Sex Cord-Stromal Tumors

  • Robert E. Scully

Abstract

This category of ovarian tumors includes all those that contain granulosa cells, theca cells and their luteinized derivatives, Sertoli cells, Leydig cells, and fibroblasts of gonadal stromal origin, singly or in several combinations and in varying degrees of differentiation. The generic terms that have been most widely applied to these tumors reflect differing views of gonadal embryology. Those investigators who are convinced that all the cell types listed above, including granulosa and Sertoli cells, are derived from the mesenchyme or “specialized stroma” of the genital ridge have proposed the terms mesenchymomas3 and gonadal stromal tumors for these neoplasms.24,27 In contrast, others, recognizing that embryologists disagree on the role of the coelomic epithelium in the formation of the sex cords which are the proximal precursors of the granulosa and Sertoli cells, prefer to leave open the possibility that these cell types are ultimately derived from the coelomic epithelium and have favored the term sex cordmesenchyme tumors20,36 or sex cord—stromal tumors.40 In the developing testis the sex cords are clearly distinguishable by the fifth.

Keywords

Granulosa Cell Sertoli Cell Leydig Cell Theca Cell Granulosa Cell Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Berlin, N. I., Van Scott, E. J., Glendenning, W. E., Archard, H. O., Block, J. B., Witkop, C. J., and Haynes, H. A. Basal cell nevus syndrome. Ann. Intern. Med. 64: 403, 1966.CrossRefGoogle Scholar
  2. 2.
    Burslem, R. W., Langley, F. A., and Woodcock, A. S. A clinicopathological study of oestrogenic ovarian tumours. Cancer 7: 552, 1954.CrossRefGoogle Scholar
  3. 3.
    Busby, T., and Anderson, G. W. Feminizing mesenchymomas of the ovary. Am. J. Obstet. Gynecol. 68: 1391, 1954.Google Scholar
  4. 4.
    Case Records of the Massachusetts General Hospital. Case 24, 1971. N. Engl. J. Med. 284: 1369, 1971.Google Scholar
  5. 5.
    Chalvardjian, A., and Scully, R. E. Sclerosing stromal tumors of the ovary. Cancer 31: 664, 1973.PubMedCrossRefGoogle Scholar
  6. 6.
    Dickersin, G. R., and Scully, R. E. The juvenile granulosa cell tumor. Report of 20 cases and review of the literature. In preparation, 1976.Google Scholar
  7. 7.
    Dockerty, M. B., and MacCarty, W. C. Granulosa cell tumors; with the report of a 34-lb. specimen and a review. Am. J. Obstet. Gynecol. 37: 425, 1939.Google Scholar
  8. 8.
    Fathalla, M. F. The occurrence of granulosa and theca tumors in clinically normal ovaries. A study of 25 cases. J. Obstet. Gynaecol. Br. Commonw. 74: 279, 1967.CrossRefGoogle Scholar
  9. 9.
    Fathalla, M. F. The role of the ovarian stroma in hormone production by ovarian tumors. J. Obstet. Gynaecol. Br. Commonw. 75: 78, 1968.PubMedCrossRefGoogle Scholar
  10. 10.
    Fox, H., Agrawal, K., and Langley, F. A. A clinicopathologic study of 92 cases of granulosa cell tumor of the ovary with special reference to the factors influencing prognosis. Cancer 35: 231, 1975.PubMedCrossRefGoogle Scholar
  11. 11.
    Gusberg, S. B., and Kardon, P. Proliferative endometrial response to theca-granulosa cell tumors. Am. J. Obstet. Gynecol. 111: 633, 1971.Google Scholar
  12. 12.
    Iturzaeta, N., Kenny, F. M., and Sieber, W. Precocious pseudopuberty due to granulosa cell tumor in three girls. Am. J. Dis. Child. 114: 39, 1967.Google Scholar
  13. 13.
    Johnston, W. W., Goldston, W. R., and Montgomery, M. S. Clinicopathologic studies in feminizing tumors of the ovary. III. The role of genital cytology. Acta Cytol. 15: 334, 1971.PubMedGoogle Scholar
  14. 14.
    Jolly, H. Sexual Precocity. A Personal Study of 69 Patients. American Lecture Series, Springfield, Ill., Charles C Thomas, 1955.Google Scholar
  15. 15.
    Judd, H. L., Spore, W. W., Talner, L. B., Rigg, L. A., Yen, S. S. C., and Benirschke, K. Preoperative localization of a testosterone-secreting ovarian tumor by retrograde venous catherization and selective sampling. Am. J. Obstet. Gynecol. 120: 91, 1974.PubMedGoogle Scholar
  16. 16.
    Kalstone, C. E., Jaffe, R. B., and Abell, M. R. Massive edema of the ovary simulating fibroma. Obstet. Gynecol. 34: 564, 1969.PubMedGoogle Scholar
  17. 17.
    Kottmeier, H. L. Carcinoma of the Female Genitalia. The Abraham Flexner Lectures, Series No. 11, Baltimore, Williams and Wilkins, 1953.Google Scholar
  18. 18.
    Malkasian, G. D. Jr., Webb, M. J., and Jorgensen, E. O. Observations on chemotherapy of granulosa cell carcinomas and malignant ovarian teratomas. Obstet. Gynecol. 44: 885, 1974.Google Scholar
  19. 19.
    Meigs, J. V. Fibroma of the ovary with ascites and hydrothorax. Meigs’ syndrome. Am. J. Obstet. Gynecol. 67: 962, 1954.Google Scholar
  20. 20.
    Morris, J. McL., and Scully, R. E. Endocrine Pathology of the Ovary. St. Louis, C. V. Mosby Co., 1958, 151 p.Google Scholar
  21. 21.
    Morrison, C. W., and Woodruff, J. D. Fibrothecoma and associated ovarian stromal neoplasia. Obstet. Gynecol. 23: 344, 1964.PubMedGoogle Scholar
  22. 22.
    Mostofi, F. K., and Price, E. B. Jr. Tumors of the male genital system. Atlas of Tumor Pathology, Second Series, Fascicle 8. Washington, D.C., Armed Forces Institute of Pathology, 1973.Google Scholar
  23. 23.
    Niswander, K. R., Courey, N. G., and Woodward, T. Precocious pseudopuberty caused by ovarian tumors. Obstet. Gynecol. 26: 381, 1965.PubMedGoogle Scholar
  24. 24.
    Norris, H. J., and Charlton, I. Functioning tumors of the ovary. Clin. Obstet. Gynecol. 17: 189, 1974.CrossRefGoogle Scholar
  25. 25.
    Norris, H. J., and Taylor, H. B. Prognosis of granulosa-theca tumors of the ovary. Cancer 21: 255, 1968.PubMedCrossRefGoogle Scholar
  26. 26.
    Norris, H. J., and Taylor, H. B. Virilization associated with cystic granulosa tumors. Obstet. Gynecol. 34: 629, 1969.Google Scholar
  27. 27.
    Novak, E. R., Kutchmeshgi, J., Mupas, R. S., and Woodruff, J. D., et al. Feminizing gonadal stromal tumors. Obstet. Cynecol. 38: 701, 1971.Google Scholar
  28. 28.
    Novak, E. R., and Long, J. H. Arrhenoblastoma of the ovary. Am. J. Obstet. Gynecol. 92: 1082, 1965.Google Scholar
  29. 29.
    O’Hern, T. M., and Neubecker, R. D. Arrhenoblastoma. Obstet. Gynecol. 19: 758, 1962.PubMedGoogle Scholar
  30. 30.
    Osborn, R. H., and Yannone, M. E. Plasma androgens in the normal and androgenic female: A review. Obstet. Gynecol. Surv. 26: 195, 1971.CrossRefGoogle Scholar
  31. 31.
    Prunty, F. T. G. Hirsutism, virilism and apparent virilism and their gonadal relationship. Part 1. J. Endocrinol. 38: 85, 1967.PubMedCrossRefGoogle Scholar
  32. 32.
    Roth, L. M., and Sternberg, W. H. Ovarian stromal tumors containing Leydig cells. II. Pure Leydig cell tumor, non-hilar type. Cancer 32: 952, 1973.PubMedCrossRefGoogle Scholar
  33. 33.
    Samanth, K. K., and Black, W. C. Benign ovarian stromal tumors associated with free peritoneal fluid. Am. J. Obstet. Gynecol. 107: 538, 1970.Google Scholar
  34. 34.
    Scully, R. E. Androgenic lesions of the ovary. In Grady, H. G., and Smith, D. E., eds. The Ovary. International Academy of Pathology Monograph No. 3, Baltimore, Williams and Wilkins, 1962, pp. 143–174.Google Scholar
  35. 35.
    Scully, R. E. Stromal luteoma of the ovary. A distinctive type of lipoid-cell tumor. Cancer 17: 769, 1964.PubMedCrossRefGoogle Scholar
  36. 36.
    Scully, R. E. Sex cord-mesenchyme tumours. Pathologic classification and its relation to prognosis and treatment. In Junqueira, A. C., and Gentil, F., eds. Ovarian Cancer. IUCC Monograph Series, Vol. II. Heidelberg, Springer-Verlag, 1968, pp. 40–56.Google Scholar
  37. 37.
    Scully, R. E. Sex cord tumor with annular tubules. A distinctive ovarian tumor of the Peutz-Jeghers syndrome. Cancer 25: 1107, 1970.PubMedCrossRefGoogle Scholar
  38. 38.
    Scully, R. E. Gonadoblastoma. A review of 74 cases. Cancer 25: 1340, 1970.PubMedCrossRefGoogle Scholar
  39. 39.
    Serment, H. L., Laffargue, P., Piana, L., and Blanc, B. Ovarian hormone tumors of female children. Int. J. Gynaecol. Obstet. 8: 409, 1970.Google Scholar
  40. 40.
    Serov, S. F., Scully, R. E., and Sobin, L. H. International Histological Classification of Tumours, No. 9. Histological Typing of Ovarian Tumours. Geneva, World Health Organization, 1973.Google Scholar
  41. 41.
    Sjostedt, S., and Wahlen, T. Prognosis of granulosa cell tumors. Acta Obstet. Gynecol. Scand. 40: 1, 1961.Google Scholar
  42. 42.
    Smith, J. P., and Rutledge, F. Chemotherapy in the treatment of cancer of the ovary. Am. J. Obstet. Gynecol. 107: 691, 1970.Google Scholar
  43. 43.
    Sotto, L. S. J., Postoloff, A. V., and Carr, F. A case of calcified ovarian fibroma with ossification. Am. J. Obstet. Gyne-col. 71: 1355, 1956.Google Scholar
  44. 44.
    Sternberg, W. H. The morphology, endocrine function, hyperplasia and tumors of the human ovarian-hilus cells. Am. J. Pathol. 25: 493, 1949.PubMedGoogle Scholar
  45. 45.
    Sternberg, W. H., and Roth, L. M. Ovarian stromal tumors containing Leydig cells. 1. Stromal-Leydig cell tumor and nonneoplastic transformation of ovarian stroma to Leydig cells. Can-cer 32: 940, 1973.Google Scholar
  46. 46.
    Targett, C. S. Estrogen excretion in a case of theca-granulosa cell tumor. Am. J. Obstet. Gynecol. 119: 859, 1974.Google Scholar
  47. 47.
    Taylor, H. B., and Norris, H. J. Lipid cell tumors of the ovary. Cancer 20: 1953, 1967.PubMedCrossRefGoogle Scholar
  48. 48.
    Teilum, G. Classification of testicular and ovarian androblastoma and Sertoli cell tumors. Cancer 11: 769, 1958.PubMedCrossRefGoogle Scholar
  49. 49.
    Teilum, G. Special Tumors of Ovary and Testis. Comparative Pathology and Histological Identification. Philadelphia, Lippincott, 1971.Google Scholar

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© Springer Science+Business Media New York 1977

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  • Robert E. Scully

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