Hyaluronate and Hyaluronate-Binding Proteins of Brain

  • Bryan P. Toole


Migratory and proliferating cells in the embryo are usually surrounded by hyaluronateenriched extracellular matrices (reviewed in Toole, 1981). For example, hyaluronate accumulates in the pathways of migration of corneal mesenchyme (Toole and Trelstad, 1971), neural crest cells (Pratt et al.,1975; Derby, 1978; Pintar, 1978), endocardial cushion cells (Markwald et al., 1978), and sclerotomal mesenchyme (Kvist and Finnegan, 1970; Toole, 1972; Solursh et al.,1979). Frequently, subsequent differentiation is accompanied by decreases in levels of hyaluronate in these tissues.


Hyaluronic Acid Neural Crest Cell Link Protein Cartilage Proteoglycan Hyaluronic Acid Binding Protein 
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© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Bryan P. Toole
    • 1
  1. 1.Department of Anatomy and Cellular BiologyTufts University Health Sciences CenterBostonUSA

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