Studies of Multiple Morphine and Enkephalin Receptors: Evidence for Mu1 Receptors

  • Gavril W. Pasternak
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 236)


The concept of receptors plays in integral role in pharmacology. Many drugs act through interactions with specific binding sites and dissociate unchanged, unlike enzymes which modify subtrates. The realization that subtypes of receptors for a ligand may exist has opened a number of possibilities in drug development and remains important. In the past, the classification of receptor subtypes rested heavily upon either classical bioassays or in vivo studies. More recently, the availability of binding assays has permitted a more molecular approach to this question. Both approaches have their advantages and disadvantages. These are important issues since the development of highly selective drugs is often based upon the identification of subtypes of receptors with highly selective functions.


Opioid Peptide Opiate Receptor Morphine Analgesia Delta Receptor High Affinity Component 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Gavril W. Pasternak
    • 1
    • 2
  1. 1.The Cotzias Laboratory of Neuro-OncologyMemorial Sloan-Kettering Cancer CenterNew YorkUSA
  2. 2.Departments of Neurology and PharmacologyCornell U. Medical CollegeNew YorkUSA

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