Basic Fibroblast Growth Factor Affects the Survival and Development of Mesencephalic Neurons in Culture

  • Giovanna Ferrari
  • Maria-Cristina Minozzi
  • Gino Toffano
  • Alberta Leon
  • Stephen D. Skaper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)

Abstract

The survival and growth of neurons within the CNS is thought to be regulated by the availability of appropriate neuronotrophic factors. Compelling evidence for this idea derives from the recent findings that Nerve Growth Factor (NGF), the classical trophic factor for neural crest-derived peripheral neurons (Levi-Montalcini, 1966; Greene and Shooter, 1980; Thoenen and Barde, 1980) is also present within the CNS, where it has been proposed to act as a neuronotrophic factor for developing and lesioned adult cholinergic neurons in the basal forebrain (Gnahn et al., 1983; Hefti, 1986; Korsching, 1986; Kromer, 1987; Williams et al., 1986). These observations have encouraged the view that neuronotrophic factors in general may play an important role, not only during development but also in the adult, in particular following brain injury. At present NGF appears to address specific and limited populations of neurons. It is thus reasonable to believe that additional trophic factors exist for yet other types of neurons.

Keywords

Amyotrophic Lateral Sclerosis Nerve Growth Factor Basic Fibroblast Growth Factor GABAergic Neuron Gaba Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Giovanna Ferrari
    • 1
  • Maria-Cristina Minozzi
    • 1
  • Gino Toffano
    • 1
  • Alberta Leon
    • 1
  • Stephen D. Skaper
    • 1
  1. 1.Fidia Research LaboratoriesAbano TermeItaly

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