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Neurotransmitter Activation of Second Messenger Pathways for the Control of Growth Cone Behaviors

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Molecular Aspects of Development and Aging of the Nervous System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 265))

Abstract

The neuronal growth cone is now well recognized as one of the primary organelles responsible for the generation, alteration, and regeneration of neuronal form and connectivity (see review by Kater and Letourneau, 1985). The term neuronal growth cone was given by Ramon y Cajal (1890), to define the broad, flattened, lamellapodia and numerous filopodia that characterize the tip of a growing neunte. The growth cone is a highly dynamic structure; the lamellapodium and filopodia continuously move as the growth cone “explores” its environment. Discriminatory behavior is characteristic of motile growth cones; frequently the growth cone turns, branches, or even stops, apparently in response to invisible cues. Once growth cone motility, and hence neurite elongation ceases growth cone morphology also changes; the growth cone rounds up as the lamellapodium and filopodia are withdrawn.

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Author information

Authors and Affiliations

  1. Department of Anatomy and Neurobiology Program in Neuronal Growth and Development, Colorado State University, Fort Collins, CO, 80523, USA

    S. B. Kater & L. R. Mills

Authors
  1. S. B. Kater
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  2. L. R. Mills
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Editor information

Editors and Affiliations

  1. The University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA

    Jean M. Lauder

  2. Institute of Biology, INSERM, Montpellier, France

    Alain Privat

  3. Southern Illinois University School of Medicine, Springfield, Illinois, USA

    Ezio Giacobini

  4. University of California, Berkeley, California, USA

    Paola S. Timiras

  5. University of Colorado School of Medicine, Denver, Colorado, USA

    Antonia Vernadakis

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© 1990 Springer Science+Business Media New York

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Kater, S.B., Mills, L.R. (1990). Neurotransmitter Activation of Second Messenger Pathways for the Control of Growth Cone Behaviors. In: Lauder, J.M., Privat, A., Giacobini, E., Timiras, P.S., Vernadakis, A. (eds) Molecular Aspects of Development and Aging of the Nervous System. Advances in Experimental Medicine and Biology, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5876-4_21

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  • DOI: https://doi.org/10.1007/978-1-4757-5876-4_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5878-8

  • Online ISBN: 978-1-4757-5876-4

  • eBook Packages: Springer Book Archive

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