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Correlation between the Binding Parameters of Muscarinic Agonists and thier Inhibition of Adenylate Cyclase Activity

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Neuroreceptors and Signal Transduction

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 236))

Abstract

Muscarinic receptors are widely distributed throughout the body and play a key role in numerous vital functions.1 Activation of muscarinic receptors decreases the rate and force of contraction of the heart, relaxes peripheral blood vessels, constricts the airways of the lung, increases the secretions or motility of various organs of the gastrointestinal tract, increases the secretions of the lacrimal, salivary and sweat glands, and constricts the iris sphincter and ciliary muscles of the eye. Muscarinic receptors also participate in important functions within the brain including learning, memory and the control of posture.1

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Authors and Affiliations

  1. Department of Pharmacology, College of Medicine, University of California, Irvine, Irvine, CA, 92717, USA

    Frederick J. Ehlert

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  1. Frederick J. Ehlert
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Editors and Affiliations

  1. Hiroshima University, Hiroshima, Japan

    Shozo Kito  & Tomio Segawa  & 

  2. Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kinya Kuriyama

  3. Osaka University, Osaka, Japan

    Masaya Tohyama

  4. University of California, Los Angeles, Los Angeles, California, USA

    Richard W. Olsen

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© 1988 Springer Science+Business Media New York

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Ehlert, F.J. (1988). Correlation between the Binding Parameters of Muscarinic Agonists and thier Inhibition of Adenylate Cyclase Activity. In: Kito, S., Segawa, T., Kuriyama, K., Tohyama, M., Olsen, R.W. (eds) Neuroreceptors and Signal Transduction. Advances in Experimental Medicine and Biology, vol 236. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5971-6_21

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  • DOI: https://doi.org/10.1007/978-1-4757-5971-6_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5973-0

  • Online ISBN: 978-1-4757-5971-6

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