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The Endoplasmic Reticulum Stress Response in Health and Disease

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Book cover Molecular Mechanisms of Programmed Cell Death

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Abstract

The ER stress response is a signaling pathway that transmits information about the homeostasis of the ER lumen (or its disruption) to the nucleus and cytoplasm. Metazoan cells can respond to ER stress by upregulating protein folding, export and degradation machinery, by downregulating global translation, and by apoptosis. The ER stress response has been well characterized in S. cerevisiae, but the mammalian ER stress pathways are significantly more complex and only partially understood. Here we review the major components of both the yeast and mammalian ER stress response pathways and highlight their role in both normal cellular physiology and selected pathological conditions.

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Authors and Affiliations

  1. Department of Cell Biology, Harvard Medical School Boston, MA, 02115, USA

    Junying Yuan

Authors
  1. Michael Boyce
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  2. Junying Yuan
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Editor information

Editors and Affiliations

  1. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA

    Yufang Shi

  2. National Institutes of Health, Research Triangle Park, North Carolina, USA

    John A. Cidlowski

  3. American Red Cross, Rockville, Maryland, USA

    David Scott

  4. Chinese Academy of Sciences, Shanghai, China

    Jia-Rui Wu

  5. National Institutes of Health, Bethesda, Maryland, USA

    Yun-Bo Shi

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© 2003 Springer Science+Business Media New York

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Boyce, M., Yuan, J. (2003). The Endoplasmic Reticulum Stress Response in Health and Disease. In: Shi, Y., Cidlowski, J.A., Scott, D., Wu, JR., Shi, YB. (eds) Molecular Mechanisms of Programmed Cell Death. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5890-0_3

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  • DOI: https://doi.org/10.1007/978-1-4757-5890-0_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3404-8

  • Online ISBN: 978-1-4757-5890-0

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