The Effect of Graded Systemic Hypoxaemia on Hepatic Tissue Oxygenation

  • Wenxuan Yang
  • Tariq Hafez
  • Cecil S. Thompson
  • Dimitri P. Mikhailidis
  • Brain R. Davidson
  • Marc C. Winslet
  • Alexander M. Seifalian
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)


Hepatic hypoxia occurs during liver surgery and transplantation.1 Liver tissue oxygenation has been shown to provide valuable information on early graft function and survival in experimental animal models2 and human liver transplantation.3 Tissue hypoxia has been recognized as a specific stimulus for gene expression.4 Although the liver is generally regarded as being resistant to a reduction in oxygen supply, hypoxia can induce profound metabolic changes which may have a detrimental effect on hepatocellular function.5,6 Cellular respiratory rate is normally determined by metabolic activity, but it also depends on oxygen availability if the cell O2 tension (pO2) falls bellow a critical value.7 During acute hypoxia, cellular respiration is independent of the O2 concentration as long as the pO2 remains above a critical value.


Tissue Oxygenation Hepatic Tissue Systemic Hypoxia Portal Venous Blood Flow Early Graft Function 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Wenxuan Yang
  • Tariq Hafez
  • Cecil S. Thompson
  • Dimitri P. Mikhailidis
  • Brain R. Davidson
  • Marc C. Winslet
  • Alexander M. Seifalian
    • 1
  1. 1.University Department of Surgery and Liver Transplantation UnitRoyal Free and University College Medical School, University College London, Royal Free HospitalLondonUK

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