Bacterial Symbionts of the Bryostatin-Producing Bryozoan Bugula Neritina
Bugula neritina (Cheilostomata, Cellularoidea) is an arborescent bryozoan with a cosmopolitan distribution in temperate marine waters. Bugula neritina is a subject of current research interest because it is the source of the bryostatins (Pettit, 1991) a family of cytotoxic macrocyclic lactones, one of which, bryostatin 1, is currently in clinical trials for treatment of cancer (Jayson et al., 1995; Philip et al., 1993; Prendiville et al., 1993). Many bryozoans produce alkaloids (Anthoni et al., 1990) presumably as a chemical defense, but B. neritina is the only bryozoan currently known to produce complex polyketides. Polyketides are compounds typically produced by actinomycetes and fungi, and in at least one case by a proteobacterium (Schupp et al., 1995).
KeywordsGamma Proteobacteria Bacterial Symbiont Xanthomonas Campestris Francisella Tularensis Acinetobacter Calcoaceticus
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