Synaptic Vesicle Glycoproteins and Proteoglycans

  • Steven S. Carlson


Immunological markers specific for synaptic vesicles have been helpful in studying synapse regeneration (Glicksman and Sanes, 1983), development (Chun and Shatz, 1983), and tracing membrane traffic in the nerve terminal (von Wedel et al., 1981). Vesicle-specific antibodies have also identified a number of vesicle proteins. This chapter deals with four antigenic integral membrane proteins of the synaptic vesicle. These proteins, identified with monoclonal antibodies, are the best characterized vesicle membrane components. Three of these proteins are probably present in all vesicles of the regulated pathway of neuroendocrine cells. This includes both dense-core vesicles and small, clear synaptic vesicles. The cDNA for one of these proteins, p38, has been cloned and sequenced. The fourth protein is an integral membrane proteoglycan (SVPG) which has been found in some synaptic vesicles, but could have a wider distribution. Interestingly, this proteoglycan shares a unique antigenic site with a putative nerve terminal anchorage protein, TAP-1.


Synaptic Vesicle Secretory Granule Integral Membrane Protein Antigenic Site Electric Organ 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Steven S. Carlson
    • 1
  1. 1.Department of Physiology and BiophysicsUniversity of WashingtonSeattleUSA

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