Treatment of First Episode of Venous Thrombosis

  • J. Hirsh
  • M. Levine
  • R. Hull


Patients with venous thrombosis are usually treated with heparin and then with oral anticoagulants. The pattern of practice related to the continued use of oral anticoagulants after the patient with venous thromboembolism is discharged from hospital varies considerably from centre to centre. Some clinicians use no anticoagulants after the patient is discharged, while others treat the patient for up to a year.


Venous Thrombosis International Normalize Ratio Anticoagulant Therapy Oral Anticoagulant Oral Anticoagulant Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Barritt DW, Jordan SC: Anticoagulant drugs in the treatment of pulmonary embolism. Lancet 1960; 2:1309–1312.CrossRefGoogle Scholar
  2. 2.
    Coon WW, Willis PW: Recurrence of venous thromboembolism. Surgery 1973; 73:823–827PubMedGoogle Scholar
  3. 3.
    Hull R, Delmore T, Genton E, et al: Warfarin sodium versus low-dose heparin in the long-term treatment of venous thrombosis. N Engl J Med 1979; 301:855–858PubMedCrossRefGoogle Scholar
  4. 4.
    Lagerstedt CI, Olsson CT, Fagher BO, Oqvist BW, Albrechtsson U: Need for long-term anticoagulant treatment in symptomatic calf vein thrombosis. Lancet 1985; 2:515–518PubMedCrossRefGoogle Scholar
  5. 5.
    Hull R, Delmore T, Carter C, et al: Adjusted subcutaneous heparin versus warfarin sodium in the long-term treatment of venous thrombosis. N Engl J Med 1982; 306:189–194PubMedCrossRefGoogle Scholar
  6. 6.
    Hull R, Hirsh J, Jay R, et al: Different intensities of oral anticoagulant therapy in the treatment of proximal-vein thrombosis. N Engl J Med 1982; 307:1676–1681PubMedCrossRefGoogle Scholar
  7. 7.
    O’Sullivan EF: Dura;tion of anticoagulant therapy in venous thromboembolism. Med J Aust 1972; 2:1104–1107PubMedGoogle Scholar
  8. 8.
    Holmgren K, Andersson G, Fagrell B, et al: One month versus six month therapy with oral anticoagulants after symptomatic deep vein thrombosis. Acta Med Scand 1985; 218:279–284PubMedCrossRefGoogle Scholar
  9. 9.
    Jay R, Hull R, Carter C, et al: Outcome of abnormal impedance plethysmography results in patients with proximal vein thrombosis: frequency of return to normal. Thromb Res 36:259–263, 1984PubMedCrossRefGoogle Scholar
  10. 10.
    Adar R, Salzman EW: Treatment of thrombosis of veins of the lower extremities. N Engl J Med 1975; 292:348PubMedCrossRefGoogle Scholar
  11. 11.
    Kakkar Vv, Flanc C, Howe CT, et al: Natural history of post-operative deep vein thrombosis. Lancet 1969; 2:230PubMedCrossRefGoogle Scholar
  12. 12.
    Hull RD, Hirsh J, Carter CJ, et al: A randomized trial of non-invasive testing for clinically suspected deep vein thrombosis: the diagnostic efficacy of impedance plethysmography. Ann Intern Med 1985; 102:21–28PubMedCrossRefGoogle Scholar
  13. 13.
    Wheeler HB, Anderson FA, Jr.: Can noninvasive tests be used as the basis for treatment of deep vein thrombosis? In: Noninvasive Diagnostic Techniques in Vascular Disease, Chapter 58, 1982; pp. 545Google Scholar
  14. 14.
    Huisman MV, Buller HR, ten Cate JW, et al: Evaluation of serial impedance plethysmography in the diagnosis of symptomatic deep vein thrombosis (DVT). Thromb Haemostas 1985; 54:157 (Abstract)Google Scholar
  15. 15.
    Jonker JJC, de Boer AC, den Ottolander GJH: Impedance plethysmography (IPC) in the management of patients with deep vein thrombosis (DVT) at home. Thromb Haemostas 1985; 54:99 (Abstract)Google Scholar
  16. 16.
    Bentley PG, Kakkar W, Scully MF, et al: An objective study of alternative methods of heparin administration. Thromb Res 1980; 18:177PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1987

Authors and Affiliations

  • J. Hirsh
    • 1
  • M. Levine
    • 1
  • R. Hull
    • 1
  1. 1.Department of MedicineMcMaster UniversityHamiltonCanada

Personalised recommendations