Influence of Neuronally Derived Nitric Oxide on Blood Oxygenation and Cerebral pO2 in a Mouse Model Measured by EPR Spectrometry

  • Matthew P. Thomas
  • Simon K. Jackson
  • Philip E. James
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)


Nitric oxide (NO·) is widely accepted as a key component in the maintenance of resting cerebral blood flow (CBF). The complex interaction between NO· and other regulatory mediators such as neural activity, pH and arterial pCO2 determines the tone of cerebral blood vessels and thus oxygen delivery through blood flow 1−3.


Nitric Oxide Cerebral Blood Flow Cerebral Blood Flow Response Neuron Ally Oximetry Measurement 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Matthew P. Thomas
    • 1
  • Simon K. Jackson
    • 2
  • Philip E. James
    • 3
  1. 1.Department of Cardiology, Wales Heart Research InstituteUniversity of Wales College of MedicineHeath Park. CardiffUK
  2. 2.Department of Medical MicrobiologyHeath Park. CardiffUK
  3. 3.Department of CardiologyHeath Park. CardiffUK

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