Biocompatible Alginates for Use in Biohybrid Organs

  • Gerd Klöck
  • Patrik Gröhn
  • Christan Hasse
  • Ulrich Zimmermann


Using artificial, semi-permeable membranes, transplanted tissue can be physically isolated from the immune system of the recipient (immunoisolation). This allows, in principle, transplantation of cells of different genera, without the need for pharmacological immunosuppression (Clayton et al., 1993; Colton, 1995; Lanza & Chick, 1997). In the past, a whole range of different concepts have been employed to achieve this goal (see Clayton et al., 1993; Colton, 1995; Geisen et al., 1990; Lanza & Chick, 1997). It is now generally accepted that micocapsules composed of natuaral polysacccharides, especially of alginates, are the material of choice (Clayton et al., 1993; Geisen et al., 1990; Lanza & Chick, 1997; Smidsrod & Skjak-Braerk, 1990).


Parathyroid Tissue Hydrogel Bead Guluronic Acid Murine Splenocytes Free Flow Electrophoresis 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Gerd Klöck
    • 1
  • Patrik Gröhn
    • 1
  • Christan Hasse
    • 2
  • Ulrich Zimmermann
    • 1
  1. 1.Department of BiotechnologyUniversity of WürzburgWürzburgGermany
  2. 2.Department of SurgeryUniversity of MarburgMarburgGermany

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