intestinal, mammary, and ovarian tumors in hamsters with oral administration of 20-methylcholanthrene. Cancer Res. 21: 575, 1961.

    Google Scholar 

  42. Denny-Brown, D. Primary sensory neuropathy with muscular changes associated with carcinoma. J. Neurol. Neurosurg. Psychiatry. 11: 73, 1948.

    CAS  Google Scholar 

  43. Dorfman, R. I. Steroid hormones in gynecology. Obstet. Gynecol. Surv. 18: 65, 1963.

    Google Scholar 

  44. Ehrlich, E. N., Dominguez, O. V., Samuels, L. T., Lynch, D., Oberhelman, H. Jr., and Warner, N. E. Aldosteronism and precocious puberty due to an ovarian androblastoma (Sertoli cell tumor). J. Clin. Endocrinol. 23: 358, 1963.

    CAS  Google Scholar 

  45. Ein, S. H. Malignant ovarian tumors in children. J. Pediatr. Surg. 8: 539, 1973.

    CAS  Google Scholar 

  46. Ein, S. H., Darte, J. M. M., and Stephens, C. A. Cystic and solid ovarian tumors in children; a 44-year review. J. Pediatr. Surg. 5: 148, 1970.

    PubMed  CAS  Google Scholar 

  47. Esterhay, R. J., Shapiro, H. M., Sutherland, J. C., McIntire, K. R., and Wiernik, P. H. Serum alpha fetoprotein concentration and tumor growth dissociation in a patient with ovarian teratocarcinoma. Cancer 31: 835, 1973.

    PubMed  Google Scholar 

  48. Falin, L. I. The development of genital glands and the origin of germ cells in human embryogenesis. Acta Anat. 72: 195, 1969.

    PubMed  CAS  Google Scholar 

  49. Favara, B. E., and Franciosi, R. A. Ovarian teratoma and neuroglial implants on the peritoneum. Cancer 31: 678, 1973.

    PubMed  CAS  Google Scholar 

  50. Feld, D., Labes, J., and Nathanson, M. Bilateral ovarian dermoid cysts in triplets. Obstet. Gynecol. 27: 525, 1966.

    Google Scholar 

  51. Ferenczy, A., Okagaki, T., and Richart, R. M. Para-endocrine hypercalcemia in ovarian neoplasms. Report of meso nephroma with hypercalcemia and review of literature. Cancer 27: 427, 1971.

    PubMed  CAS  Google Scholar 

  52. Flick, F. H., and Banfield, R. S. Jr. Malignant theca-cell tumors. Two new case reports and review of the eight published cases. Cancer 9: 731, 1956.

    PubMed  Google Scholar 

  53. Forney, J. P., Di Saia, P. J., and Morrow, C. P. Endodermal sinus tumor. A report of two sustained remissions treated postoperatively with a combination of actinomycin D, 5-fluorouracil, and cyclophosphamide. Obstet. Gynecol: 45: 186, 1975.

    CAS  Google Scholar 

  54. Fortt, R. W., and Mathie, I. K. Gliomatosis peritonei caused by ovarian teratoma. J. Clin. Pathol. 22: 348, 1969.

    PubMed  CAS  Google Scholar 

  55. Furth, J., and Butterworth, J. S. Neoplastic diseases occurring among mice subjected to general irradiation with x-rays. II. Ovarian tumors and associated lesions. Am. J. Cancer 28: 66, 1936.

    Google Scholar 

  56. Gardner, W. U. Some studies on ovarian tumorigenesis, in G. E. W. Wolstenholme and M. O’Connor, CIBA Foundation Colloquia on Endocrinology, Vol. 12. Hormone Production in Endocrine Tumours. Little Brown and Co., Boston, 1958, pp. 153172.

    Google Scholar 

  57. Gerbie, M. V., Brewer, J. I., and Tamimi, H. Primary choriocarcinoma of the ovary. Obstet. Gynecol. 46: 720, 1975.

    PubMed  CAS  Google Scholar 

  58. Gillman, J. The development of the gonads in man, with a consideration of the role of fetal endocrines and the histogenesis of ovarian tumors. Contrib. Embryo]. Carnegie Inst. 32: 81, 1948.

    Google Scholar 

  59. Gondos, B., and Monroe, S. A. Cystic granulosa cell tumor with massive hemoperitoneum Light and electron microscopic study. Obstet. Gynecol. 38: 683, 1971.

    CAS  Google Scholar 

  60. Gonzalez-Angulo, A., Kaufman, R. H., Braungardt, C. D., Chapman, F. C., and Hinshaw, A. J. Adenocarcinoma of thyroid arising in struma ovarii (malignant struma ovarii). Report of two cases and review of the literature. Obstet. Gynecol. 21: 567, 1963.

    CAS  Google Scholar 

  61. Goodall, C. M. On para-endocrine cancer syndromes: A review. Int. J. Cancer 4: 1, 1969.

    Google Scholar 

  62. Gordon, T., Crittenden, M., and Haenszel, W. Cancer mortality trends in the United States, 1930–1955, in, United States National Cancer Institute: End Results and Mortality Trends in Cancer, Monograph No. 6, Washington, D.C., 1961, p. 131.

    Google Scholar 

  63. Gough, A. A case of disgerminoma of the ovary associated with masculinity. J. Obstet. Gynaecol. Br. Emp. 45: 799, 1938.

    Google Scholar 

  64. Groeber, W. R. Ovarian tumors during infancy and childhood. Am. J. Obstet. Gynecol. 86: 1027, 1963.

    Google Scholar 

  65. Hain, A. M. An unusual case of precocious puberty associated with ovarian dysgerminoma. J. Clin. Endocrinol. 9: 1349, 1949.

    CAS  Google Scholar 

  66. Heald, F. P., Craig, J. M., and Ming, P.-M. L. Ovarian tumors in adolescence: Types and presenting features. Clin. Pediatr. 6: 401, 1967.

    Google Scholar 

  67. Henderson, D. N. Granulosa and theca cell tumors of the ovary: With a report of thirty cases. Am. J. Obstet. Gynecol. 43: 194, 1942.

    Google Scholar 

  68. Hertig, A. T., and Gore, H. Tumors of the ovary and fallopian tube, in Tumors of the Female Sex Organs, Atlas of Tumor Pathology, Fasc. 33, Part 3. Washington, D.C., Armed Forces Institute of Pathology, 1961.

    Google Scholar 

  69. Hesseltine, H. C., and Smith, R. L. Ovarian malignancy. Am. J. Obstet. Gynecol. 72: 1326, 1956.

    CAS  Google Scholar 

  70. Hodgson, J. E., Dockerty, M. B., and Mussey, R. D. Granulosa cell tumor of the ovary. A clinical and pathologic review of sixty-two cases. Surg. Gynecol. Obstet. 81: 631, 1945.

    CAS  Google Scholar 

  71. Holt, G. W. Idiopathic neuropathy in cancer. A first sign in multiple system syndromes associated with malignancy. Am. J. Med. Sci. 242: 93, 1961.

    CAS  Google Scholar 

  72. Howell, J. S., Marchant, J., and Orr, J. W. The induction of ovarian tumours in mice with 9:10-dimethyl-1:2-benzanthracene. Br. J. Cancer 8: 635, 1954.

    PubMed  CAS  Google Scholar 

  73. Huntington, R. W. Jr., and Bullock, W. K. Yolk sac tumors of the ovary. Cancer 25: 1357, 1970.

    PubMed  Google Scholar 

  74. James, D. F., Barber, H. R. K., and Graber, E. A. Torsion of normal uterine adnexa in children. Report of three cases. Obstet. Gynecol. 35: 226, 1970.

    CAS  Google Scholar 

  75. Javert, C. T., and Finn, W. F. Arrhenoblastoma. The incidence of malignancy and the relationship to pregnancy, to sterility, and to treatment. Cancer 4: 60, 1951.

    PubMed  CAS  Google Scholar 

  76. Jensen, R. D., and Norris, H. J. Epithelial tumors of the ovary. Occurrence in children and adolescents less than 20 years of age. Arch. Pathol. 94: 29, 1972.

    PubMed  CAS  Google Scholar 

  77. Jensen, R. D., Norris, H. J., and Fraumeni, J. F. Jr. Familial arrhenoblastoma and thyroid adenoma. Cancer 33: 218, 1974.

    PubMed  CAS  Google Scholar 

  78. Kalstone, C. E., Jaffe, R. B., and Abell, M. R. Massive edema of the ovary simulating fibroma. Obstet. Gynecol. 34: 564, 1969.

    Google Scholar 

  79. Kase, N. Steroid synthesis in abnormal ovaries. II. Granulosa cell tumor. Am. J. Obstet. Gynecol. 90: 1262, 1964.

    CAS  Google Scholar 

  80. Kay, S., Silverberg, S. G., and Schatzki, P. F. Ultrastructure of an ovarian dysgerminoma: Report of a case featuring neurosecretory-type granules in stromal cells. Am. J. Clin. Pathol. 58: 458, 1972.

    PubMed  CAS  Google Scholar 

  81. Kelley, R. R., and Scully, R. E. Cancer developing in dermoid cysts of the ovary. A report of 8 cases, including a carcinoid and a leiomyosarcoma. Cancer 14: 989, 1961.

    PubMed  CAS  Google Scholar 

  82. Kempers, R. D., Dockerty, M. B., Hoffman, D. L., and Bartholomew, L. G. Struma ovarii-Ascitic, hyperthyroid, and asymptomatic syndromes. Ann. Int. Med. 72: 883, 1970.

    PubMed  CAS  Google Scholar 

  83. Kimmel, G. C. Sexual precocity and accelerated growth in a child with a follicular cyst of the ovary. J. Pediatr. 30: 686, 1947.

    PubMed  CAS  Google Scholar 

  84. Kistner, R. W. Intraperitoneal rupture of benign cystic teratomas. Review of the literature with a report of two cases. Obstet. Gynecol. Surv. 7: 603, 1952.

    CAS  Google Scholar 

  85. Kleinsmith, L. J., and Pierce, G. B. Jr. Multipotentiality of single embryonal carcinoma cells. Cancer Res. 24: 1554, 1964.

    Google Scholar 

  86. Kunstadter, R. H., Schultz, A., and Strauss, A. A. Large ovarian cyst in a newborn infant. Am. J. Dis. Child. 80: 993, 1950.

    CAS  Google Scholar 

  87. Kurrein, F., and Fothergill, R. J. Oleo-keratin granuloma in peritoneum: A rare complication of ovarian dermoid. J. Obstet. Gynaecol. Br. Commonw. 68: 124, 1961.

    PubMed  CAS  Google Scholar 

  88. Li, F. P., Fraumeni, J. F. Jr., and Dalager, N. Ovarian cancers in the young. Epidemiologic observations. Cancer 32: 969, 1973.

    PubMed  CAS  Google Scholar 

  89. Li, F. P., Rapoport, A. H., Fraumeni, J. F. Jr., and Jensen, R. D. Familial ovarian carcinoma. J. Am. Med. Assoc. 214: 1559, 1970.

    CAS  Google Scholar 

  90. Lieberman, J. S., Borrero, J., Urdaneta, E., and Wright, I. S. Thrombophlebitis and cancer. J. Am. Med. Assoc. 177: 542, 1961.

    CAS  Google Scholar 

  91. Liebert, K. I., and Stent, L. Dysgerminoma of the ovary with chorion-epithelioma. J. Obstet. Gynaecol. Br. Emp. 67: 627, 1960.

    CAS  Google Scholar 

  92. Lindfors, O. Primary ovarian neoplasms in infants and children. A study of 81 cases diagnosed in Finland and Sweden. Ann. Chir. Gynaecol. Fenn. 60:12, 1971, Suppl. 177.

    Google Scholar 

  93. Lipsett, M. B., Odell, W. D., Rosenberg, L. E., and Waldmann, T. A. Humoral syndromes associated with nonendocrine tumors. Ann. Int. Med. 61: 733, 1964.

    CAS  Google Scholar 

  94. Lyon, F. A., Sinykin, M. B., and McKelvey, J. L. Granulosa-cell tumors of the ovary. Review of 23 cases. Obstet. Gynecol. 21: 67, 1963.

    CAS  Google Scholar 

  95. MacAulay, M. A., Weliky, I., and Schulz, R. A. Ultrastructure of a biosynthetically active granulosa cell tumor. Lab. Invest. 17: 562, 1967.

    Google Scholar 

  96. Mackinlay, C. J. Male cells in granulosa cell tumours. J. Obstet. Gynaecol. Br. Emp. 64: 512, 1957.

    CAS  Google Scholar 

  97. Mann, L. S., and Metrick, S. Hemangioma of the ovary. Report of a case. J. Int. Coll. Surg. 36: 500, 1961.

    CAS  Google Scholar 

  98. Marrubini, G. Primary chorionepithelioma of the ovary. Report of two cases. Acta Obstet. Gynaecol. Scand. 28: 251, 1949.

    CAS  Google Scholar 

  99. Masopust, J., Kithier, K., Radl, J., Koutecky, J., and Kotal, L. Occurrence of fetoprotein in patients with neoplasms and nonneoplastic diseases. Int. J. Cancer 3: 364, 1968.

    PubMed  CAS  Google Scholar 

  100. Masson, P. Sur la présence de cellules argentaffines dans les kystes pseudomucineux de l’ovaire. Union Med Canada 67: 2, 1938.

    Google Scholar 

  101. McAndrew, G. M. Haemolytic anaemia associated with ovarian teratoma. Br. Med. J. 2: 1307, 1964.

    CAS  Google Scholar 

  102. McGoldrick, J. L., and Lapp, W. A. Theca-cell tumors of the ovary. Am. J. Obstet. Gynecol. 48: 409, 1944.

    Google Scholar 

  103. McKay, D. G., Hertig, A. T., Adams, E. C., and Danziger, S. Histochemical observations on the germ cells of human embryos. Anat. Rec. 117: 201, 1953.

    PubMed  CAS  Google Scholar 

  104. Melicow, M. M., and Uson, A. C. Dysgenetic gonadomas and other gonadal neoplasms in intersexes. Report of 5 cases and review of the literature. Cancer 12: 552, 1959.

    PubMed  CAS  Google Scholar 

  105. Mengert, W. F. Precocious puberty due to an ovarian cyst in a five-year-old girl. Am. J. Obstet. Gynecol. 37: 485, 1939.

    Google Scholar 

  106. Mintz, B. Formation and early development of germ cells. Symposium on the Germ Cells and Earliest Stages of Development. Milan, Fondazione A Baselli Instituto Lombardo, 1961.

    Google Scholar 

  107. Mueller, C. W., Topkins, P., and Lapp, W. A. Dysgerminoma of the ovary: An analysis of 427 cases. Am. J. Obstet. Gyne-, col. 60: 153, 1950.

    CAS  Google Scholar 

  108. Neigus, I. Ovarian dysgerminoma with chorionepithelioma: Report of a case. Am. J. Obstet. Gynecol. 69: 838, 1955.

    PubMed  CAS  Google Scholar 

  109. Neikirk, W. I., and Hudson, H. W. Jr. Giant ovarian cyst in a newborn infant. N. Engl. J. Med. 239: 468, 1948.

    CAS  Google Scholar 

  110. Neubecker, R. D., and Breen, J. L. Embryonal carcinoma of the ovary. Cancer 15: 546, 1962.

    PubMed  CAS  Google Scholar 

  111. Nichols, J., Warren, J. C., and Mantz, F. A. ACTH-like excretion from carcinoma of the ovary. The clinical effect of m, p’-DDD. J. Am. Med. Assoc. 182: 713, 1962.

    CAS  Google Scholar 

  112. Norris, H. J., and Jensen, R. D. Relative frequency of ovarian neoplasms in children and adolescents. Cancer 30: 713, 1972.

    PubMed  CAS  Google Scholar 

  113. Novak, E. R., Kutchmeshgi, J., Mupas, R. S., and Woodruff, J. D. Feminizing gonadal stromal tumors. Analysis of the granulosa-theca cell tumors of the ovarian tumor registry. Obstet. Gynecol. 38: 701, 1971.

    CAS  Google Scholar 

  114. O’Conor, G. T. Malignant lymphoma in African children. II. A pathological entity. Cancer 14: 270, 1961.

    PubMed  Google Scholar 

  115. O’Hern, T. M., and Neubecker, R. D. Arrhenoblastoma. Obstet. Gynecol. 19: 758, 1962.

    PubMed  Google Scholar 

  116. Omenn, G. S., Roth, S. I., and Baker, W. H. Hyperparathyroidism associated with malignant tumors of nonparathyroid origin. Cancer 24: 1004, 1969.

    PubMed  CAS  Google Scholar 

  117. O’Neill, R. T., and Mikuta, J. J. Hypoglycemia associated with serous cystadenocarcinoma of the ovary. Obstet. Gynecol. 35: 287, 1970.

    Google Scholar 

  118. Pantoja, E., Rodriguez-Ibanez, I., Axtmayer, R. W., Noy, M. A., and Pelegrina, I. Complications of dermoid tumors of the ovary. Obstet. Gynecol. 45: 89, 1975.

    Google Scholar 

  119. Papadaki, L., and Beilby, J. O. W. Ovarian cystadenofibroma: A consideration of the role of estrogen in its pathogenesis. Am. J. Obstet. Gynecol. 121: 501, 1975.

    PubMed  CAS  Google Scholar 

  120. Pedersen, J., and Homburger, C. Virilizing Leydig cell tumour of the ovary. Report of a case with special reference to the hormone excretion. Acta Endocrinol. 13: 109, 1953.

    PubMed  CAS  Google Scholar 

  121. Pedowitz, P., Felmus, L. B., and Mackles, A. Precocious pseudopuberty due to ovarian tumors. Obstet. Gynecol. Surv. 10: 633, 1955.

    CAS  Google Scholar 

  122. Pedowitz, P., and O’Brien, F. B. Arrhenoblastoma of the ovary. Review of the literature and report of 2 cases. Obstet. Gynecol. 16: 62, 1960.

    PubMed  CAS  Google Scholar 

  123. Peterson, W. F. Malignant degeneration of benign cystic teratomas of the ovary. A collective review of the literature. Obstet. Gynecol. Surv. 12: 793, 1957.

    CAS  Google Scholar 

  124. Peterson, W. F., Prevost, E. C., Edmunds, F. T., Hundley, J. M. Jr., and Morris, F. K. Benign cystic teratomas of the ovary: A clinico-statistical study of 1,007 cases with a review of the literature. Am. J. Obstet. Gynecol. 70: 368, 1955.

    CAS  Google Scholar 

  125. Pierce, G. B. Jr., Dixon, F. J. Jr., and Verney, E. L. Teratocarcinogenic and tissue-forming potentials of the cell types comprising neoplastic embryoid bodies. Lab. Invest. 9: 583, 1960.

    Google Scholar 

  126. Pinkerton, J. H. M., McKay, D. G., Adams, E. C., and Hertig, A. T. Development of the human ovary—A study using histochemical technics. Obstet. Gynecol. 18: 152, 1961.

    Google Scholar 

  127. Robboy, S. J., and Scully, R. E. Ovarian teratoma with glial implants on the peritoneum. Hum. Pathol. 1: 643, 1970.

    CAS  Google Scholar 

  128. Rubin, I. C., Novak, J., and Squire, J. J. Ovarian fibromas and theca-cell tumors: Report of 78 cases with special reference to production of ascites and hydrothorax (Meigs’ syndrome). Am. J. Obstet. Gynecol. 48: 601, 1944.

    Google Scholar 

  129. Santesson, L., and Marrubini, G. Clinical and pathological survey of ovarian embryonal carcinomas, including so-called “mesonephromas” (Schiller), or “mesoblastomas” (Teilum), treated at the radiumhemmet. Acta Obstet. Gynecol. Scand. 36: 399, 1957.

    CAS  Google Scholar 

  130. Schaeffer, M. H., and Cancelmo, J. J. Cavernous hemangioma of ovary in a girl twelve years of age. Am. J. Obstet. Gynecol. 38: 722, 1939.

    Google Scholar 

  131. Schmeisser, H. C., and Anderson, W. A. D. Ganglioneuroma of the ovary. J. Am. Med. Assoc. 111: 2005, 1938.

    Google Scholar 

  132. Schuler, D., and Juhasz, J. Choriocarcinoma in a female infant. Ann. Paediatr. (Basel) 195: 56, 1960.

    CAS  Google Scholar 

  133. Schultz, L. R., Newton, W. A. Jr., and Clatworthy, H. W. Jr. Torsion of previously normal tube and ovary in children. N. Engl. J. Med. 268: 343, 1963.

    PubMed  CAS  Google Scholar 

  134. Scully, R. E. Gonadoblastoma. A gonadal tumor related to the dysgerminoma (seminoma) and capable of sex-hormone production. Cancer 6: 455, 1953.

    PubMed  CAS  Google Scholar 

  135. Scully, R. E. Recent progress in ovarian cancer. Hum. Pathol. 1: 73, 1970.

    PubMed  CAS  Google Scholar 

  136. Scully, R. E. Gonadoblastoma. A review of 74 cases. Cancer 25: 1340, 1970.

    PubMed  CAS  Google Scholar 

  137. Shane, J. M., and Naftolin, F. Aberrant hormone activity of tumors of gynecologic importance. Amer. J. Obstet. Gynecol. 121: 133, 1975.

    CAS  Google Scholar 

  138. Stein, I. F. Sr., and Kaye, B. M. Granulomatous peritonitis secondary to perforation of dermoid cyst. Am. J. Obstet. Gynecol. 67: 155, 1954.

    Google Scholar 

  139. Steiner, M. M., and Hadawi, S. A. Sexual precocity. Association with follicular cysts of ovary. Am. J. Dis. Child. 108: 28, 1964.

    CAS  Google Scholar 

  140. Sturley, R. F. Teratomatous chorionepithelioma of the ovary. Critical review of literature, with report of a new case. Minn. Med. 25: 629, 1942.

    Google Scholar 

  141. Talerman, A., and Haije, W. G. Alpha-fetoprotein and germ cell tumors: A possible role of yolk sac tumor in production of alpha-fetoprotein. Cancer 34: 1722, 1974.

    PubMed  CAS  Google Scholar 

  142. Tancer, M. L., Orron, A., Baker, J. D., and Greenberger, M. E. Spontaneous rupture of ovarian teratoid tumor (dermoid cyst) into the urinary bladder: Review of eleven cases and report of one new case. Obstet. Gynecol. 6: 668, 1955.

    PubMed  CAS  Google Scholar 

  143. Teter, J. A new concept of classification of gonadal tumours arising from germ cell (gonocytoma) and their histogenesis. Gynaecologia 150: 84, 1960.

    PubMed  CAS  Google Scholar 

  144. Thatcher, D. S. Ovarian cysts and tumors in children. Surg. Gynecol. Obstet. 117: 477, 1963.

    CAS  Google Scholar 

  145. Thompson, J. P., Dockerty, M. B., Symmonds, R. E., and Hayles, A. B. Ovarian and parovarian tumors in infants and children. Am. J. Obstet. Gynecol. 97: 1059, 1967.

    PubMed  CAS  Google Scholar 

  146. Thurlbeck, W. M., and Scully, R. E. Solid teratoma of the ovary. A clinicopathological analysis of 9 cases. Cancer 13: 804, 1960.

    PubMed  CAS  Google Scholar 

  147. Traut, H. F., and Marchetti, A. A. A consideration of so-called “granulosa” and “theca” cell tumors of the ovary. Surg. Gynecol. Obstet. 70: 632, 1940.

    Google Scholar 

  148. Trites, A. E. W. Benign cystic ovarian teratomas of childhood or “ovarian hydrocephalus”. Canad. Med. Assoc. J. 84: 606, 1961.

    CAS  Google Scholar 

  149. Usizima, H. Ovarian dysgerminoma associated with masculinization. Report of a case. Cancer 9: 736, 1956.

    PubMed  CAS  Google Scholar 

  150. Waisman, J., Lischke, J. H., Mwasi, L. M., and Dignam, W. J. The ultrastructure of a feminizing granulosa-theca tumor. Am. J. Obstet. Gynecol. 123: 147, 1975.

    CAS  Google Scholar 

  151. Warren, J. C., Erkman, B., and Cheatum, S. Hilus-cell adenoma in a dysgenetic gonad with XX/XO mosaicism. Lancet 1: 141, 1964.

    Google Scholar 

  152. White, C. A., and Bradbury, J. T. Ovarian theca lutein cysts. Experimental formation in women prior to repeat cesarean section. Am. J. Obstet. Gynecol. 92: 973, 1965.

    CAS  Google Scholar 

  153. Wilkinson, E. J., Friedrich, E. G., and Hosty, T. A. Alphafetoprotein and endodermal sinus tumor of the ovary. Am. J. Obstet. Gynecol. 116: 711, 1973.

    CAS  Google Scholar 

  154. Williams, R. C. Jr. Dermatomyositis and malignancy: A review of the literature. Ann. Int. Med. 50: 1174, 1959.

    Google Scholar 

  155. Wisniewski, M., and Deppisch, L. M. Solid teratomas of the ovary. Cancer 32: 440, 1973.

    PubMed  CAS  Google Scholar 

  156. Wits chi, E. Migration of the germ cells to human embryos from the yolk sac to the primitive gonadal folds. Contrib. Embryol. Carnegie Inst. 32: 67, 1948.

    Google Scholar 

  157. Woodruff, J. D., Noll Castillo, R. D., and Novak, E. R. Lymphoma of the ovary. A study of 35 cases from Ovarian Tumor Registry of the American Gynecological Society. Am. J. Obstet. Gynecol. 85: 912, 1963.

    CAS  Google Scholar 

  158. Woodruff, J. D., Protos, P., and Peterson, W. F. Ovarian teratomas. Relationship of histologic and ontogenic factors to prognosis. Am. J. Obstet. Gynecol. 102: 702, 1968.

    CAS  Google Scholar 

  159. Zangeneh, F., and Kelley, V. C. Granulosa-theca cell tumor of the ovary in children. Am. J. Dis. Child. 115: 494, 1968.

    CAS  Google Scholar 

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  1. M. R. Abell M.D., Ph.D.
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  1. New York University School of Medicine, New York, New York, USA

    Ancel Blaustein (Clinical Professor of Pathology) (Clinical Professor of Pathology)

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Abell, M.R. (1977). Ovarian Neoplasms of Childhood and Adolescence. In: Blaustein, A. (eds) Pathology of the Female Genital Tract. Springer, New York, NY. https://doi.org/10.1007/978-1-4757-6143-6_27

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  • DOI: https://doi.org/10.1007/978-1-4757-6143-6_27

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