In Vivo Metabolism of Oligodendroglial Lipids

  • Pierre Morell
  • Arrel D. Toews
Part of the Advances in Neurochemistry book series (ANCH, volume 5)


A basic assumption for studies of in vivo lipid metabolism in oligodendroglial cells is that the metabolism of lipids in myelin reflects the activity of these glial cells. This is not a trivial assumption. The cytoplasmic connection between the oligodendroglial cell perikaryon and myelin can be visualized in the developing CNS (Bunge, 1968). However, “connections between these elements have never been demonstrated in a normal adult animal, unlike the PNS counterpart, the Schwann cell” (Raine, 1981). Nevertheless, it is generally assumed that metabolism of the mature myelin sheath (which, as will be documented below, is reasonably vigorous) requires extensive contact with elements of the oligodendroglial-cell perikaryon through cytoplasmic channels. These connections may not be easy to visualize; due to their tortuous courses, it is unlikely that a thin section prepared for electron microscopy will include the complete channel (see Chapter 1 for further discussion).


Myelin Sheath Ketone Body Myelin Protein Oligodendroglial Cell Myelin Membrane 
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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Pierre Morell
    • 1
  • Arrel D. Toews
    • 1
  1. 1.Department of Biochemistry and Nutrition and Biological Sciences Research CenterUniversity of North Carolina at Chapel HillChapel HillUSA

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