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Hyaluronate and Hyaluronate-Binding Proteins of Brain

  • Chapter
Neurobiology of Glycoconjugates

Abstract

Migratory and proliferating cells in the embryo are usually surrounded by hyaluronateenriched extracellular matrices (reviewed in Toole, 1981). For example, hyaluronate accumulates in the pathways of migration of corneal mesenchyme (Toole and Trelstad, 1971), neural crest cells (Pratt et al.,1975; Derby, 1978; Pintar, 1978), endocardial cushion cells (Markwald et al., 1978), and sclerotomal mesenchyme (Kvist and Finnegan, 1970; Toole, 1972; Solursh et al.,1979). Frequently, subsequent differentiation is accompanied by decreases in levels of hyaluronate in these tissues.

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Authors and Affiliations

  1. Department of Anatomy and Cellular Biology, Tufts University Health Sciences Center, Boston, Massachusetts, 02111, USA

    Bryan P. Toole

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  1. Department of Pharmacology, New York University Medical Center, 10016, New York, New York, USA

    Richard U. Margolis

  2. Department of Pharmacology, State University of New York, Health Science Center at Brooklyn, 11203, Brooklyn, New York, USA

    Renée K. Margolis

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Toole, B.P. (1989). Hyaluronate and Hyaluronate-Binding Proteins of Brain. In: Margolis, R.U., Margolis, R.K. (eds) Neurobiology of Glycoconjugates. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5955-6_14

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