Histaminergic Neuron System and its Function

  • H. Wada. A. Yamatodani
  • N. Inagaki
  • N. Itowi
  • N. P. Wang
  • H. Fukui
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 236)


Histamine as a neurotransmitter or a neuroregulator in the mammalian brain has been postulated on the basis of biochemical, pharmacological and neurophysiological studies (1–5). We have demonstrated the histaminergic neuron system in rat brain immunocytochemically (6,7) using antibody raised against histidine decarboxylase (HDC), the sole enzyme responsible for histamine synthesis, as a marker (8). Histamine neurons were found to be concentrated in the magnocellular nuclei in the posterior hypothalamic area of rat brain, such as the tuberai magnocellular nucleus, caudal magnocellular nucleus and postmammillary caudal magnocellular nucleus, while their fibers were found in many areas, such as the hypothalamus, cerebral cortex, olfactory nuclei, basal ganglia, hippocampus, septum, cerebellum, amygdaloid complex, nucleus of the diagonal band, bed nucleus of the stria terminalis, central gray, auditory system, medial vestibular nucleus, facial nucleus, dorsal parabrachial nucleus, and nucleus of the solitary tract (7). Similar results were observed using antibodies against histamine itself (9–11).


Motion Sickness Medial Forebrain Bundle Histidine Decarboxylase Medial Vestibular Nucleus Amygdaloid Complex 
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Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • H. Wada. A. Yamatodani
    • 1
  • N. Inagaki
    • 1
  • N. Itowi
    • 1
  • N. P. Wang
    • 1
  • H. Fukui
    • 1
  1. 1.Department of Pharmacology IIOsaka University Medical SchoolKita-ku, Osaka 530Japan

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