Partitioning of Arterial and Venous Volumes in the Brain under Hypoxic Conditions

  • Christopher B. Wolff
  • Christopher H. E. Imray
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)

Abstract

Cerebral oxygen delivery is sustained in the face of, at least moderate, hypoxia.1 The measurements required to show this have, in the past, been especially invasive, with a requirement for jugular venous bulb sampling and carotid arterial administration of a marker to allow measurement of flow by dye dilution.2 With the advent of middle cerebral arterial blood velocity measurement (Doppler) and arterial oxygen saturation measurement (pulse oximetry) the procedure is greatly simplified, at least on a relative basis: SaO2 multiplied by middle cerebral artery velocity will, arguably, give individual changes in oxygen delivery for, at least, the distribution supplied by the middle cerebral artery. This will, for normal subjects, usually change in proportion to global changes.

Keywords

Oxygen Delivery Cerebral Blood Volume Near Infrared Spectroscopy NIRS Data Blood Volume Fraction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    C.B. Wolff, P. Barry and D.J. Collier Cardiovascular and respiratory adjustments at altitude sustain cerebral oxygen delivery — Severinghaus revisited. Comparative Biochemistry and Physiology Part A 132, 221229 (2002).Google Scholar
  2. 2.
    Severinghaus, J.W., Chiodi, H., Eger, E.I., Brandstater, B. and Hornbein, T.F. Cerebral blood flow in man at high altitude. Circulation Research 19 274-282. (1966.)Google Scholar
  3. 3.
    P.W. McCormick, M. Stewart, M.G. Goetting and G. Balakrishnan, Regional cerebrovascular oxygen saturation measured by optical spectroscopy in humans. Stroke 22, 596 - 602 (1991)PubMedCrossRefGoogle Scholar
  4. 4.
    C.H.E. Imray, A.W. Wright, C. Chan, A.R. Bradwell and the Birmingham Medical Research and Expeditionary Society (BMRES). Carbon dioxide increases cerebral oxygen delivery when breathing hypoxic gas mixtures. High Altitude Medicine & Biology 3 (1), p106 A30, 2002 (abstract).Google Scholar
  5. 5.
    C.H.E. Imray, S. Walsh, T. Clarke, H. Hoar, T.C. Harvey, C.W.M. Chan, P.J.G. Forster and the BMRES. 3% Carbon dioxide increases cerebral oxygen delivery at 150m & 3549m. High Altitude Medicine & Biology 3 (1), p106 A31, 2002 (abstract).Google Scholar
  6. 6.
    C.H.E. Imray, H. Hoar, A.D. Wright, A.R. Bradwell C. Chan, and the BMRES. Cerebral oxygen delivery falls with voluntary forced hyperventilation at altitude. High Altitude Medicine & Biology 3 (1), p106 A32, 2002 (abstract).Google Scholar
  7. 7.
    Elwell, C.E., Cope, M., Edwards, A.D., Wyatt, J.S., Delpy, D.T., Reynolds, E.O.R.. Quantification of adult cerebral haemodynamics by near infrared spectroscopy. J. Appl. Physiol. 77, 2753-2760 (1994).Google Scholar
  8. 8.
    T.Q. Duong and S-G. Kim, In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain. Magnetic Resonance in Medicine 43, 393 - 402 (2000).Google Scholar
  9. 9.
    H.Ito, I.Kanno, H, lids, J. Hatazwa, E. Shimosegawa, H. Tamura and T. Okudera, Arterial fraction of cerebral blood volume in humans measured by positron emission tomography. Annals of Nuclear Medicine 15 (2), 111 - 116 (2001).Google Scholar

Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Christopher B. Wolff
    • 1
  • Christopher H. E. Imray
    • 2
  1. 1.Applied PhysiologySherrington SchoolLondonUK
  2. 2.Imray The Immunodiagnostic Research Laboratory, The Medical SchoolUniversity of BirminghamEdgbaston, BirminghamUK

Personalised recommendations