Skip to main content

Abstract

Using the smallest effective dose of warfarin, clearly will diminish hemorrhage. But there are more than a dozen factors other than dose that can either favorably effect the benefit/risk ratio or tell the physician that he should or should not consider using warfarin in specific patient groups. Three of these factors, the prothrombin time, warfarin resistance, and drug-drug interactions, have already been commented upon at this symposium and so I shall discuss several other factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. S. Wessler, A Guide to Anticoagulant Therapy, American Heart Association, 1984.

    Google Scholar 

  2. S. Wessler, Is anticoagulant prophylaxis of cardiac emboli practical?, Geriatrics (in press).

    Google Scholar 

  3. J. G. Hall, R. M. Pauli, and K. M. Wilson, Maternal and fetal sequelae of anticoagulation during pregnancy. Am J Med 68:122(1980).

    Article  PubMed  CAS  Google Scholar 

  4. R. A. O’Reilly, and P. M. Aggeler, Determination of the response to oral anticoagulant drugs in man. Pharmacol Rev 22:35, 1980.

    Google Scholar 

  5. K. Fries, F. E. Konig, and T. Reich, Einfluss der Marcoumar-Therapie bei voll gestillten kindern, Schweiz Med Wochen Schr, 87:615(1957).

    CAS  Google Scholar 

  6. E. Marciniak, and J. P. Gockerman, Heparin-induced decrease in circulating antithrombin III, Lancet 2:581(1977).

    Article  PubMed  CAS  Google Scholar 

  7. S. Wessler, S. N. Gitel, H. Bank, U. Martinowitz, and R. C. Stephenson, An assay of the antithrombotic action of warfarin: its correlation with the inhibition of stasis thrombosis in rabbits, Thromb Haemost 40:486(1978).

    Google Scholar 

  8. J. G. Domenet, D. W. Evans, and H. Stephenson, Anticoagulants in congestive heart failure, Brit Med J, 2:866(1966).

    Article  PubMed  CAS  Google Scholar 

  9. W. W. Coon, and P. W. Willis III, Thromboembolic complications during anticoagulant therapy, Arch Surg 105:209(1972).

    Article  PubMed  CAS  Google Scholar 

  10. The Working Group on Hypertension in the Elderly. Statement on hypertension in the elderly, JAMA, 256:70(1986).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1987 Springer Science+Business Media New York

About this chapter

Cite this chapter

Wessler, S. (1987). Improving the Benefit/Risk Ratio. In: Wessler, S., Becker, C.G., Nemerson, Y. (eds) The New Dimensions of Warfarin Prophylaxis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5985-3_19

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-5985-3_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5987-7

  • Online ISBN: 978-1-4757-5985-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics