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Molecular Mechanisms of Programmed Cell Death pp 185–193Cite as

Ubiquitin and Intracellular Aggregation

A Common Pathway of Neurodegeneration in Chronic Dementia?

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Abstract

The ubiquitin-proteasome system (UPS) is involved in many biological pathways via the degradation of short-lived and regulatory proteins important in cellular processes. Moreover, in the most of the chronic human neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD), protein aggregation co-localized with ubiquitin is a common feature and may be caused by the abrogation of UPS. Parkin gene isolated from autosomal recessive-juvenile parkinsonism (AR-JP) is ubiquitin-protein ligase (E3) and many mutations of parkin in familial PD disrupted the ubiquitin-protein ligase activity to eventually accumulate its substrates in intracellular aggresome (Lewy body). Pathogenic proteins of AD, including presenilin and Amyloid-b Precursor Protein (APP), are the substrates of UPS and the mutations related with AD pathogenesis give resistance to their degradation by proteasome. Therefore, UPS is the important target of therapeutic trial for neurodegenerative disorders.

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Authors and Affiliations

  1. Department of Life Science, Kwangju Institute of Science and Technology, 1 Oryong-dong, Puk-gu, Gwangju, 500-712, Korea

    Yong-Keun Jung

Authors
  1. Sungmin Song
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  2. Yong-Keun Jung
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Correspondence to Yong-Keun Jung .

Editor information

Editors and Affiliations

  1. Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey, USA

    Yufang Shi

  2. National Institutes of Health, Research Triangle Park, North Carolina, USA

    John A. Cidlowski

  3. American Red Cross, Rockville, Maryland, USA

    David Scott

  4. Chinese Academy of Sciences, Shanghai, China

    Jia-Rui Wu

  5. National Institutes of Health, Bethesda, Maryland, USA

    Yun-Bo Shi

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Song, S., Jung, YK. (2003). Ubiquitin and Intracellular Aggregation. In: Shi, Y., Cidlowski, J.A., Scott, D., Wu, JR., Shi, YB. (eds) Molecular Mechanisms of Programmed Cell Death. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5890-0_16

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  • DOI: https://doi.org/10.1007/978-1-4757-5890-0_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4419-3404-8

  • Online ISBN: 978-1-4757-5890-0

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