Novel Injectable Gels for the Sustained Release of Protein C

  • Mahesh V. Chaubal
  • Zhong Zhao
  • Duane F. Bruley
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)


Protein C is a vitamin K dependent protein present in the human blood plasma at a concentration of 4 µg/ml. The protein exists as a zymogen precursor of a serine protease and is an important component of the coagulation cascade. The activated form of protein C regulates the coagulation cascade preventing abnormal blood clots, thus maintaining a regular flow of blood and oxygen to tissues. Protein C deficiency, which affects up to 1 in 300 people in the general population (Nizzi and Kaplan, 1999), causes a lack of regulation of the natural blood coagulation pathway and could lead to massive thrombosis (clogging of blood vessels due to clots). Such clogging of blood vessels can further cause tissue oxygen deprivation resulting in tissue damage. Serious examples of this damage include stroke, heart attack, pulmonary embolism, tissue necrosis and other complications that can result in amputation or death.


Sustained Release Initial Burst Ethyl Lactate Benzyl Benzoate Phase Transition Process 
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Copyright information

© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Mahesh V. Chaubal
    • 1
  • Zhong Zhao
    • 2
  • Duane F. Bruley
    • 1
  1. 1.University of Maryland Baltimore CountyBaltimoreUSA
  2. 2.Guilford PharmaceuticalsBaltimoreUSA

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