Ontogeny of the Glucocorticoid Receptor in the Rat Brain

  • M. N. Alexis
  • E. Kitraki
  • K. Spanou
  • F. Stylianopoulou
  • C. E. Sekeris
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)


Glucocorticoids regulate the stress response via a negative feedback control on the brain-pituitary-adrenal axis1,2. In addition, in the brain glucocorticoids modulate the action of several monoamine, peptide and aminoacid neurotransmitters2. Glucocorticoid effects on the brain are likely to occur via receptor-mediated regulation of the rate of transcription of a set of genes2,3,4. In this light, it is interesting to study in parallel the ontogeny of glucocorticoid receptor and glucocorticoid regulation of glycerol-3-phosphate dehydrogenase (GPDH) activity3,4 in order to follow their coupling during brain development.


Glucocorticoid Receptor Plasma Corticosterone GPDH Activity Glucocorticoid Effect Nuclear Uptake 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • M. N. Alexis
    • 1
  • E. Kitraki
    • 2
  • K. Spanou
    • 1
  • F. Stylianopoulou
    • 2
  • C. E. Sekeris
    • 1
  1. 1.The National Hellenic Research FoundationAthensGreece
  2. 2.School Health SciencesUniversity of AthensAthensGreece

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