Abstract
The presence of two subtypes in muscarinic acetylcholine receptors (m-AChR) was well established. One is the M1 subtype, neuronal m-AChR, and the other is M2 subtype, peripheral m-AChR. Now, the presence of many more subtypes is suggested by the evidences from pharmacology and gene technology.
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S. Uchida, K. Matsumoto, A. Mizushima, T. Osugi, H. Higuchi and H. Yoshida, Effect of guanine nucleotide and sulfhydryl reagent on subpopulations of muscarinic acetylcholine receptors in mammalian hearts., Eur. J. Pharmacol. 100: 291 (1984).
N. J. M. Birdsall, A. S. V. Burgen and E. C. Hulme, The binding of agonists to brain muscarinic receptors., Mol. Pharmacol. 14: 723 (1978)
S. Uchida, K. Matsumoto, K. Takeyasu, H. Higuchi and H. Yoshida, Molecular mechanism of the effects of guanine nucleotide and sulfhydryl reagent on muscarinic receptors in smooth muscles studied by radiation inactivation., Life Sci. 31: 201 (1982)
A. Mizushima, S. Uchida, K. Matsumoto, T. Osugi, T. Kagiya, X.-M. Zhou, H. Higuci and H. Yoshida, Multiple agonists binding sites of muscarinic acetylcholine receptors and their relation to the negative inotropic action of agonists in guinea pig heart, Eur. J. Pharmacol. 119: 177 (1985)
A. Mizushima, S. Uchida, X.-M. Zhou, T. Kagiya and H. Yoshida, Czrdiac M2 receptors consist of two different types, both regulated by GTP, Eur. J. Pharmacol. 135: 403 (1987)
T. Kubo, A. Meda, K. Sugimoto et al., Primary structure of porcine muscarinic receptor deduced from the cDNA sequence, FEBS letters, 209: 367 (1986)
T. I. Bonner, N. J. Buckley, A. C. Young and M. R. Brann, Identification of a family of muscarinic acetylcholine receptor genes, Sci. 237: 527 (1987)
R. Hammer, C. P.Berrie, N. J. M. Birdsall and E. C. Burgen, Pirenzepine distinguishes between different subclasses of muscarinic receptors, Nature, 283: 90 (1980)
R. Hammer, E. Gialdo, G. B. Monferini and H. Ladinsky, Binding profile of a novel cardioselective muscarinic receptor antagonist, AF-DX 116 to membranes of peripheral tissues and brain in the rat, Life Sci. 38: 1653 (1986)
R. F. Furchgott and P. Bursztyn, Comparison of dissociation constants and of relative efficacies of selected agonists acting on parasympathetic receptors, Ann. N. Y. Acad. Sci. 144: 882 (1967)
T. Osugi, S. Uchida T. Imaizumi and H. Yoshida, Bradykinin-induced intracellular Ca4+ elevation in neuroblastoma x glioma hybrid NG108–15 cells; relationship to the action of inositol phospholipids metabolites, Brain Res. 379: 84 (1986)
A. Yatani, J. Codina, A. M. Brown and L. Birnbaumer, Direct activation of mammalian atrial muscarinic potassium channels by GTP regulatory protein Gk, Science 235: 207 (1987)
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© 1988 Springer Science+Business Media New York
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Uchida, S., Mizushima, A., Zhou, XM., Yoshida, H. (1988). Agonist Bindings and their Relationship to Receptor Responses in Heart Muscarinic Receptors. In: Kito, S., Segawa, T., Kuriyama, K., Tohyama, M., Olsen, R.W. (eds) Neuroreceptors and Signal Transduction. Advances in Experimental Medicine and Biology, vol 236. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5971-6_20
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DOI: https://doi.org/10.1007/978-1-4757-5971-6_20
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