Skip to main content

Patterns of Oligodendrocyte Function Seen by Immunocytochemistry

  • Chapter
Oligodendroglia

Part of the book series: Advances in Neurochemistry ((ANCH,volume 5))

Abstract

The classification of cells into types and the functions assigned to each cell type have, in the past, been dependent primarily upon morphological criteria. The functions usually associated with oligodendrocytes are: (1) myelin formation by interfascicular oligodendrocytes and (2) nutrition of neurons by satellite oligodendrocytes in the gray matter, the satellite cells being presumed not to participate in myelination (for a review, see Raine, 1981). More recently, immuncytochemistry has become a useful tool for confirming and extending (or contradicting) conclusions based on morphological observations. In addition, immunocytochemical studies have led to the discovery of new functions associated with oligodendrocytes and have shown that oligodendrocytes can no longer be considered as being solely myelin-producing cells.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abramsky, O., Lisak, R. P., Silberberg, D. H., and Pleasure, D. E., 1977, Antibodies to oligodendroglia in patients with multiple sclerosis, N. Engl. J. Med. 297: 1207–1211.

    PubMed  CAS  Google Scholar 

  • Abramsky, O., Lisak, R. P., Pleasure, D., Gilden, D. H., and Silberger, D. H., 1978, Immunologic characterization of oligodendroglia, Neurosci. Lett. 8: 311–316.

    PubMed  CAS  Google Scholar 

  • Abramsky, O., Lisak, R. P., Silberberg, D. H., Brenner, T., and Pleasure, D., 1979, Immune response to isolated oligodendrocytes, J. Neurol. Sci. 43: 157–167.

    PubMed  CAS  Google Scholar 

  • Agrawal, H. C., and Hartman, B. K., 1980, Proteolipid protein and other proteins of myelin, in: Proteins of the Nervous System, 2nd ed. (R. A. Bradshaw and D. M., Schneider, eds.), pp. 145–169, Raven Press, New York.

    Google Scholar 

  • Agrawal, H. C., Hartman, B. K., Shearer, W. T., Kalmbach, S., and Margolis, F. L., 1977, Purification and immunohistochemical localization of rat brain myelin proteolipid, J. Neurochem. 28: 495–508.

    PubMed  CAS  Google Scholar 

  • Alvord, E. C., Jr., Shaw, C. M., Hruby, S., 1976, Neuro-allergic reactions in primates, in: The Aetiology and Pathogenesis of the Demyelinating Diseases, Proceedings of a symposium held in September 1976 ( H. Shiraki, T. Yonezawa, and Y. Kuroiwa, eds.), pp. 203–216, Japan Science Press, Tokyo.

    Google Scholar 

  • Barbarese, E., and Pfeiffer, S. E., 1981, Developmental regulation of myelin basic protein in dispersed cultures, Proc. Natl. Acad. Sci. U.S.A., 78: 1953–1957.

    PubMed  CAS  Google Scholar 

  • Barbarese, E., Carson, J. H., and Braun, P. E., 1979, Subcellular distribution and structural polymorphism of myelin basic protein in normal and jimpy mouse brain, J. Neurochem. 32: 1437–1446.

    PubMed  CAS  Google Scholar 

  • Baumann, N. (ed.), 1980, Neurological Mutations Affecting Myelination, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Benjamins, J., Guarnieri, M., Miller, K., Sonneborn, M., and McKhann, G. M., 1974, Sulfatide synthesis in isolated oligodendroglial and neuronal cells, J. Neurochem. 23: 751–757.

    PubMed  CAS  Google Scholar 

  • Berg, G., and Schachner, M., 1981, Immuno-electron-microscopic identification of 0-antigenbearing oligodendroglial cells in vitro, Cell Tissue Res. 219: 313–325.

    PubMed  CAS  Google Scholar 

  • Bhat, S., Barbarese, E., and Pfeiffer, S. E., 1981, Requirement for nonoligodendrocyte cell signals for enhanced myelinogenic gene expression in long-term cultures of purified rat oligodendrocytes, Proc. Natl. Acad. Sci. U.S.A., 78: 1283–1287.

    PubMed  CAS  Google Scholar 

  • Bignami, A., and Dahl, D., 1979, The radial glia of Müller in rat retina and their response to injury: An immunofluorescence study with antibodies to the glial fibrillary acidic (GFA) protein, Exp. Eye Res. 28: 63–69.

    PubMed  CAS  Google Scholar 

  • Bird, T. D., Farrell, D. F., ad Sumi, S. M., 1978, Brain lipid composition of the shiverer mouse (genetic defect in myelin development), J. Neurochem. 31: 387–391.

    PubMed  CAS  Google Scholar 

  • Bologa-Sandru, L., Siegrist, H. P., and Herschkowitz, N., 1981a, Immunological properties of bulk isolated mouse oligodendrocytes, Neurosci. Lett. 22: 131–135.

    PubMed  CAS  Google Scholar 

  • Bologa-Sandru, L., Siegrist, H. P., Graggen, A., Hofmann, K., Wiesmann, U., Dahl, D., and Herschkowitz, N., 1981b, Expression of antigenic markers during the development of oligodendrocytes in mouse brain cultures, Brain Res. 210: 217–119.

    PubMed  CAS  Google Scholar 

  • Bologa-Sandru, L., Zalc, B., Herschkowitz, N. and Baumann, N., 1981c, Oligodendrocytes of jimpy mice express galactosylceramide: An immunofluorescence study on brain sections and dissociated brain cell cultures, Brain Res. 225: 425–430.

    PubMed  CAS  Google Scholar 

  • Borit, A., and McIntosh, G. C., 1981, Myelin basic protein and glial fibrillary acidic protein in human fetal brain, Neuropathol. Appl. Neurobiol. 7: 279–287.

    PubMed  CAS  Google Scholar 

  • Bourre, J. M., Jacque, C., Delasalle, A., Nguyen-Legros, J., Dumont, O., Lachaelle, F., Raoul, M., Alvarz, C., and Baumann, N., 1980, Density profile and basic protein measurements in the myelin range of particulate material from normal developing mouse brain and fom neurological mutants (jimpy; quaking; trembler; shiverer and its mid allele) obtained by zonal centrifugation, J. Neurochem. 35: 458–464.

    PubMed  CAS  Google Scholar 

  • Cammer W., Fredman, T., Rose, A. L., and Norton, W. T., 1976, Brain carbonic anhyrase: Activity in isolated myelin and the effect of hexachlorophene, J. Neurochem. 27: 165–171.

    PubMed  CAS  Google Scholar 

  • Cammer, W., Bieler, L., Fredman, T., and Norton, W. T., 1977, Quantitation of myelin carbonic anhydrase: Development and subfractions of rat brain myelin and comparison with myelin from other species, Brain Res. 138: 17–28.

    PubMed  CAS  Google Scholar 

  • Cammer, W., Snyder, D. S., Zimmerman, T. R., Jr., Faroq, M., and Norton, W. T., 1982, Glycerol phosphate dehydrogenase, glucose-6-phosphate dehydrogenase and lactate dehydrogenase: Activities in oligodendrocytes, neurons, astrocytes, and myelin isolated from developing rat brains, J. Neurochem. 38: 360–367.

    PubMed  CAS  Google Scholar 

  • Campagnoni, A. T., and Roberts, J. L., 1976, Isolation of myelin basic proteins from jimpy mice, Brain Res. 115: 351–356.

    Google Scholar 

  • Carson, J. H., Herschkowitz, N. N., and Braun, P. E., 1975, Synthesis and degradation of myelin basic protein in normal and jimpy mouse brain, Trans. Am. Soc. Neurochem. 6: 207.

    Google Scholar 

  • Castiglioni, E. T., and deVellis, J., 1981, Monoclonal antibody to a rat glial cell antigen, Soc. Neurosci. Abstr. 7: 698.

    Google Scholar 

  • Cumming, R., 1981 Immunocytochemistry of second messenger systems, pp. 202–203.

    Google Scholar 

  • Cumming, R., Koide, Y., Krigman, M. R., Beavo, J. A., and Steiner, A. L., 1981, The immunofluorescent localization of regulatory and catalytic subunits of cyclic AMP-dependent protein kinase in neuronal and glial cell types of the central nervous system, Neuroscience 6: 953–961.

    PubMed  CAS  Google Scholar 

  • Delassalle, A., Zalc, B., Lachapelle, F., Raoul, M., Collier, P., and Jacque, C., 1981, Regional distribution of myelin basic protein in the central nervous system of quaking, jimpy, and normal mice during development and aging, J. Neurosci. Res. 6: 303–313.

    PubMed  CAS  Google Scholar 

  • Delaunoy, J. P., Roussel, G., Nussbaum, J. L., and Mandel, P., 1977, Immunohistochemical studies of Wolfgram proteins in central nervous system of neurological mutant mice, Brain Res. 133: 29–36.

    PubMed  CAS  Google Scholar 

  • Delaunoy, J. P., Hog, F., Devilliers, G., Bansart, M., Mandel, P., and Sensenbrenner, M., 1980, Developmental changes and localization of carbonic anhydrase in cerebral hemispheres of the rat and in rat glial cell cultures, Cell Mole. Biol. 26: 235–240.

    CAS  Google Scholar 

  • del Cerro, C., Sternberger, N. H., Kies, M. W., and Herndon, R. M., 1983, Immunocytochemistry of myelin basic protein in adult oligodendroglia, Soc. Neurosci. Abstr. 9: 451.

    Google Scholar 

  • Drummond, R. J., and Dean, G., 1980, Comparison of 2’,3’-cyclic nucleotide 3’-phosphohyrolase and the major component of Wolfgram protein W1, J. Neurochem. 35: 1155–1165.

    PubMed  CAS  Google Scholar 

  • Dupouey, P., Jacque, C., Bourre, J. M., Cesseliln, F., Privat, A., and Baumann, N., Immunocytochemical studies of a myelin basic protein in Shiverer mouse devoid of major 1979a, Neurosci. Lett. 12: 113–118.

    PubMed  CAS  Google Scholar 

  • Dupouey, P., Zalo, B., Lefroit-Joly, M., and Gomes, D., 19796, Localization of galactosylceramide and sulfatide at the surface of the myelin sheath: An immunofluorescence study in liquid medium, Cell. Mol. Biol. 25: 269–272.

    Google Scholar 

  • Dupouey, P., Lucas, C., Gomes, D., and Jacque, C., 1980a, Immunochistochemical localization of the MBP and of the GFAP: Comparative study in normal, quaking and jimpy mice, J. Neurosci. Res. 5: 387–398.

    PubMed  CAS  Google Scholar 

  • Dupouey, P., Gomes, D., Raoul, M., Collier, P., and Jacque, C., 1980b, Abnormal myelination in the mouse: Immunohistochemical investigation on the quaking, jimpy and shiverer mutants, in: Neurological Mutations Affecting Myelination (N. Baumann, ed.), INSERM Symposium No. 14, pp. 327–332, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Eng. L. F., and Bigbee, J. W., 1978, Immunohistochemistry of nervous system specific antigens, in: Advances in Neurochemistry, Vol. 3 ( B. W. Agronoff and M. H. Aprison, eds.), pp. 4398, Plenum Press, New York.

    Google Scholar 

  • Eng, L. F., and DeArmond, S. J., 1982, Immunochemistry of the glial fibrillary acidic (GFA) protein, in: Progress in Neuropathology ( H. M. Zimmerman, ed.), Raven Press, New York.

    Google Scholar 

  • Eng, L. F., Burkstaller, M., Bigbee, J., Kosek, J. C., and Kies, M. W., 1975, Immunohistologic comparison of the glial fibrillary acidic protein and myelin basic protein in the myelinating brain, 5th International Meeting of the International Society of Neurochemists, Barcelona, Spain, Abstract 41.

    Google Scholar 

  • Fagg, G. E., Lane, J. D., Neuhoff, V., and Waehneldt, T. V., 1979, Carbonic anhydrase activity in myelin fractions from rat optic nerves, Neurosci. Lett. 12: 219–222.

    PubMed  CAS  Google Scholar 

  • Farkas-Bargeton, E., Robain, O., and Mandel, P., 1972, Abnormal glial maturation in the white matter in jimpy mice, Acta Neuropathol. (Berlin) 21: 272–281.

    CAS  Google Scholar 

  • Fisher, M., Gapp, D. A., and Kozak, L. P., 1981, Immunocytochemical localization of sn-glycerol-3-phosphate dehydrogenase in Bergmann glia and oligodendroglia in the mouse cerebellum, Del. Brain Res. 1: 341–354.

    Google Scholar 

  • Ganser, A. L., and Kirschner, D. A., 1979, Compact myelin exists in the absence of basic protein in the shiverer mouse, Nature (London), 283: 207–210.

    Google Scholar 

  • Gebicke-Harter, P. J., Althaus, H. H., Schwartz, P., and Neuhoff, V., 1981, Oligodendrocytes from postnatal cat brain in cell culture. I. Regeneration and maintenance, Dev. Brain Res. 1: 497–518.

    Google Scholar 

  • Ghandour, M. S., Langley, O. K., Vincendon, G., and Gombos, G., 1979, Double labeling immunohistochemical technique provides evidence of the specificity of glial cell markers, J. Histochem. 27: 1634–1637.

    CAS  Google Scholar 

  • Ghandour, M. S., Langley, O. K., Vincendon, G., Gombos, G., Filippi, D., Limozin, N., Dal-masso, C., and Laurent, G., 1980a, Immunochemical and immunohistochemical study of carbonic anhydrase II in adult rat cerebellum: A marker for oligodendrocytes, Neuroscience 5: 559–571.

    PubMed  CAS  Google Scholar 

  • Ghandour, M. S., Vincendon, G., and Gombos G., 1980b, Astrocyte and oligodendrocyte distribution in adult rate cerebellum: An immunohistological study, J. Neurocytol. 9: 637–646.

    PubMed  CAS  Google Scholar 

  • Ghandour, M. S., Vincendon, G., Gombos, G., Limozin, N., Filippi, D., Dalmasso, C., and Laurent, G., 1980c, Carbonic anhydrase and oligodendroglia in developing rat cerebellum: A biochemical and immunohistological study, Dey. Biol. 77: 73–83.

    CAS  Google Scholar 

  • Ghandour, M. S., Derer, P., Labourdette, G., Delaunoy, J. P., and Langley, O. K., 1981, Glial cell markers in the reeler mutant mouse: A biochemical and immunohistological study, J. Neurochem. 36: 195–200.

    PubMed  CAS  Google Scholar 

  • Giacobini, E., 1961, Localization of carbonic anhydrase in the nervous system, Science 134: 1524–1525.

    PubMed  CAS  Google Scholar 

  • Giacobini, E., 1962, A cytochemical study of the localization of carbonic anhydrase in the nervous system, J. Neurochem. 9: 169–177.

    PubMed  CAS  Google Scholar 

  • Goldstein, M. E., Sternberger, L. A., and Sternberger, N. H., 1982, Developmental expression of neurotypy revealed by immunocytochemistry with monoclonal antibodies, J. Neuroimmunol. 3: 203–217.

    PubMed  CAS  Google Scholar 

  • Goldstein, M. E., Sternberger, L. A., and Sternberger, N. H., 1983, Microheterogeneity (“neurotypy”) of neurofilament proteins, Proc. Natl. Acad. Sci. U.S.A. 80: 3101–3105.

    PubMed  CAS  Google Scholar 

  • Hartman, B. K., Agrawal, H. C., Kalmback, S., and Shearer, W. T., 1979, A comparative study of the immunohistochemical localization of basic protein to myelin and oligodendrocytes in rat and chicken brain, J. Comp. Neurol. 188: 273–290.

    PubMed  CAS  Google Scholar 

  • Hartman, B. K., Agrawal, H. C., Agrawal, D., and Kalmbach, S., 1982, Development and maturation of central nevous system myelin: Comparison of immunohistochmical localization of proteolipid protein and basic protein in myelin and oligodendrocytes, Proc. Natl. Acad. Sci. U.S.A. 79: 4217–4220.

    PubMed  CAS  Google Scholar 

  • Herndon, R. M., Rauch, H. C., and Einstein, E. R., 1973, Immuno-electron microscopic locali- zation of the encephalitogenic basic protein in myelin, Immunol. Commun. 2: 163–172.

    PubMed  CAS  Google Scholar 

  • Hirano, A., Sax, D. S., and Zimmerman, H. M., 1969a, The fine structure of the cerebella of jimpy mice and their “normal” litter mates, J. Neuropathol. Exp. Neurol. 28: 388–400.

    PubMed  CAS  Google Scholar 

  • Hirano, A., Becker, N. H., and Zimmerman, H. M., 1969b, Isolation of the periaxonal space of the central myelinated nerve fiber with regard to the diffusion of peroxidase, J. Histochem. Cytochem. 17: 512–516.

    PubMed  CAS  Google Scholar 

  • Hogan, E. L., 1977, Animal models of genetic disorders of myelin, in: Myelin ( P. Morel, ed.), pp. 489–520, Plenum Press, New York.

    Google Scholar 

  • Inoue, Y., Sugihara, Y., Nakagawa, S., and Shimai, K., 1973, The morphological changes of oligodendroglia during the formation of myelin sheaths: Golgi study and electron microscopy, Okajimas Fol. Anat. Jap. 50: 327–344.

    CAS  Google Scholar 

  • Inoue, Y., Nakamura, R., Mikoshiba, K., and Tsukada, Y., 1981, Fine structure of the central myelin sheath in the myelin deficient mutant shiverer mouse, with special reference to the pattern of myelin formation by oligodendroglia, Brain Res. 219: 85–94.

    PubMed  CAS  Google Scholar 

  • Itoyama, Y., Sternberger, N. H., Kies, M. W., Cohen, S. R., Richardson, E. P., Jr., and Webster, H. de F., 1980a, Immunocytochemical method to identify myelin basic protein in oligodendroglia and myelin sheaths of the human nervous system, Ann. Neurol. 7: 157–166.

    PubMed  CAS  Google Scholar 

  • Itoyama, Y., Sternberger, N. H., Webster, H. de F., Quarles, R. H.,Cohen, S. R., and Richardson, E. P., Jr., 1980b, Immunocytochemical observations on the distribution of myelin-associated glycoprotein and myelin basic protein in multiple sclerosis lesions, Ann. Neurol. 7: 167–177.

    PubMed  CAS  Google Scholar 

  • Jacque, C., Privat, A., Dupouey, P., Bourre, J. M., Bird, T. D., and Baumann, N., 1978, Shiverer mouse: A dysmyelinating mutant with absence of major dense line and basic protein in myelin in: 2nd European Society of Neurochemistry Meeting, Proc. Europ. Soc. Neurochem., Vol. 1 (V. Neuhoff, ed.) p. 131, Verlag Chemie, Wiesbaden.

    Google Scholar 

  • Johnson, A. B., and Blum, N. R., 1972, Peroxidase-labeled antigens in light and electron immunohistochemistry and their utilization in studies of experimental allergic encephalomyelitis, Abst. Histocem. Soc. 7: 841.

    Google Scholar 

  • Johnson, A. B., Wisniewski, H. M., Raine, C. S., Eylar, E. H., and Terry, R. D., 1971, Specific binding of peroxidase-labeled myelin basic protein in allergic encephalomyelitis, Proc. Natl. Acad. Sci. U.S.A. 68: 294–2698.

    Google Scholar 

  • Jones, E. G., and Hartman, B. K., 1978, Recent advances in neuroanatomical methodology, Annu. Rev. Neurosci. 1: 215–296.

    PubMed  CAS  Google Scholar 

  • Kennedy, P. G. E., and Lisak, R. P., 1979, A search for antibodies against glial cells in the serum and cerebrospinal fluid of patients with multiple sclerosis and Guillain—Barré syndrome, J. Neurol. Sci. 44: 125–133.

    PubMed  CAS  Google Scholar 

  • Kies, M. W., 1982, Myelin basic protein, Scand. J. Immunol. 15: 125–146.

    Google Scholar 

  • Kies, M. W., Thompson, E. B., and Alvord, E. C., Jr., 1965, The relationship of myelin proteins to experimental allergic encephalomyelitis, Ann. N. Y. Acad. Sci. 122: 148–160.

    PubMed  CAS  Google Scholar 

  • Kimelberg, H. K., Stieg, P. E., and Mazurkiewicz, J. E., 1982, Immunocytochemical and biochemical analysis of carbonic anhydrase in primary astrocyte cultures from rat brain, J. Neurochem. 39: 734–742.

    PubMed  CAS  Google Scholar 

  • Kristt, D. A., and Butler, F. K., 1978, Neuronal abnormalities associated with impaired myelination during brain development: A Golgi study of neocortex in the jimpy mouse, Neurosci. Lett. 7: 107–113.

    PubMed  CAS  Google Scholar 

  • Kohler, G., and Milstein, C., 1975, Continuous cultures of fused cells secreting antibody of predefined specificity, Nature (London) 256: 495–497.

    CAS  Google Scholar 

  • Kohler, J. G., and Milstein, C., 1976, Derivation of specific antibody producing tissue culture and tumor lines by cell fusion, Eur. J. Immunol. 6: 511

    PubMed  CAS  Google Scholar 

  • Korhonen, L. K., Naatanen, E., and Hyppa, M., 1964, A histochemical study of carbonic anhydrase in some parts of the mouse brain, Acta Histochem. 18: 336–347.

    PubMed  CAS  Google Scholar 

  • Kornguth, S. E., Anderson, J. W., and Scott, G., 1966, Temporal relationship between myelinogenesis and the appearance of basic protein in the spinal cord of the white rat, J. Comp. Neurol. 127: 1–18.

    PubMed  CAS  Google Scholar 

  • Kraus-Ruppert, R., Herschkowitz, N., and Furst, H., 1973, Morphological studies on neuroglial cells in the corpus callosum of the jimpy mouse, J. Neuropathol. Exp. Neurol. 32: 197–203.

    PubMed  CAS  Google Scholar 

  • Kumpulainen, T., 1980, Carbonic anhydrase isoenzyme C in the human retina, Acta Ophthalmol. 58: 397–405.

    CAS  Google Scholar 

  • Kumpulainen, T., and Korhonen, L. K., 1982, Immunohistochemical localization of carbonic anhydrase isoenzyme C in the central and peripheral nervous system of the mouse, J. Histochem. Cytochem. 30: 283–292.

    PubMed  CAS  Google Scholar 

  • Kumpulainen, T., and Nystrom, S. H. M., 1981, Immunohistochemical localization of carbonic anhydrase isoenzyme C in human brain, Brain Res. 220: 220–225.

    PubMed  CAS  Google Scholar 

  • Langley, O. K., Ghandour, M. S., Vincendon, G., and Gombos, C., 1980, Carbonic anhydrase: An ultrastructural study in rat cerebellum, Histochem. J. 12: 473–483.

    PubMed  CAS  Google Scholar 

  • Lennon, V. R., Wittingham, J., Carnegie, P. R., McPherson, T. A., and MacKay, I. R., 1971, Detection of antibodies to the basic protein of human myelin by radioimmunoassay and immunofluorescence, J. Immunol. 107: 56–62.

    PubMed  CAS  Google Scholar 

  • Leveille, P. J., McGnnis, J. F., Maxwell, D. S., and de Vellis, J., 1980, Immunocytochemical localization of glycerol-3-phosphate dehydrogenase in rat oligodendrocytes, Brain Res. 196: 287–305.

    PubMed  CAS  Google Scholar 

  • Lisak, R. P., Abramsky, O., Dorfman, S. H., George, J., Manning, M. C., Pleasure, D. E., Saida, T., and Silberberg, D. H., 1979, Antibodies to galactocerebrosde bind to oligodendroglia in suspension culture, J. Neurol. Sci. 40: 65–73.

    PubMed  CAS  Google Scholar 

  • Lisak, R. P., Pruss, R. M., Kennedy, P. G. E., Abramsky, O., Pleasure, D. E., and Silberberg, D. H., 1981, Antisera to bovine oligodendroglia raised in guinea pigs bind to surface of rat oligodendroglia and Schwann cells, Neurosci. Lett. 17: 119–124.

    Google Scholar 

  • Ludwin, S. K., 1979, The perineuronal satellite oligodendrocyte: A role in remyelination, Acta Neuropathol. 47: 49–53.

    PubMed  CAS  Google Scholar 

  • Ma, B. I., Joseph, B. S., Wash, M. J. Potvin, A. R., and Tourtellotte, W. W., 1981, Multiple sclerosis serum and cerebrospinal fluid immunoglobulin binding to Fc receptors of oligodendrocytes, Ann. Neurol. 9: 371–377.

    CAS  Google Scholar 

  • Matthieu, J. M., Widmer, S., and Herschkowitz, N., 1973, Jimpy, an anomaly of myelin maturation: Biochemical studies of myelination phases, Brain Res. 55: 403–412.

    PubMed  CAS  Google Scholar 

  • Matthieu, J. M., Quarles, R. H., Webster, H. de F., Hogan, E. L., and Brady R. 0., 1974, Characterization of the fraction obtained from the CNS of jimpy mice by a procedure for myelin isolation, J. Neurochem. 23: 517–523.

    PubMed  CAS  Google Scholar 

  • McCarthy, K. D., and de Vellis, J., 1980, Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue, J. Cell Biol. 85: 890–902.

    PubMed  CAS  Google Scholar 

  • Meier, C., and Bischoff, A., 1975, Oligodendroglial cell development in jimpy mice and controls: An electron microscopic study in the optic nerve, J. Neurol. Sci. 26: 517–528.

    PubMed  CAS  Google Scholar 

  • Meier, C., Herschkowitz, N., and Bischoff, A., 1974, Morphological and biochemical observations in the jimpy spinal cord, Acta Neuropathol. 27: 349–362.

    PubMed  CAS  Google Scholar 

  • Mendell, J. R., and Whitaker, J. N., 1978, Immunocytochemical localization studies of myelin basic protein, J. Cell Biol. 76: 502–511.

    PubMed  CAS  Google Scholar 

  • Mirsky, R., Winter, J., Abney, E. R., Pruss, R. M., Gavrilovic, J., and Raff, M. C., 1980, Myelin-specific proteins and glycolipids in rat Schwann cells and oligodendrocytes in culture, J. Cell Biol. 84:483–494-

    Google Scholar 

  • Mori, S., and LeBlond, C. P., 1970, Electron microscopic identification of three classes of oligodendrocytes and a preliminary study of their proliferative activity in the corpus callosum of young rats, J. Comp. Neurol. 139: 1–30.

    PubMed  CAS  Google Scholar 

  • Müller, H. W., Clapshaw, P. A., and Seifert, W., 1981, Intracellular localization of 2’,3’-cyclic nucleotide 3’-phosphodiesterase in a neuronal cell line as examined by immunofluorescence and cell fractionation, J. Neurochem. 37: 947–955.

    PubMed  Google Scholar 

  • Narang, H. K., 1977, Electron microscopic development of neuroglia in epiretinal portion of postnatal rabbits, J. Neurol. Sci. 34: 391–406.

    PubMed  CAS  Google Scholar 

  • Narang, H. K., and Wisniewski, H. M., 1976, The sequence of myelination in the epiretinal portion of the optic nerve in the rabbit, Neuropathol. Appl. Neurobiol. 3: 15–27.

    Google Scholar 

  • Nishizawa, Y., Kurihara, T., and Takahashi, Y., 1981, Immunohistochemical localization of 2’,3’-cyclic nucleotide 3’-phosphodiesterase in the central nervous system, Brain Res. 212: 219–222.

    PubMed  CAS  Google Scholar 

  • Norton, W. T., 1981, Biochemistry of myelin, in: Demyelinating Disease: Basic and Clinical Electrophysiology ( S. G. Waxman and J. M. Ritchie, eds.) pp. 93–121, Raven Press, New York.

    Google Scholar 

  • Nussbaum, J. L., Delaunoy, J. P., and Mandel, P., 1977, Some immunochemical characteristics of W1 and W2 Wolfgram proteins isolated from rat brain myelin, J. Neurochem. 28: 183–191.

    PubMed  CAS  Google Scholar 

  • O’Dowd, D. K., and Eng, L. F., 1979, Immunocytochemical localization of the glial fibrillary acidic (GFA) protein in the Müller cell of the human retina, Neurosci. Abstr. 5: 14–56.

    Google Scholar 

  • Omlin, F. X., Palkovits, C. G., Cohen, S. R., and Webster, H. de F., 1982a, EM immunocytochemistry of basic protein in developing glia and myelin, Trans. Am. Soc. Neurochem. 13: 214.

    Google Scholar 

  • Omlin, F. X., Webster, H. de F., Palkovits, C. G., and Cohen, S. R., 1982b, Immunocytochemical localization of basic protein in major dense line regions of central and peripheral myelin, J. Cell Biol. 95: 242–248.

    PubMed  CAS  Google Scholar 

  • Peng, W. W., Cole, R., and de Vellis, J., 1981, A monoclonal antibody to oligodendrocytes, Soc. Neurosci. Abstr. 7: 698.

    Google Scholar 

  • Pfeiffer, S. E., Barbarese, E., and Bhat, S., 1981, Noncoordinate regulation of myelinogenic parameters in primary cultures of dissociated fetal rat brain, J. Neurosci. Res. 6: 369–380.

    PubMed  CAS  Google Scholar 

  • Pleasure, D., Hardy, M., Johnson, G., Lisak, R., and Silberberg, D., 1981, Oligodendroglial glycerophospholipid synthesis: Incorporation of radioactive precursors into ethanolamin glycerophospholipids by calf oligodendroglia prepared by a Percoll procedure and maintained in suspension culture, J. Neurochem. 37: 452–460.

    PubMed  CAS  Google Scholar 

  • Poduslo, S. E., McFarland, H. F., and McKhann, G. M., 1977, Antiserums to neurons and to oligodendroglia from mammalian brain, Science 197: 270–272.

    PubMed  CAS  Google Scholar 

  • Prineas, J. W., and Graham, J. S., 1981, Multiple sclerosis; Capping of surface immunoglobulin G on macrophages engaged in myelin breakdown, Ann. Neurol. 10: 149–158.

    PubMed  CAS  Google Scholar 

  • Privat, A., and LeBlond, C. P., 1972, The subependymal layer and neighboring region in the brain of the young rat, J. Comp. Neurol. 146: 277–302.

    PubMed  CAS  Google Scholar 

  • Privat, A., Robain, O., and Mandel, P., 1972, Aspects ultrastructuraux du corps calleux chez la souris jimpy, Acta Neuropathol. 21: 282–295.

    PubMed  CAS  Google Scholar 

  • Privat, A., Jacque, C., Bourre, J. M., Dupouey, P., and Baumann, N., 1979, Absence of the major dense line in myelin of the mutant mouse “shiverer,” Neurosci. Lett. 12: 107–112.

    PubMed  CAS  Google Scholar 

  • Pruss, R. M., Bartlett, P. F., Gavrilovic, J., Lisak, R. P., and Rattray, S., 1982, Mitogens for glial cells: A comparison of the response of cultured astrocytes, oligodendrocytes and Schwann cells, Dev. Brain Res. 2: 19–35.

    Google Scholar 

  • Quarles, R. H., 1979, Glycoproteins in myelin and myelin-related membranes, in: Complex Carbohydrates of Nervous Tissue ( R. U. Margolis and R. K. Margolis, eds.) pp. 209–233, Plenum Press, New York.

    Google Scholar 

  • Raff, M. C., Mirsky, R., Fields, K. L., Lisak, R. P., Dorfman, S. H., Silberberg, D. H., Gregson, N. A., Leibowitz, S., and Kennedy, M. C., 1978, Galactocerebroside is a specific cell-surface antigenic marker for oligodendrocytes in culture,Nature (London) 274: 813–816.

    CAS  Google Scholar 

  • Raff, M. C., Fields, K. L., Hakamori, S. I., Mirsky, R., Pruss, R. M., and Winter, J., 1979, Celltype-specific markers for distinguishing and studying neurons and the major classes of glial cells in culture, Brain Res. 174: 283–308.

    PubMed  CAS  Google Scholar 

  • Raine, C. S., 1981, Neurocellular anatomy, in: Basic Neurochemistry ( G. J. Siegel, R. W. Albers, B. W. Agranoff, and R. Katzman, eds.), pp. 21–47, Little, Brown, Boston.

    Google Scholar 

  • Ramon-Moliner, E., 1958, A study on neuroglia: The problem of transitional forms, J. Comp. Neurol. 110: 157–167.

    CAS  Google Scholar 

  • Ranscht, B., Clapshaw, P. A., Price, J., Noble, M., and Seifert, W., 1982, Development of oligodendrocytes and Schwann cells studied with a monoclonal antibody against galactocerebroside, Proc. Natl. Acad. Sci. U.S.A 79: 2709–2713.

    PubMed  CAS  Google Scholar 

  • Rauch, H. C., and Raffel, S., 1964, Immunofluorescent localization of encephalitogenic protein in myelin, J. Immunol. 92: 2452–455.

    Google Scholar 

  • Reiss, D. S., Lees, M. B., and Sapirstein, V. S., 1981, Is Na + K ATPase a myelin-associated enzyme?, J. Neurochem. 36: 1418–1426.

    PubMed  CAS  Google Scholar 

  • Roussel, G., and Nussbaum, J. L., 1981, Comparative localization of Wolfgram W1 and myelin basic proteins in the rat brain during ontogenesis, Histochem. J. 13: 1029–1047.

    PubMed  CAS  Google Scholar 

  • Roussel, G., and Nussbaum, J. L., 1982, Surface labeling of oligodendrocytes with anti-myelin serum in cell cultures from the rat brain, Cell Tissue Res. 225: 581–594.

    PubMed  CAS  Google Scholar 

  • Roussel, G., Delaunoy, J. P., Nussbaum, J. L., and Mandel, P., 1977, Immunohistochemical localization of Wolfgram proteins in nervous tissue of rat brain, Neuroscience 2: 307–313.

    PubMed  CAS  Google Scholar 

  • Roussel, G., Delaunoy, J. P., Mandel, P., and Nussbaum, J. L., 1978, Ultrastructural localization study of two Wolfgram proteins in rat brain tissue, J. Neurocytol. 7: 155–163.

    PubMed  CAS  Google Scholar 

  • Roussel, G., Delaunoy, J. P., Nussbaum, J. L., and Mandel, P., 1979, Demonstration of a specific localization of carbonic anhydrase C in the glial cells of rat CNS by an immunohistochemical method, Brain Res. 160: 47–55.

    PubMed  CAS  Google Scholar 

  • Roussel, G., Labourdette, G., and Nussbaum, J. L, 1981, Characterization of oligodendrocytes in primary cultures from brain hemispheres of newborn rats, Dev. Biol. 81: 371–378.

    Google Scholar 

  • Sandru, L., Siegrist, H. P., Wiesmann, U. N., and Herschkowitz, N., 1980, Development of oligodendrocytes in jimpy brain cultures, in: Neurological Mutations Affecting Myelination (N. Baumann, ed.) INSERM Symposium No. 14, pp. 469–474, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Sapirstein, V. S., Lees, M. B., and Trachtenberg, M. C., 1978, Soluble and membrane bound carbonic anhydrase from rat CNS: Regional development, J. Neurochem. 31: 283–287.

    PubMed  CAS  Google Scholar 

  • Sarlieve, L. L., Fabare, M., Delaunoy, J. P., Pieringer, R. A., and Rebel, G., 1980, Surfaceadhering primary cultures of dissociated brain cells from embryonic mice as a tool to study myelination in vitro, in: Neurological Mutations Affecting Myelination (N. Baumann, ed.), INSERM Symposium No. 14, pp. 489–500, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Sarlieve, L. L. Delaunoy, J. P., Dierich, A., Ebel, A., Fabre, M., Mandel, P., Rebel, G., Vincendon, G., Wintzerith, M., and Yusufi, A. N. K., 1981, Investigations on myelination in vitro. III. Ultrastructural: Brain cells from embryonic mice, J. Neurosci. Res. 6: 659–683.

    PubMed  CAS  Google Scholar 

  • Schachner, M, Kim, S. K., and Zehnle, R., 1981, Developmental expresson in central and peripheral nervous system of oligodendrocyte cell surface antigens (0 antigens) recognized by monoclonal antibodies, Dev. Biol. 83: 328–338.

    PubMed  CAS  Google Scholar 

  • Sidman, R. L., and Hayes, R., 1965, Jimpy: A mouse with inherited sudanophilic leukodystrophy, J. Neuropathoi. Exp. Neurol. 24: 172.

    Google Scholar 

  • Sires, L. R., Hruby, S., Alvord, E. C., Jr., Hellström, I., Hellström, K. E., Kies, M. W., Martenson, R., Diebler, C. E., Beckman, E. D., and Casnellie, J. E., 1981, Species restrictions of a monoclonal antibody reacting with residues 130 to 137 in encephalitogenic myelin basic protein, Science 214: 87–89.

    PubMed  CAS  Google Scholar 

  • Skoff, R. P., 1976, Myelin deficits in the jimpy mouse may be due to cellular abnormalities in astroglia, Nature (London) 264: 560–562.

    CAS  Google Scholar 

  • Skoff, R. P., Price, D. L., and Stocks, A., 1976, Electron microscopic autoradiographic studies of gliogenesis in rat optic nerve. II. Time of origin, J. Comp. Neurol. 169: 313–333.

    PubMed  CAS  Google Scholar 

  • Snyder, D. S., and Whitaker, J. N., 1982, Immunocytochemical localization of cathepsin in rat CNS during ontogeny, Trans. Am. Soc. Neurochem. 13: 115.

    Google Scholar 

  • Snyder, D. S., Raine, C. S., Farooq, M., and Norton, W. T., 1980, The bulk isolation of oligodendroglia from whole rat forebrain: A new procedure using physiologic media, J. Neuro-chem. 34: 1614–1621.

    CAS  Google Scholar 

  • Sommer, I., and Schachner, M., 1981, Monoclonal antibodies (01 to 04) to oligodendrocyte cell surfaces: An immunocytological study in the central nervous system, Dev. Biol. 83: 311–327.

    PubMed  CAS  Google Scholar 

  • Sotelo, C., 1980, Mutant mice and the formtion of cerebellar circuitry, pp. 33–35.

    Google Scholar 

  • Spicer, S. S., Stoward, P. J., and Tashian, R. E., 1979, The immunohistolocalization of carbonic anhydrase in rodent tissues, J. Histochem. Cytochem. 27: 820–831.

    PubMed  CAS  Google Scholar 

  • Sprinkle, T. J., and McDonald, T. F., 1982, Immunofluorescence in oligodendrocytes treated with anti-CNP antisera, Trans. Am. Soc. Neurochem. 13: 172.

    Google Scholar 

  • Sprinkle, T. J., Wells, M. R., Garver, F. A., and Smith, D. B., 1980, Studies on the Wolfgram high molecular weight CNS myelin proteins: Relationship to 2’,3’-cyclic nucleotide 3’-phosphodiesterase, J. Neurochem. 35: 1200–1208.

    PubMed  CAS  Google Scholar 

  • Sprinkle, T. J., Baker, M. D., and McDonald, T. F., 1981, Immunocytochemical localization of CNP in adult bovine optic nerve, Trans. Am. Soc. Neurochem. 12: 209.

    Google Scholar 

  • Sternberger, N., Tabira, T., Kies, M. W., and Webster, H., 1977, Immunocytochemical staining of basic protein CNS myelin, Trans. Am. Soc. Neurochem. 8: 157.

    Google Scholar 

  • Sternberger, N. H., Itoyama, Y., Kies, M. W., and Webster, H., de F., 1978a, Immunocytochemical method to identify basic protein in myelin-forming oligodendrocytes of newborn rat C.N.S., J. Neurocytol. 7: 251–263.

    PubMed  CAS  Google Scholar 

  • Sternberger, N. H., Itoyama, Y., Kies, N. W., and Webster, H.F., 1978b, Myelin basic protein demonstrated immunocytochemically in oligodendroglia prior to myelin sheath formation, Proc. Natl. Acad. Sci. U. S. A. 75: 2521–2524.

    PubMed  CAS  Google Scholar 

  • Sternberger, N. H., Quarles, R. H., Itoyama, Y., and Webster, H.F., 1979a, Myelin-associated glycoprotein demonstrated immunocytochemically in myelin and myelin-forming cells of developing rat, Proc. Natl. Acad. Sci. U. S. A. 76: 1510–1514.

    PubMed  CAS  Google Scholar 

  • Sternberger, N. H., Quarles, R. H., Cohen, S. R., Winchell, K., and Webster, H. de F., 19796 Alterations in myelin basic protein and myelin-associated glycoprotein in jimpy mice, Soc. Neurosci. Abstr.,p. 417.

    Google Scholar 

  • Szuchet, S., Stefannson, K., Wollmann, R. L., Dawson, G., and Arnason, B. G., 1980, Maintenance of isolated oligodendrocytes in long-term culture, Brain Res. 200: 151–164.

    PubMed  CAS  Google Scholar 

  • Tennekoon, G. I., Frangia, J., Aitchison, S., and Price, D. L., 1981, Cerebroside sulfotransferase: Preparation of antiboyd and localization of antigen in Kidney, J. Cell Biol. 91: 332–339.

    PubMed  CAS  Google Scholar 

  • Towbin, H., Staehelin, T., and Gordon, J., 1979, Electrophoretic transfer of proteins from poly-acrylamide gels to nitrocellulose sheets: Procedure and some applications, Proc. Natl. Acad. Sci. U. S.A. 76: 4350–4354.

    PubMed  CAS  Google Scholar 

  • Traugott, U., and Raine, C. S., 1981, Antioligodendrocyte antibodies in cerebrospinal fluid of multiple sclerosis and other neurologic diseases, Neurology 31: 695–700.

    PubMed  CAS  Google Scholar 

  • Traugott, U., Snyder, D. S., Norton, W. T., and Raine, C. S., 1978, Characterization of antioligodendrocyte serum, Ann. Neurol. 4: 431–439.

    PubMed  CAS  Google Scholar 

  • Traugott, U., Snyder, D. S., and Raine, C. S., 1979, Oligodendrocyte staining by multiple sclerosis serum is nonspecific, Ann. Neurol. 6: 13–20.

    PubMed  CAS  Google Scholar 

  • Whitaker, J. N., 1975, The antigenicity of mylin encephalitogenic protein: Production of antibodies to encephalitogenic protein with deoxyribonucleic acid—encephalitogenic protein complexes, J. Immunol. 114: 823–828.

    PubMed  CAS  Google Scholar 

  • Whitaker, J. N., 1978, The distribution of myelin basic protein in central nervous system lesions of multiple sclerosis and acute experimental allergic encephalomyelitis, Ann. Neurol. 3: 291–298.

    PubMed  CAS  Google Scholar 

  • Whitaker, J. N., Terry, L. C., and Whetsell, W. O., Jr., 1981, Immunocytochemical localization of cathepsin D in rat neural tissue, Brain Res. 216: 109–124.

    PubMed  CAS  Google Scholar 

  • Wolfgram, F., 1966, A new proteolipid fraction of the nervous system. I. Isolation and amino acid analyses J. Neurochem. 35: 461–470.

    Google Scholar 

  • Wood, J. G., Jean, D. H., Whitaker, J. N., McLaughlin, B. J., and Albers, R. W., 1977, Immu-nocytochemical localization of the sodium, potassium activated ATPase in knifefish brain, J. Neurocytol. 6: 571–581.

    PubMed  CAS  Google Scholar 

  • Yandrasitz, J. R., Ernst, S. A., and Salganicoff, L., 1976, The subcellular distribution of carbonic anhydrase in homogenates of perfused rat brain, J. Neurochem. 17: 707–715.

    Google Scholar 

  • Zalc, B., Monge, M., and Baumann, N., 1980 Immunohistochemical localization of galactosylceramide and sulfogalactosylceramide in the cerebellum of the quaking, shiverer and jimpy mice, in: Neurological Mutations Affecting Myelination, (N. Baumann, ed.), INSERM Symposium No. 14, pp. 263–268, Elsevier/North-Holland, Amsterdam.

    Google Scholar 

  • Zalc, B., Monge, M., Dupouey, P., Hauw, J. J., and Baumann, N. A., 1981, Immunohistochemical localation of glactosyl and sulfogalactosyl ceramide in the brain of the 30-day-old mouse, Brain Res. 211: 341–354.

    PubMed  CAS  Google Scholar 

  • Zimmerman, T. R., Jr., and Cohen, S. R., 1979, The distribution of myelin basic protein in subcellular fractions of developing jimpy mouse brain, J. Neurochem. 32: 817–821.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer Science+Business Media New York

About this chapter

Cite this chapter

Sternberger, N.H. (1984). Patterns of Oligodendrocyte Function Seen by Immunocytochemistry. In: Norton, W.T. (eds) Oligodendroglia. Advances in Neurochemistry, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-6066-8_4

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-6066-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-6068-2

  • Online ISBN: 978-1-4757-6066-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics