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The New Dimensions of Warfarin Prophylaxis pp 113–129Cite as

Cold-Promoted Activation of Factor VII and Shortening of the Prothrombin Time

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Abstract

The previous speakers have summarized our knowledge concerning the biochemistry, function, synthesis and molecular biology of the coagulation factors II, VII, IX, X, and protein C and S. In particular, they have highlighted the role of the gamma carboxyglutamic acid, the biosynthetic rates and the specific steps in the activation of these proteins. This has led to a clear understanding of the biologic effect of the vitamin K antagonists. The studies of tissue factor have elucidated various aspects of this apoprotein and its function. Yet with this great body of knowledge, there is still a great deal of consternation about the test most commonly utilized to clinically monitor the effects of vitamin K antagonists, the prothrombin time.

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Authors and Affiliations

  1. Hematology Service, Clinical Pathology Department, Clinical Center, National Institutes of Health, Building 10, Room 2C390, Bethesda, MD, 20892, USA

    Harvey R. Gralnick & Olga J. Wilson

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  1. Harvey R. Gralnick
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  2. Olga J. Wilson
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Editors and Affiliations

  1. New York University School of Medicine, New York, New York, USA

    Stanford Wessler

  2. Cornell University Medical College, New York, New York, USA

    Carl G. Becker

  3. Mt. Sinai School of Medicine of the City University of New York, New York, New York, USA

    Yale Nemerson

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Gralnick, H.R., Wilson, O.J. (1987). Cold-Promoted Activation of Factor VII and Shortening of the Prothrombin Time. In: Wessler, S., Becker, C.G., Nemerson, Y. (eds) The New Dimensions of Warfarin Prophylaxis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5985-3_9

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  • DOI: https://doi.org/10.1007/978-1-4757-5985-3_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5987-7

  • Online ISBN: 978-1-4757-5985-3

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