Evidence for Cholecystokinin Receptor and Intracellular Signal Transduction in Relation to Amylase Secretion

  • Hiro-o Kamiya
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 236)


Cholecystokinin (CCK) was first isolated from porcine intestine as a polypeptide with 33 amino acid residues (CCK-33) (1). Studies using radioimmunoassay techniques in combination with column chromatography have shown that CCK is present in different molecular forms in the intestine (2, 3) and the brain (3 – 5). The major form of CCK, CCK-8, carries all the known biological activities of CCK-33 and is considered as a putative neurotransmitter or neuromodulator in the central nervous system. The exact role of CCK-8 in the brain is unknown, but has been suggested to be modulation of activity of catecholaminergic neurons in the mesolimbic system (6 – 8).


Cerebral Cortex Pancreatic Acinar Cell Scatchard Analysis Pancreatic Acinus Amylase Secretion 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Hiro-o Kamiya
    • 1
  1. 1.Department of Pharmacology, Faculty of Pharmaceutical SciencesFukuoka UniversityFukuokaJapan

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