Abstract
Protein C (PC) is one of the most important proteins involved in the blood hemostasis. It is a potent anticoagulant, antithrombotic, and anti-inflammatory agent. Individuals with heterozygous PC deficiency have, by the age of 40, an 8–10 times higher risk of the thrombotic complications1. Accordingly, PC deficiency may lead to problems of oxygen and nutrient transport to tissue. Therefore, early diagnosis of PC deficiency is crucial to prevent thrombo-embolic episodes, such as, lung embolism, stroke, and/or heart attack.
Keywords
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Markis, M., Rosendaal, F. R., and Preston, F. E., Familial thrombophiloa: genetic risk factors and management, J. Internal Medicine 242 (Suppl. 740), 9–15 (1997).
Colman, R. W., Hirsh, J., Marder, V. J., and Salzman, E. W., Hemostasis and Thrombosis: basic principles and clinical practive, 3rd ed. ( J.B. Lippincott Company, Philadelphia, 1993 ), p. 262.
Spiker, J. O., Kang, K. A., Drohan. W. N., and Bruley, D. F., Protein C detection via fluorophore mediated immuno-optical biosensor, Adv. Exp. Med. Biol. 428, 621–627 (1997).
Spiker, J. O., Preliminary study of a fiber-optic based protein C biosensor utilizing fluorophore mediated immunological methods, MS Thesis, Chemical Engineering, University of Maryland Baltimore County, Maryland, (1999a).
Kwon, H. J., Theoretical and experimental investigation on sensing performance of Protein C immunooptical sensor for physiological samples, PhD dissertation, Chemical Engineering, University of Louisville, Louisville, KY, (2002)
Spiker, J. O. and Kang, K. A., Preliminary study of real-time fiber optic based protein C biosensor, Biotech. Bioeng. 66 (3), 158–163, (1999b).
Spiker, J. O., Kang, K.A., Drohan. W. N., and Bruley, D. F., Preliminary study of biosensor optimization for the detection of protein C, Adv. Exp. Med. Bio!. 454, 681–688, (1998).
Balcer, H. I., Spiker, J. O., and Kang, K. A., Sensitivity of a protein C immuno-sensor with and without human serum albumin, Adv. Exp. Med. Bio. 471, 605–612, (1999).
Balcer, H. I., Studies of Protein C Biosensor Performance for Physiological Samples, MSThesis, Biological Science, University of Maryland Baltimore County, Maryland (2000).
Balcer, H. I., Kwon, H. J., and Kang, K. A., Assay procedure optimization of rapid, reusable protein immunosensor for physiological samples, Ann. Biomed. Eng. 30 (10), 141–147, (2002).
Spiker, J. O., Drohan, W. N., and Kang, K. A., Reusability study of fiber optic based protein C biosensor, Adv. Exp. Med. Bio!. 471, 731–739, (1999a).
Kwon, H. J., Balcer, H. I., and Kang, K. A., Sensing performance of protein C immuno-biosensor for biological samples and sensor minimization, Comparative Biochem. Phys., part A 132, 231–238, (2002).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2003 Springer Science+Business Media New York
About this paper
Cite this paper
Tang, L., Kang, K.A. (2003). Sensing Improvement of Protein C Biosensor by Sample Circulation. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_25
Download citation
DOI: https://doi.org/10.1007/978-1-4757-6125-2_25
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4419-3428-4
Online ISBN: 978-1-4757-6125-2
eBook Packages: Springer Book Archive