Structure and Function of the Neural Cell Adhesion Molecules NCAM and L1

  • Ole Nybroe
  • Elisabeth Bock
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)


During development of the nervous system, several morphogenetic processes act together to establish its orderly structure by generating specific nerve connections. The steps involved in neural pattern formation include cell differentiation, cell migration, axonal outgrowth, target recognition and synapse formation. Earlier, these processes were only characterized at the morphological level although it was obvious that adhesive interactions between cell surfaces and the extracellular milieu were of central importance. Several systems mediating cell-cell or cell-substratum adhesion have now been identified on the surface of neural cells and described at the molecular level (Jessell, 1988; Rutishȧuser and Jessell, 1988).


Cytoplasmic Domain Neural Cell Adhesion Molecule Adhesion System Polysialic Acid Internal Granule Cell Layer 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Ole Nybroe
    • 1
  • Elisabeth Bock
    • 1
  1. 1.Research Center for Medical Biotechnology The Protein LaboratoryUniversity of CopenhagenCopenhagen NDenmark

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