Warfarin and Bone: Implications for Rational Strategies to Selectively Antagonize the Action of Vitamin K in Target Tissues

  • Paul A. Price


We have recently reported that vitamin K counteracts the action of Warfarin on blood coagulation but not on the synthesis of bone Gla protein (BGP; osteocalcin) (1). The purpose of this paper is to describe the observations which led to this discovery and the implications of this discovery for Warfarin prophylaxis.


Coagulation Time Extrahepatic Tissue Blood Coagulation Factor Warfarin Plus Carboxyglutamic Acid 
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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Paul A. Price
    • 1
  1. 1.Department of Biology (B-022)University of California at San DiegoLa JollaUSA

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