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Biosynthesis of Glycoproteins

  • Chapter
Neurobiology of Glycoconjugates

Abstract

Since membrane glycoproteins have been implicated in many neurobiological processes and functions (see Chapters 7, 8, and 11), the mechanisms and regulation of biosynthesis of the oligosaccharide units have been of great interest to cell and neurobiologists during the past 20 years. Much of this research activity has focused on the structure, biosynthesis, and function of N-linked oligosaccharides because the majority of the carbohydrate chains attached to membrane glycoproteins in nervous tissue are attached via N-glycosidic bonds (Krusius and Finne, 1977). For further discussion of the structural details of carbohydrate units of brain glycoproteins, see Chapter 3.

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  1. Department of Biochemistry, University of Kentucky College of Medicine, A. B. Chandler Medical Center, Lexington, Kentucky, 40536, USA

    Charles J. Waechter

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  1. Charles J. Waechter
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  1. Department of Pharmacology, New York University Medical Center, 10016, New York, New York, USA

    Richard U. Margolis

  2. Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, 11203, Brooklyn, New York, USA

    Renée K. Margolis

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Waechter, C.J. (1989). Biosynthesis of Glycoproteins. In: Margolis, R.U., Margolis, R.K. (eds) Neurobiology of Glycoconjugates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5955-6_4

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