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Human Papillomaviruses and Cancer: A Retrospective

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Abstract

The discovery in the second part of the last century of bacteria as causative agents of numerous contagious diseases, including anthrax, diphtheria, typhoid fever and plague, and a widespread disease of high morbidity and mortality—tuberculosis (whose infectious origin had been disputed at that time), created an atmosphere of expectations. This led to the anticipation that even other diseases without epidemiological evidence for an infectious etiology, as for example, cancer and rheumatic fever, may also be caused by infections.

Modified from of a review article: Roots and perspectives of contemporary papillomavirus research. J Cancer Res Clin Oncol 1996; 122:3–13.

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References

  1. Iwanowski D. Über die Mosaikkrankheit der Tabakpflanze. Bull Acad Imp Sci St Petersburg 1894; 3 (35): 67–70.

    Google Scholar 

  2. Beijerinck MW. Über ein Contagium vivum fluidum als Ursache der Fleckenkrankheit der Tabakblätter. Verhandl. Koninkl Akad Wetenschappen te Amsterdam 1898; 6: 3–22.

    Google Scholar 

  3. McFadyan J, Hobday F. Note on the experimental “transmission of warts in the dog”. J Comp Pathol Ther 1898; 11: 341–349.

    Google Scholar 

  4. Ciuffo G. Innesto positivo con filtrado di verrucae volgare. G Ital Mal Venereol 1907; 48: 12–18.

    Google Scholar 

  5. Rowson KEK, Mahy BWJ. Human papova (wart) virus. Bacteriol Rev 1967; 31: 110–131.

    PubMed  CAS  Google Scholar 

  6. Shope RE. Infectious papillomatosis of rabbits. J Exp Med 1933; 58: 607–627.

    Article  PubMed  CAS  Google Scholar 

  7. Rous P, Beard JW. Carcinomatous changes in virus-induced papillomas of the skin of the rabbit. Proc Soc Exp Biol Med 1934; 32: 578–580.

    Google Scholar 

  8. Rous P, Beard JW. The progression to carcinoma of virus-induced rabbit papilloma (Shope). J Exp Med 1935; 62: 523–548.

    Article  PubMed  CAS  Google Scholar 

  9. Syverton JT, Berry GP. Carcinoma in the cottontail rabbit following spontaneous virus papilloma (Shope). Proc Soc Exp Biol Med 1935; 33: 300–400.

    Google Scholar 

  10. Rous P, Kidd JG. The carcinogenic effect of a papillomavirus on the tarred skin of rabbits. I. Description of the phenomenon. J Exp Med 1938; 67: 399–422.

    Article  PubMed  CAS  Google Scholar 

  11. Rous P, Friedewald WF. The effect of chemical carcinogens on virus-induced rabbit papillomas. J Exp Med 1944; 79: 511–537.

    Article  PubMed  CAS  Google Scholar 

  12. Strauss MJ, Shaw EW, Bunting H et al. “Crystalline” virus-like particles from skin papillomas characterized by intranuclear inclusion bodies. Proc Soc Exp Biol Med 1949; 72: 46–50.

    PubMed  CAS  Google Scholar 

  13. Crawford LV, Crawford EM. A comparative study of polyoma and papilloma viruses. Virology 1963; 21: 258–263.

    Article  PubMed  CAS  Google Scholar 

  14. Ito Y, Evans CA. Induction of tumors in domestic rabbits with nucleic acid preparations from partially purified Shope papilloma virus and from extracts of the papillomas of domestic and cotton tail rabbits. J Exp Med 1961; 114: 485–491.

    Article  PubMed  CAS  Google Scholar 

  15. Han RF, Breitburd F, Marche PN et al. Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Nature 1992; 356: 66–68.

    Article  PubMed  CAS  Google Scholar 

  16. Zeltner R, Borenstein LA, Wettstein FO et al. Changes in RNA expression pattern during malignant progression of cottontail rabbit papillomavirus-induced tumors in rabbits. J Virol 1994; 68: 3620–2630.

    PubMed  CAS  Google Scholar 

  17. Lin YL, Borenstein LA, Ahmed R et al. Cottontail rabbit papillomavirus L1 protein-based vaccines: protection is achieved only with a full-length, nondenatured product. J Virol 1993; 67: 4154–4163.

    PubMed  CAS  Google Scholar 

  18. Breitburd F, Kirnbauer R, Hubbert NL et al. Immunization with virus-like particles from cottontail rabbit papillomavirus (CRPV) can protect against experimental CRPV infection. J Virol 1995; 69: 3959–3963.

    PubMed  CAS  Google Scholar 

  19. Magelhaes O. Verruga dos bovideos. Brasil-Medico 1920; 34: 430–431.

    Google Scholar 

  20. Olson C, Cook RH. Cutaneous sarcoma-like lesions of the horse induced by the agent of bovine papilloma. Proc Soc Exp Biol Med 1951; 77: 281–284.

    PubMed  Google Scholar 

  21. Olson C, Pamukcu AM, Brobst DF et al. A urinary bladder tumor induced by a bovine cutaneous papilloma agent. Cancer Res 1959; 19: 779–782.

    PubMed  CAS  Google Scholar 

  22. Friedmann JC, Levy JP, Lasnaret J et al. Induction de fibromes sous-cutanés chez le hamster doré par inoculation d’extrait acellulaires de papillomes bovins et leur transformation maligne par greffes isologues. Compt Rend Acad Sci (Paris) 1963; 257: 2328–2331.

    CAS  Google Scholar 

  23. Boiron M, Levy JP, Thomas M et al. Some properties of bovine papilloma virus. Nature 1964; 201: 423–424.

    Article  PubMed  CAS  Google Scholar 

  24. Black PH, Hartley JW, Rowe WP et al. Transformation of bovine tissue culture cells by bovine papilloma virus. Nature 1963; 199: 1016–1018.

    Article  PubMed  CAS  Google Scholar 

  25. Thomas M, Levy JP, Tanzer J et al. Transformation in vitro de cellules de peau de veau embryonnaire sous l’action d’extraits acellulaires de papillomes bovins. Compt Rend Acad Sci (Paris) 1963; 257: 2155–2158.

    CAS  Google Scholar 

  26. Lancaster WD, Olson C. Demonstration of two distinct classes of bovine papilloma virus. Virology 1978; 89: 371–379.

    Article  Google Scholar 

  27. Lowy DR, Dvoretzky I, Shober R et al. In vitro tumorigenic transformation by a defined subgenomic fragment of bovine papilloma virus DNA. Nature 1980; 287: 72–74.

    Article  PubMed  CAS  Google Scholar 

  28. Chen EY, Howley PM, Levinson AD et al. The primary structure and genetic organization of the bovine papillomavirus (BPV) type 1 genome. Nature 1982; 299: 529–534.

    Article  PubMed  CAS  Google Scholar 

  29. Jarrett WFH. Bracken fern and papilloma virus in bovine alimentary cancer. Brit Med Bull 1980; 36: 79–81.

    PubMed  CAS  Google Scholar 

  30. Almeida JD, Goffe AP. Antibody to wart virus in human sera demonstrated by electron microscopy and precipitin tests. Lancet 1965; 2: 1205–1207.

    Article  PubMed  CAS  Google Scholar 

  31. zur Hausen H, Meinhof W, Scheiber W et al. Attempts to detect virus-specific DNA sequences in human tumors: I. Nucleic acid hybridizations with complementary RNA of human wart virus. Int J Cancer 1974; 13: 650–656.

    Article  PubMed  Google Scholar 

  32. zur Hausen H, Schulte-Holthausen H, Wolf H et al. Attempts to detect virus-specific DNA in human tumors: II. Nucleic acid hybridizations with complementary RNA of human herpes group viruses. Int J Cancer 1974; 13: 657–664.

    Article  PubMed  Google Scholar 

  33. Gissmann L, zur Hausen H. Human papilloma viruses: physical mapping and genetic heterogeneity. Proc Nat Acad Sci USA 1976; 73: 1310–1313.

    Article  PubMed  CAS  Google Scholar 

  34. Gissmann L, Pfister H, zur Hausen H. Human papilloma viruses (HPV): Characterization of four different isolates. Virology 1977; 76: 569–580.

    Article  PubMed  CAS  Google Scholar 

  35. Orth G, Favre M, Croissant O. Characterization of a new type of human papillomavirus that causes skin warts. J Virol 1977; 24: 108–120.

    PubMed  CAS  Google Scholar 

  36. Coggin JR, zur Hausen H. Workshop on papilloma viruses and cancer. Cancer Res 1978; 39: 545–546.

    Google Scholar 

  37. de Villiers EM. Human pathogenic papillomaviruses: An update. In: zur Hausen H, ed. Current Topics in Microbiology and Immunology. Berlin-Heidelberg: Springer Verlag, 1994; 86: 1–12.

    Google Scholar 

  38. Shamanin V, Glover M, Rausch C et al. Specific types of human papillomavirus found in benign proliferations and carcinomas of the skin in immunosuppressed patients. Cancer Res 1994; 54: 4610–4613.

    PubMed  CAS  Google Scholar 

  39. Van Ranst M, Fuse A, Fiten P et al. Human papillomavirus type 13 and pygmy chimpanzee papillomavirus type 1: comparison of the genome organizations. Virology 1992; 190: 587–596.

    Article  PubMed  Google Scholar 

  40. Bernard HU, Chan SY, Delius H. Evolution of papillomaviruses. Curr Topics Microbiol Immunol 1994; 186: 33–54.

    Article  CAS  Google Scholar 

  41. Lewandowsky F, Lutz W. Ein Fall einer bisher nicht beschriebenen Hauterkrankung (Epidermodysplasia verruciformis). Arch Dermatol Syph (Berlin) 1922; 141: 193–203.

    Google Scholar 

  42. Schellender F, Fritsch F. Epidermodysplasia verruciformis. Neue Aspekte zur Symptomatologie und Pathogenese. Dermatologica 1970; 140: 251–259.

    Article  Google Scholar 

  43. Ruiter M and van Mullem PJ. Behaviour of virus in malignant degeneration of skin lesions in epidermodysplasia verruciformis. J Invest Dermatol 1970; 54: 324–331.

    Article  PubMed  CAS  Google Scholar 

  44. Jablonska S, Dabrowski J, Jakubowicz K. Epidermodysplasia verruciformis as a model in studies on the role of papovaviruses in oncogenesis. Cancer Res 1972; 32: 583–589.

    PubMed  CAS  Google Scholar 

  45. Lutzner MA. Epidermodysplasia verruciformis. An autosomal recessive disease characterized by viral warts and skin cancer. Bull Cancer Paris 1978; 65: 169–182.

    PubMed  CAS  Google Scholar 

  46. Lutz W. A propos de l’epidermodysplasie verruciforme. Dermatologica 1946; 92: 30–43.

    Article  PubMed  CAS  Google Scholar 

  47. Jablonska S, Millewski B. Zur Kenntnis der Epidermodysplasia verruciformis Lewandowsky-Lutz. Dermatologica 1957; 115: 1–22.

    Article  PubMed  CAS  Google Scholar 

  48. Ruiter M, van Mullem PJ. Demonstration by electronmicroscopy of an intranuclear virus in epidermodysplasia verruciformis. J Invest Dermatol 1966 Sep; 47 (3): 247–52.

    PubMed  CAS  Google Scholar 

  49. Yabe Y, Okamoto T, Okmori S et al. Virus particles in epidermodysplasia verruciformis with carcinoma. Dermmatologica 1969; 139: 161–164.

    Article  CAS  Google Scholar 

  50. Delescluse C, Prunieras M, Regnier M et al. Epidermodysplasia verruciformis. I. Electron microscope autoradiography and tissue culture studies. Arch Dermatol Forsch 1972; 242: 202–215.

    Article  PubMed  CAS  Google Scholar 

  51. Orth G, Jablonska S, Jarzabek-Chorzelska M et al. Characteristics of the lesions and risk of malignant conversion as related to the type of the human papillomavirus involved in epidermodysplasia verruciformis. Cancer Res 1979; 39: 1074–1082.

    PubMed  CAS  Google Scholar 

  52. Preston DS, Stern RS. Nonmelanoma cancers of the skin. New Engl J Med 1992; 327: 1649–1662.

    Article  PubMed  CAS  Google Scholar 

  53. Rees J. Genetic alterations in nonmelanoma skin cancer. J. Invest Dermatol 1994; 103: 747–750.

    Article  PubMed  CAS  Google Scholar 

  54. Lutzner MA, Orth G, Dutronquay V et al. Detection of human papillomavirus type 5 DNA in skin cancers of an immunosuppressed renal allograft recipient. Lancet 1983; 2: 422–424.

    Article  PubMed  CAS  Google Scholar 

  55. Obalek S, Favre M, Szymanczyk J et al. Human papillomavirus (HPV) types specific of epidermodysplasia verruciformis in warts induced by HPV 3 or HPV3-related types in immunosuppressed patients. J Invest Dermatol 1992; 98: 936–941.

    Article  PubMed  CAS  Google Scholar 

  56. Van der Leest RJ, Zachow KR, Ostrow RS et al. Human papillomavirus heterogeneity in 36 renal transplant recipients. Arch Dermatol 1986; 123: 354–357.

    Google Scholar 

  57. Euvrard S, Chardonnet Y, Pouteil-Noble C et al. Association of skin malignancies with various and multiple carcinogenic and noncarcinogenic human papillomaviruses in renal transplant recipients. Cancer 1993; 72: 2198–2206.

    Article  PubMed  CAS  Google Scholar 

  58. Stark LA, Arends MJ, McLaren KM et al. Prevalence of human papillomavirus DNA in cutaneous neoplasms from renal allograft recipients supports a possible viral role in tumor promotion. Brit J Cancer 1994; 69: 222–229.

    Article  PubMed  CAS  Google Scholar 

  59. Barr BB, Benton EC, McLaren K et al. Human papilloma virus infection and skin cancer in renal allograft recipients. Lancet 1989; 1: 124–129.

    Article  PubMed  CAS  Google Scholar 

  60. Purdie KJ, Sexton CJ, Proby CM et al. Malignant transformation of cutaneuos lesions in renal allograft patients: a role for human papillomavirus. Cancer Res 1993; 53: 5328–5333.

    PubMed  CAS  Google Scholar 

  61. Soler C, Chardonnet Y, Allibert P et al. Detection of mucosal human papillomavirus types 6/11 in cutaneous lesions from transplant recipients. J Invest Dermatol 1993; 101: 286–291.

    Article  PubMed  CAS  Google Scholar 

  62. Berkhout RJM, Tieben LM, Smits HL et al. Detection and typing of epidermodysplasia verruciformis-associated human papillomavirus types in cutaneous cancers from renal transplant recipients: a nested approach. J Clin Microbiol 1965; 33: 690–695.

    Google Scholar 

  63. Grimmel M, de Villiers EM, Pawlita M et al. Characterization of a new human papillomavirus type (HPV 41) isolated from dissiminated warts and the detection of closely related sequences in some squamous cell carcinomas. Int J Cancer 1988; 41: 5–9.

    Article  PubMed  CAS  Google Scholar 

  64. Kawashima M, Favre M, Obalek S et al. Premalignant lesions and cancers of the skin in the general population: evaluation of the role of human papillomaviruses. J Invest Dermatol 1990; 95: 537–42.

    Article  PubMed  CAS  Google Scholar 

  65. Moy RL, Eliezri YD, Nuovo GJ. HPV DNA in periungual SSC. J Am Med Assoc 1989; 261: 2669–2673.

    Article  CAS  Google Scholar 

  66. Eliezri YD, Silverstein SJ, Nuovo GJ. Occurrence of human papillomavirus type 16 DNA in cutaneous squamous and basal cell neoplasms. J Am Acad Dermatol 1990; 23: 836–842.

    Article  PubMed  CAS  Google Scholar 

  67. Rigoni-Stern D. Fatti statistici relativialle malatia cancerose. G Sery Prog Pathol Therap 1842; 2: 507–517.

    Google Scholar 

  68. Rotkin ID. A comparison review of key epidemiological studies in cervical cancer related to current searches for transmissible agents. Cancer Res 1973; 33: 1353–1367.

    PubMed  CAS  Google Scholar 

  69. zur Hausen H. Condylomata acuminata and human genital cancer. Cancer Res 1976; 36: 530.

    Google Scholar 

  70. zur Hausen H. Human papillomaviruses and their possible role in squamous cell carcinomas. Current Topics Microbiol Immunol 1977; 78: 1–30.

    Article  Google Scholar 

  71. Meisels A, Fortin R. Condylomatous lesions of the cervix and vagina. I. Cytological patterns. Act Cytologica 1976; 20: 505–509.

    CAS  Google Scholar 

  72. Meisels A, Roy M, Fortier M et al. Human papillomavirus infection of the cervix: the atypical condyloma. Act Cytologica 1981; 25: 7–16.

    CAS  Google Scholar 

  73. Gissmann L, zur Hausen H. Partial characterization of viral DNA from human genital warts (condylomata acuminata). Int J Cancer 1980; 25: 605–609.

    Article  PubMed  CAS  Google Scholar 

  74. de Villiers EM, Gissmann L, zur Hausen H. Molecular cloning of viral DNA from human genital warts. J Virol 1981; 40: 932–935.

    PubMed  Google Scholar 

  75. Gissmann L, Diehl V, Schultz-Coulon H et al. Molecular cloning and characterization of human papillomavirus DNA from a laryngeal papilloma. J Virol 1982; 44: 393–400.

    PubMed  CAS  Google Scholar 

  76. Durst, M., Gissmann, L., Ikenberg, H., and zur Hausen, H. 1983. A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc Nat Acad Sci USA 80, 3812–3815.

    Article  PubMed  CAS  Google Scholar 

  77. Boshart M, Gissmann L, Ikenberg H et al. A new type of papillomavirus DNA, its presence in genital cancer and in cell liness derived from genital cancer. EMBO J 1984; 3: 1151–1157.

    PubMed  CAS  Google Scholar 

  78. Ikenberg H, Gissmann L, Gross G et al. Human papillomavirus type 16 related DNA in genital Bowen’s disease and in Bowenoid papulosis. Int J Cancer 1983; 32: 563–564.

    Article  PubMed  CAS  Google Scholar 

  79. Schwarz E, Freese K, Gissmann L et al. Structure and transcription of human papillomvirus sequences in cervical carcinoma cells. Nature 1985; 314: 111–114.

    Article  PubMed  CAS  Google Scholar 

  80. zur Hausen H. Cell-virus gene balance hypothesis of carcinogenesis. Behring Inst Mitt 1977; 61: 23–30.

    Google Scholar 

  81. zur Hausen H. The role of viruses in human tumors. In: Klein G, Weinhouse S, eds. Advances in Cancer Res 1980; 33: 77–107.

    Google Scholar 

  82. zur Hausen H. Intracellular surveillance of persisting viral infections: Human genital cancer resulting from failing cellular control of papillomavirus gene expression. Lancet 1986; 2: 489–491.

    Article  PubMed  Google Scholar 

  83. zur Hausen H. Genital papillomavirus infections. In: Rigby PWJ, Wilkie NM, eds. Viruses and Cancer. Cambridge: Cambridge University Press 1986; 83–90.

    Google Scholar 

  84. zur Hausen H. Papillomaviruses in anogenital cancer: A model to understand the role of viruses in human cancers. Cancer Res 1989; 49: 4677–4681.

    PubMed  Google Scholar 

  85. Yasumoto S, Burckhardt AL, Doninger J et al. Human papillomavirus type 16 DNA induced malignant transformation of NIH3T3 cells. J Virol 1986; 57: 572–577.

    PubMed  CAS  Google Scholar 

  86. Durst M, Dzarlieva-Petrusevska RT, Boukamp P et al. Molecular and cytogenetic analysis of immortalized human primary keratinocytes obtained after transfection with human papillomavirus type 16 DNA. Oncogene 1987; 1: 251–256.

    PubMed  CAS  Google Scholar 

  87. Pirisi L, Yasumoto S, Fellery M et al. Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA. J Virol 1987; 61: 1061–1066.

    PubMed  CAS  Google Scholar 

  88. Manger K, Phelps WC, Bubb V et al. The E6 and E7 genes of human papillomavirus type 16 are necessary and sufficient for transformation of primary human keratinocytes. J Virol 1989; 63: 4417–4423.

    Google Scholar 

  89. Halbert CL, Demers GW, Galloway DA. The E7 gene of human papillomavirus type 16 is sufficient for immortalization of human epithelial cells. J Virol 1991; 65: 473–478.

    PubMed  CAS  Google Scholar 

  90. Band V, De Caprio JA, Delmolina L et al. Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. J Virol 1991; 65: 6671–6676.

    PubMed  CAS  Google Scholar 

  91. von Knebel Doeberitz M, Oltersdorf T, Schwarz E et al. Correlation of modified human papillomavirus early gene expression with altered growth properties in C4–1 cervical carcinoma cells. Cancer Res 1988; 48: 3780–3786.

    Google Scholar 

  92. von Knebel Doeberitz M, Rittmüller C, zur Hausen H et al. Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV E6–E7 antisense RNA. Int J Cancer 1992; 51: 831–834.

    Article  Google Scholar 

  93. von Knebel Doeberitz M, Rittmüller C, Aengeneyndt F et al. Reversible repression of papillomavirus oncogene expression in cervical carcinoma cells: consequences for the phenotype and E6-p53 and E7pRB interactions. J Virol 1994; 68: 2811–2821.

    Google Scholar 

  94. Pereira-Smith OM, Smith JR. Expression of SV40 antigen in finite lifespan hybrids of normal and SV40-transformed fibroblasts. Somatic Cell Genetics 1981; 7: 411–421.

    Article  PubMed  CAS  Google Scholar 

  95. Chen TM, Pecoraro G, Defendi V. Genetic analysis of in vitro progression of human papillomavirus-transfected human cervical cells. Cancer Res 1993; 53: 1167–1171.

    PubMed  CAS  Google Scholar 

  96. zur Hausen H. Disrupted dichotomous intracellular control of human papillomavirus infection in cancer of the cervix. Lancet 1994; 343: 955–957.

    Article  PubMed  Google Scholar 

  97. Rösl F, Durst M, zur Hausen H. Selective suppression of human papillomavirus transcription in nontumorigenic cells by 5-azacytidine. EMBO J 1988; 7: 1321–1328.

    PubMed  Google Scholar 

  98. Rösl F, Achtstetter T, Hutter KJ et al. Extinction of the HPV 18 upstream regulatory region in cervical carcinoma cells after fusion with nontumorigenic human keratinocytes under nonselective conditions. EMBO J 1991; 10: 1337–1345.

    PubMed  Google Scholar 

  99. Rösl F, Lengert M, Albrecht J et al. Differential regulation of the JE gene encoding the monocyte chemoattractant protein (MCP-1) in cervical carcinoma cells and derived hybrids. J Virol 1994; 68: 2142–2150.

    PubMed  Google Scholar 

  100. Bartsch D, Boye B, Baust C et al. Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor ß gene in nontumorigenic and tumorigenic HeLa hybrid cells. EMBO J 1992; 11: 2283–2291.

    PubMed  CAS  Google Scholar 

  101. Durst M, Glitz D, Schneider A et al. Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: analysis by in situ hybridization. Virology 1992; 189: 132–140.

    Article  PubMed  CAS  Google Scholar 

  102. Smits PHM, Smits HL, Minnaar R et al. The trans-activation of the HPV 16 long control region in human cells with a deletion in the short arm of chromosome 11 is mediated by the 55kDa regulatory subunit of protein phosphatase 2A. EMBO J 1992; 11: 4601–4606.

    PubMed  CAS  Google Scholar 

  103. York IA, Roop C, Andrews DW et al. A cytosolic Herpes simplex virus protein inhibits antigen presentation to CD8+ T lymphocytes. Cell 1994; 77: 525–535.

    Article  PubMed  CAS  Google Scholar 

  104. Ge R, Liu X, Ricciardi RP. E1A oncogene of adenovirus-12 mediates trans-repression of MHC class I transcription in Ad5/Ad12 somatic hybrid transformed cells. Virology 1994; 203: 389–392.

    Article  PubMed  CAS  Google Scholar 

  105. Dyson N, Howley PM, Munger K et al. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 1989; 243: 934–937.

    Article  PubMed  CAS  Google Scholar 

  106. Chellappan S, Kraus V, Kroger B et al. Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between transcription factor E2F and the retinoblastoma gene product. Proc Nat Acad Sci USA 1992; 89: 4549–4553.

    Article  PubMed  CAS  Google Scholar 

  107. Werness BA, Levine AJ, Howley PM. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 1990; 248: 76–79.

    Article  PubMed  CAS  Google Scholar 

  108. Lane DP, Crawford LV. T antigen is bound to a host protein in SV 40-transformed cells. Nature 1979; 278: 261–263.

    Article  PubMed  CAS  Google Scholar 

  109. Linzer DIH, Levine AJ. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells. Cell 1979; 17: 43–52.

    Article  PubMed  CAS  Google Scholar 

  110. DeCaprio JA, Ludlow JW, Figge J et al. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene. Cell 1988; 54: 275–283.

    Article  Google Scholar 

  111. Scheffner M, Werness BA, Huibregtse JM et al. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 1990; 63: 1129–1136.

    Article  PubMed  CAS  Google Scholar 

  112. White AE, Livanos EM, Tlsty TD. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes and Development 1994; 8: 666–677.

    Article  PubMed  CAS  Google Scholar 

  113. zur Hausen H. Viruses in human cancer. Science 1991; 254: 1167–1173.

    Article  PubMed  Google Scholar 

  114. Hurlin PJ, Kaur P, Smith P et al. Progression of human papillomavirus type 18 immortalized human keratinocytes to a malignant phenotype. Proc Natl Acad Sci USA 1981; 88: 570–574.

    Article  Google Scholar 

  115. Pecoraro G, Lee M, Morgan D et al. Evolution of in vitro transformation and tumorigenesis of HPV 16 and HPV 18 immortalized primary cervical epithelial cells. Am J Pathol 1991; 138: 1–8.

    PubMed  CAS  Google Scholar 

  116. Pagano M, Durst M, Joswig S et al. Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene 1992; 7: 1681–1686.

    PubMed  CAS  Google Scholar 

  117. Zerfass K, Schulze A, Spitkovsky D et al. S phase induction by the human papillomavirus 16 E7 oncogene reveals an activation cascade of cyclin E and cyclin A transcription. J Virol 1995; 69: 6389–6399.

    CAS  Google Scholar 

  118. Kirnbauer R, Booy F, Cheng N et al. Papillomavirus L1 major capsid protein self-assembles into virus-like particles that are highly immunogenic. Proc Natl Acad Sci USA 1992; 89: 12180–12184.

    Article  PubMed  CAS  Google Scholar 

  119. Kirnbauer R, Hubbert NL, Wheeler CM et al. A virus-like particle enzyme-linked immunosorbent assay detecs serum antibodies in a majority of women infected with human papillomavirus type 16. J Nat Cancer Inst 1994; 86: 494–9.

    Article  PubMed  CAS  Google Scholar 

  120. IARC Monograph on Evaluation of Carcinogenic Risks of Humans. Vol. 59. Hepatitis Viruses, IARC Lyon, 1994.

    Google Scholar 

  121. IARC Monograph on Evaluation of Carcinogenic Risks of Humans. Vol. 61. Schistosomes, Liver Flukes and Helicobacter pylori. IARC Lyon, 1994.

    Google Scholar 

  122. Munoz N, Bosch FX, de Sanjose S et al. The causal link between human papillomavirus and invasive cervical cancer: a population-based case-control study in columbia and Spain. Int J Cancer 1992; 52: 743–749.

    Article  PubMed  CAS  Google Scholar 

  123. Schiffman MH, Bauer HM, Hoover RN et al. Epidemiological evidence showing that human papillomavirus infection causes most cervical intraepithelial neoplasia. J Natl Cancer Inst 1993; 85: 958–964.

    Article  PubMed  CAS  Google Scholar 

  124. Bosch FX, Manos MM, Munoz N et al. Int Biol Study Cervical Cancer (IBSSC) Study Group. Prevalence of human papillomavirus in cervical cancer: a worldwide perspective. J Natl Cancer Inst 1995; 87: 796–802.

    CAS  Google Scholar 

  125. Matsukura T, Sugase M. Identification of genital human papillomaviruses in cervical biopsy specimen: segregation of specific virus types in specific clinicopathologic lesions. Int J Cancer 1995; 61: 13–22.

    Article  PubMed  CAS  Google Scholar 

  126. Syrjänen K. Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas. Arch Geschwulstforsch 1982; 52: 283–292.

    PubMed  Google Scholar 

  127. de Villiers EM, Weidauer H, Otto H et al. Papillomavirus DNA in human tongue carcinomas. Int J Cancer 1985; 36: 575–578.

    Article  PubMed  Google Scholar 

  128. Löning T, Ikenberg H, Becker J et al. Analysis of oral papillomas, leukoplakias and invasive carcinomas for human papiloomavirus type related DNA. J Invest Dermatol 1985; 84: 417–420.

    Article  PubMed  Google Scholar 

  129. Stremlau A, Gissmann L, Ikenberg H et al. Human papilloma virus type 16 related DNA in an anaplastic carcinoma of the lung. Cancer 1995; 55: 1737–1740.

    Article  Google Scholar 

  130. Kahn T, Schwarz E, zur Hausen H. Molecular cloning and characterization of the DNA of a new human papillomavirus (HPV 30) from a laryngeal carcinoma. Int J Cancer 1986; 37: 61–65.

    Article  PubMed  CAS  Google Scholar 

  131. Scheurlen W, Stremlau A, Gissmann L. Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma. Int J Cancer 1986; 38: 671–676.

    Article  PubMed  CAS  Google Scholar 

  132. Shamanin V, zur Hausen H, Lavergne D et al. HPV infections in nonmelanoma skin cancers from renal transplant recipients and nonimmunosuppressed patients. J Nat Cancer Inst 1996; 88: 802–811.

    Article  PubMed  CAS  Google Scholar 

  133. De Villiers E M. 1989. Heterogeneity of human papillomavirus group. J Virol 63: 4898–4903.

    PubMed  Google Scholar 

  134. De Villiers EM. Papillomavirus and HPV typing. Clinics in Dermatology 1997; (in press).

    Google Scholar 

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zur Hausen, H. (1997). Human Papillomaviruses and Cancer: A Retrospective. In: Papillomaviruses in Human Cancer. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6127-6_1

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  • DOI: https://doi.org/10.1007/978-1-4757-6127-6_1

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