The Biochemical Basis of Warfarin Therapy

  • J. W. Suttie

Abstract

The necessity of a dietary nutrient to maintain normal blood coagulation function was discovered by Dam in the late 1920’s during his efforts to demonstrate the essentiality of cholesterol in the diet of the chick. He noted a hemorrhagic condition in chicks fed lipid-free diets and demonstrated that the addition of alfalfa meal or a lipid extract of alfalfa would prevent this condition. Continued study of this response in the early 1930’s by the research groups of Dam, Almquist, and Doisy led to the isolation, characterization, and synthesis of the active compound, 2-Me-3-phytyl-l, 4-naphthoquinone (phylloquinone). These early studies also demonstrated that in addition to phylloquinone or vitamin K1 in green plants, vitamin K activity was present in many bacteria as a series of menaqui-nones, 2-Me-l, 4-naphthoquinones substituted at the 3-position with an unsaturated polyisoprenoid chain. These historical aspects of the discovery of vitamin K have been adequately reviewed.1

Keywords

Warfarin Therapy Quinone Reductase Carboxylation Reaction Epoxide Reductase Glutamyl Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • J. W. Suttie
    • 1
  1. 1.Department of BiochemistryUniversity of Wisconsin-MadisonMadisonUSA

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