Oxygen and Oxidative Stress Modulate the Expression of Uncoupling Protein-5 in Vitro and in Vivo

  • Paola Pichiule
  • Juan C. Chavez
  • Joseph C. LaManna
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 540)


Uncoupling protein 5 (UCP5), also referred to as brain mitochondrial carrier protein (BMCP 1), belongs to the family of mitochondrial membrane transporters known as uncoupling proteins (UCPs)1. Five UCPs have been cloned, named UCP1, UCP2, UCP3, UCP4 and UCP5/BMCP12. It is well established that UCP1, the prototypical UCP expressed only in brown adipocytes, dissipates the mitsochondrial proton gradient across the inner membrane and hence potential energy is lost as heat2. However, it is not known whether UCP 2–5 are true uncoupling proteins and have thermogenic properties or have other in vivo physiological functions. It has been proposed that the novel UCPs might play a role in the regulation of reactive oxygen species (ROS) production3,4


Uncouple Protein Hypobaric Hypoxia Brown Adipocyte Transient Cerebral Ischemia UCP3 Gene 
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© Springer Science+Business Media New York 2003

Authors and Affiliations

  • Paola Pichiule
    • 1
  • Juan C. Chavez
    • 1
  • Joseph C. LaManna
    • 1
  1. 1.Department of AnatomyCase Western Reserve UniversityClevelandUSA

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