Biosynthesis of Glycosaminoglycans and Proteoglycans

  • Nancy B. Schwartz
  • Neil R. Smalheiser


The class of polysaccharides known as glycosaminoglycans consists of repeated disaccharides, usually containing a sulfated hexosamine and uronic acid. As abundant constituents of extracellular matrices, most work on glycosaminoglycans has focused on their roles in cartilage, bone, and synovial fluid, where they are thought to be important for tissue turgor and hydration, ion binding and buffering, and tensile strength and resiliency. Early interest in the biosynthesis of glycosaminoglycans was generated by the discovery of lysosomal storage diseases and disorders of connective tissue metabolism such as arthritis.


Hyaluronic Acid Heparan Sulfate Chondroitin Sulfate Core Protein Sulfate Proteoglycan 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Nancy B. Schwartz
    • 1
  • Neil R. Smalheiser
    • 2
  1. 1.Departments of Pediatrics and Biochemistry and Molecular Biology, and the Kennedy Mental Retardation Research CenterUniversity of ChicagoChicagoUSA
  2. 2.Department of Pediatrics and the Kennedy Mental Retardation Research CenterUniversity of ChicagoChicagoUSA

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