Sex Cord-Stromal Tumors

  • Robert E. Scully


This category of ovarian tumors includes all those that contain granulosa cells, theca cells and their luteinized derivatives, Sertoli cells, Leydig cells, and fibroblasts of gonadal stromal origin, singly or in several combinations and in varying degrees of differentiation. The generic terms that have been most widely applied to these tumors reflect differing views of gonadal embryology. Those investigators who are convinced that all the cell types listed above, including granulosa and Sertoli cells, are derived from the mesenchyme or “specialized stroma” of the genital ridge have proposed the terms mesenchymomas3 and gonadal stromal tumors for these neoplasms.24,27 In contrast, others, recognizing that embryologists disagree on the role of the coelomic epithelium in the formation of the sex cords which are the proximal precursors of the granulosa and Sertoli cells, prefer to leave open the possibility that these cell types are ultimately derived from the coelomic epithelium and have favored the term sex cordmesenchyme tumors20,36 or sex cord—stromal tumors.40 In the developing testis the sex cords are clearly distinguishable by the fifth.


Granulosa Cell Sertoli Cell Leydig Cell Theca Cell Granulosa Cell Tumor 
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© Springer Science+Business Media New York 1977

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  • Robert E. Scully

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