Estimation of Cerebral Blood Flow in a Newborn Piglet Model of Neonatal Asphyxia
Hypoxic ischemic encephalopathy (HIE) in newborn infants is one of the causes of later serious brain damage. In recent years, hypothermia therapy has attracted attention as an effective means of for preventing HIE-induced brain damage and has been used clinically 1, 2,3. However, the problem of which newborn infants should be selected for hypothermia therapy remains unsolved. Currently, selection is based on results of various tests such as neurological tests, blood biochemical tests and electroencephalography (EEG) 4. However, there is no definitive evaluation method.
KeywordsCerebral Blood Flow Newborn Infant Indocyanine Green Hypoxic Ischemic Encephalopathy Newborn Piglet
Unable to display preview. Download preview PDF.
- 7.J. Peter, K. Marks, I. Roberts, D. Azzopardi, AD. Edwards, Measurement of cerebral blood flow in newborn infants using near infrared spectroscopy with Indocyanine green, Pediatr, Res. 43, 34–39 (1998).Google Scholar
- 8.T. Kusaka, K. Isobe, K. Nagano, K. Okubo, S. Yasuda, K. Kawada, S. Itoh, S. Onishi, I. Oda, Y. Wada, I. Konishi, T. Tsunazawa, Estimation of regional cerebral blood flow distribution in infants by multichannel near-infrared spectroscopy with indocyanine green, Proc. SPIE 4250, 301–305 (2001).CrossRefGoogle Scholar