Abstract
The sustainable supply of marine-derived bioactive compounds to meet demands for pre-clinical and clinical evaluation is a major consideration in drug development strategies. It is also a concern to environmental resource managers, particularly since conservation of genetic resources may preclude harvesting as a bulk supply strategy. Our research addresses this need by focusing on in vitro production of antitumor compounds through cell culture of the source organisms. Our objectives are: to establish cultures of bioactive marine invertebrates that can be used as models to study in vitro production of antitumor compounds and the factors which control expression of their production; to provide bulk supplies of these compounds through in vitro production; and to produce new structural analogs via manipulation of culture conditions.
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Pomponi, S.A. et al. (1998). In Vitro Production of Marine-Derived Antitumor Compounds. In: Gal, Y.L., Halvorson, H.O. (eds) New Developments in Marine Biotechnology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5983-9_15
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DOI: https://doi.org/10.1007/978-1-4757-5983-9_15
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