Skip to main content

Abstract

Photon movement in a turbid medium such as biological tissue has posed challenging problems due to the strong influence of light scattering at ultraviolet, visible, and near-infrared wavelengths. Photons which escape from a tissue as either reflectance or transmittance may have propagated along many different paths within the tissue. Therefore, it is difficult to interpret the magnitude of photon escape in terms of either tissue absorption or the presence of an internal heterogeneity. The use of measurement techniques which allow time-resolved measurements of photons has offered a new approach toward understanding photon propagation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 74.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Jacques SL. “Time resolved propagation of ultrashort laser pulses in turbid tissues,” Appl. Opt. 28: 2223–2229 (1989).

    Article  ADS  Google Scholar 

  2. Cashwell ED, Everett CJ. A Practical Manual on the Monte Carlo Method for Random Walk Problems, Pergamon Press, New York (1959).

    Google Scholar 

  3. Wang L-H, Jacques SL. Monte Carlo Modeling of Light Transport in Multi-layered Tissues in Standard C, University of Texas / M. D. Anderson Cancer Center (1992). The software is available on our anonymous ftp site at laser.mda.uth.tmc.edu (129.106.60.92), or through e-mail to mcmllaser.mda.uth.tmc.edu, or by writing to us at Laser Lab-17, UTMD Anderson Cancer Center, 1515 Holcombe Blvd., Houston, TX 77030.

    Google Scholar 

  4. Weinmann JA, Shipley ST. “Effects of multiple scattering on laser pulses transmitted through cloud,” J. Geophys. Res., 77: 7123–7128 (1972).

    Article  ADS  Google Scholar 

  5. Bucher EA, Lerner RM. “Experiments on light pulse communication and propagation through atmospheric clouds,” Appl. Opt. 12: 2401–2414 (1973).

    Article  ADS  Google Scholar 

  6. Ishimaru A. “Diffusion of a pulse in densely distributed scatterers,” J. Opt. Soc. Am. 68: 1045–1050 (1978).

    Article  ADS  Google Scholar 

  7. Shimizu K, Ishimaru A, Reynolds L, Breuckner AP. “Backscattering of a picosecond pulse from densely distributed scatterers,” Appl. Opt. 18: 3484–3488 (1979).

    Article  ADS  Google Scholar 

  8. Kuga Y, Ishimaru A, Bruchner AP. “Experiments on picosecond pulse propagation in a diffuse medium,” J. Opt. Soc. Am. 73: 1812–1815 (1983).

    Article  ADS  Google Scholar 

  9. Ito S, Furutsu K. “Theory of light pulse propagation through thick clouds,” J. Opt. Soc. Am. 70: 366–374 (1980).

    Article  MathSciNet  ADS  Google Scholar 

  10. Patterson MS, Chance B, Wilson BC. “Time resolved reflectance and transmittance for the noninvasive measurement of tissue optical properties,” Appl. Opt. 28: 2331–2336 (1989).

    Article  ADS  Google Scholar 

  11. Madsen SJ, Wilson BC, Patterson MS, Park YD, Jacques SL, Hefetz Y. “Experimental tests of a simple diffusion model for the estimation of scattering and absorption coeffiicients of turbid media from time-resolved diffuse reflectance measurements,” Appl. Opt. 31: 3509–3517 (1992).

    Article  ADS  Google Scholar 

  12. Bonner RF, Nossal R, Weiss GH. “A random walk theory of time-resolved optical absorption spectroscopy in tissue,” in Chance B (ed.), Proc. Workshop Photon Migration in Tissues, Plenum Press, New York (1989).

    Google Scholar 

  13. Nossal R, Bonner RF, Weiss GH. “The influence of pathlength on remote optical sensing of properties of biological tissues,” Appt. Opt. 28: 2238–2244 (1989).

    Article  ADS  Google Scholar 

  14. Duderstadt JJ, Hamilton LJ. Nuclear Reactor Analysis, Wiley, New York (1976).

    Google Scholar 

  15. Jacques SL, Hielscher AH, Wang LH. “Effects of sources, boundaries, and heterogeneities on photon migration,” in Alfano RR (ed.), Proceedings on Advances in Optical Imaging and Photon Migration, Optical Society of America Vol. 21, pp. 83–87 (1994).

    Google Scholar 

  16. Tromberg BJ, Svaasand LO, Tsay TT, Haskell RC. “Properties of photon density waves in multiple-scattering media,” Appl. Opt. 32: 607–616 (1993).

    Article  ADS  Google Scholar 

  17. Piston DW, Marriott G, Radivoyevich T, Clegg RM, Jovin TM, Gratton E. “Wide-band acousto-optic light modulator for frequency domain fluorometry and phosphorimetry,” Rev. Sci. Instrum. 60: 2596–2600 (1989).

    Article  ADS  Google Scholar 

  18. Peterman K. Laser Diode Modulation and Noise, KTK Scientifiic Publishers, Dodrecht (1988).

    Book  Google Scholar 

  19. Lakowicz JR, Laczko G, Gryczynski I. “2-GHz frequency-domain fluorometer,” Rev. Sci. In-strum. 57: 2499–2506 (1986).

    Article  ADS  Google Scholar 

  20. Press WH, Flannery BP, Teukolsky SA, Vetterling WT. Numerical Recipes in C, 2nd ed., New York, Cambridge University Press (1992).

    MATH  Google Scholar 

  21. Jacques SL. “Time-resolved reflectance spectroscopy in turbid tissues,” IEEE Trans. Biomed. Eng. 36: 1155–1161 (1989).

    Article  Google Scholar 

  22. Jacques SL, Flock ST. “Effect of surface boundary on time-resolved reflectance: measurements with a prototype endoscopic catheter,” in Chance B(ed.), Proceedings of Time-Resolved Spec-troscopy and Imaging of Tissues, SPIE Vol. 1431, pp. 12–20 (1991).

    Google Scholar 

  23. Wray S, Cope M, Delpy DT, Wyatt JS, Reynolds EOR. “Characterization of the near infrared absorption spectra of cytochrome aa3 and haemoglobin for the non-invasive monitoring of cerebral oxygenation,” Biochim. Biophys. Acta 933: 184–192 (1988).

    Article  Google Scholar 

  24. Sevick EM, Chance B, Leigh J, Nioka S, Maris M. “Quantitation of time- and frequency-resolved optical spectra for the determination of tissue oxygenation,” Anal. Biochem. 195: 330— 351 (1991).

    Google Scholar 

  25. Hielscher AH, Liu H, Wang LH, Tittel FK, Chance B, Jacques SL. “Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy (I): Influence of the skin, skull and meniges,” in Chance B, Alfano RR (eds.), Biochemical Diagnostic Instrumentation A: Optical Diagnosis of Blood and Blood Components, Proc. SPIE Vol. 2136, pp. 4–15 (1994).

    Google Scholar 

  26. Liu H, Hielscher AH, Beauvoit B, Wang LH, Jacques SL, Tittel FK, Chance B. “Determination of blood oxygenation in the brain by time-resolved reflectance spectroscopy (II): Contribution of vascular absorption and tissue background absorption,” in Chance B, Alfano RR (eds.), Biochemical Diagnostic Instrumentation A: Optical Diagnosis of Blood and Blood Compo-nents, Proc. SPIE Vol. 2136, pp. 16–25 (1994).

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1995 Springer Science+Business Media New York

About this chapter

Cite this chapter

Jacques, S.L., Wang, L., Hielscher, A.H. (1995). Time-Resolved Photon Propagation in Tissues. In: Welch, A.J., Van Gemert, M.J.C. (eds) Optical-Thermal Response of Laser-Irradiated Tissue. Lasers, Photonics, and Electro-Optics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6092-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6092-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6094-1

  • Online ISBN: 978-1-4757-6092-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics