Abstract
Protein C is a vitamin K dependent protein present in the human blood plasma at a concentration of 4 µg/ml. The protein exists as a zymogen precursor of a serine protease and is an important component of the coagulation cascade. The activated form of protein C regulates the coagulation cascade preventing abnormal blood clots, thus maintaining a regular flow of blood and oxygen to tissues. Protein C deficiency, which affects up to 1 in 300 people in the general population (Nizzi and Kaplan, 1999), causes a lack of regulation of the natural blood coagulation pathway and could lead to massive thrombosis (clogging of blood vessels due to clots). Such clogging of blood vessels can further cause tissue oxygen deprivation resulting in tissue damage. Serious examples of this damage include stroke, heart attack, pulmonary embolism, tissue necrosis and other complications that can result in amputation or death.
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Chaubal, M.V., Zhao, Z., Bruley, D.F. (2003). Novel Injectable Gels for the Sustained Release of Protein C. In: Thorniley, M., Harrison, D.K., James, P.E. (eds) Oxygen Transport to Tissue XXV. Advances in Experimental Medicine and Biology, vol 540. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6125-2_21
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DOI: https://doi.org/10.1007/978-1-4757-6125-2_21
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