Warfarin Metabolism and Drug-Drug Interactions

  • Robert A. O’Reilly


Drug interactions with warfarin vary from useful to disastrous. The pharmacologic combination of warfarin and a platelet inhibitor can be clinically efficacious. Contrarily, the increasing number of drugs that interact with warfarin can potentiate its anticoagulant effect and cause life-threatening hemorrhagic events. To avoid the futility of memorizing long lists of these drugs, guidelines will be presented for the prescribing physician. These concepts are understood best after the metabolism of warfarin in man is reviewed.


Anticoagulant Therapy Short Bowel Syndrome Anticoagulant Effect Warfarin Concentration Racemic Warfarin 
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© Springer Science+Business Media New York 1987

Authors and Affiliations

  • Robert A. O’Reilly
    • 1
  1. 1.Departments of Medicine, Santa Clara Valley Medical Center, Stanford University School of MedicineUniversity of California, San FranciscoSan JoseUSA

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