Abstract
The structural basis of the cellular disturbance in Alzheimer’s disease (AD) may involve the cytoskeleton. One of the major constituents of the cytoskeleton is the microtubule network. This is composed primarily of tubulin which has a molecular weight of 55 kd and assembles, under certain conditions, to form the microtubules (Cleveland et al., 1977). Other microtubular components include the microtubule associated proteins (MAPS), MAP I and MAP II, and Tau proteins, which co-purify with MAPs. “Tau” represents a class of several proteins which will be referred to collectively as Tau protein.
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Sternberg, H., Mesco, G., Cole, G., Timiras, P.S. (1990). Tau Protein: Its Presence and Metabolism in Human Neuroblastoma Cells. In: Lauder, J.M., Privat, A., Giacobini, E., Timiras, P.S., Vernadakis, A. (eds) Molecular Aspects of Development and Aging of the Nervous System. Advances in Experimental Medicine and Biology, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5876-4_27
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