Abstract
The differentiation of neuronal cells involves the synthesis of cell-specific macromolecules, as well as the assembly of the latter into supramolecular entities responsible for complex patterns of cell organization. For example, axons are distinguished from dendrites by the presence or absence of ribosomes and by the specific distribution of molecules such as cytoskeletal proteins, a-bungarotoxin receptors and GAP-43, among others (Banker and Waxman, 1988; Goslin et al., 1988). Asymmetries in molecular distribution also occur within individual neuronal processes, as illustrated by the concentration of voltage-sensitive sodium channels at the nodes of Ranvier (Ritchie, 1977; Angelides, et al., 1988). Although all neurons seem to share a similar polarized pattern of organization, different types of neurons can be distinguished by unique variations of this common pattern. Cell-specific morphology and branching patterns of axons and dendrites provide clear examples of this type of diversity (i.e., Wuerker and Kirkpatrick, 1972; Peters et al., 1976; Bartlett and Banker, 1984).
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References
Adler, R., J. D. Lindsey, and C. L. Elsner. 1984. Expression of cone-like properties by chick embryo neural retinal cells in glial-free monolayer cultures. J Cell Biol. 99: 1173 - 1178.
Adler, R. 1986. Developmental predetermination of the structural and molecular polarization of photoreceptor cells. Dev. Biol. 117:520-527.
Adler, R. 1987. The differentiation of retinal photoreceptors and neurons in vitro. In: Progress in Retinal Research. Vol. 6. N. Osborne and G. Chader, editors. Pergamon Press, London. 1 - 27.
Almers, W. and C. Stirling. 1984. Distribution of transport proteins over animal cell membranes. J. Membrane Biol. 77:169-186.
Angelides, K. J., L. W. Elmer, D. Loftus and E. Elson. 1988. Distribution and lateral mobility of voltage-dependent sodium channels in neurons. J. Cell Biol. 106:1911-1925.
Axelrod, D. 1983. Lateral motion of membrane proteins and biological function. J. Memb. Biol. 75:1-10.
Banker, G. A., and A. B. Waxman. 1988. Hippocampal neurons generate natural shapes in cell culture. In Intrinsic Determinants of Neuronal Form and Function. R. J. Lasek and M. M. Black, editors. Alan R. Liss, Inc., New York, pp. 61 - 82.
Bartlett, W. P., Banker, G. A. 1984. An electron microscopic study of the development of axons and dendrites by hippocampal neurons in culture. I. Cells which develop without intercellular contacts. J. Neurosci. 4(8):1944-1953.
Besharse J. C. 1986. Photosensitive membrane turover: differentiated domains and cell-cell interaction. In The Retina: A Model for Cell Biology Studies, Part I, R. Adler and D. Farber, editors. Academic Press, New York, 297 - 339.
Bok D. 1985. Retinal photoreceptor-pigment epithelial interactions. Friedenwald Lecture. Invest. Ophth. and Vis. Sci. 26:1659-1694.
Burnside, B., and A. Dearry. 1986. Cell motility in the retina. In The Retina: A Model for Cell Biology Studies. R. Adler and D. Farber, editors. Academic Press, Orlando, 152 - 206.
Dichter, M. A. 1978. Rat cortical neurons in cell culture: Culture methods, cell morphology, electrophysiology, and synapse formation. Brain Res. 149: 279 - 293.
Fischbach, G. D. 1970. Synaptic potentials recorded in cell cultures of nerve and muscle. Science 169: 1331 - 1333.
Goslin, V., D. J. Schreyer, J. H. P. Skene, and G. Banker. 1988. Development of neuronal polarity: GAP-43 distinguishes axonal from dendritic growth cones. Nature 336: 672 - 674.
Grun, G. 1982. The development of the vertebrate retina: a comparative survey. Adv. Anat. Embryol. Cell Biol. 78:1-85.
Madreperla, S. A., and R. Adler. 1989. Opposing microtubule-and actin-dependent forces in the development and maintenance of structural polarity in retinal photoreceptors. Dev. Biol. 131:149160.
Madreperla, S. A., M. Edidin and R. Adler (1989a) Role of the cytoskeleton in the polarized distribution of the Na+,K+-ATPase in isolated photoreceptors. J. Cell Biol. 107:783a.
Madreperla, S. A., M. Edidin and R. Adler (1989b) Na+,K+-ATPase in retinal photoreceptors: a role of cytoskeletal attachments. Submitted.
McGrail, K. M., and K. J. Sweadner. 1986. Immunofluorescent localization of two different Na,K-ATPases in the rat retina and in identified dissociated retinal cells. J. Neurosci. 6(5): 12721283.
Nelson, W. J., and P. J. Veshnock. 1986. Dynamics of membrane-skeleton (fodrin) organization during development of polarity in Madin-Darby canine kidney epithelial cells. J. Cell Biol. 103:1751-1765.
Papermaster, D. S., B. G. Schneider, D. Defoe, and J. C. Besharse. 1986. Biosynthesis and vectorial transport of opsin on vesicles in retinal rod photoreceptors. J. Histochem. Cytochem. 34:5-16.
Peters, A., Palay, S. L. Webster, H. 1976. The fine structure of the nervous system. In: The neurons and the Supporting Cells. Philadelphia: W. B. Saunders. 1 - 406.
Ritchie, J. M., Rogart, R. B. 1977. Density of sodium channels in mammalian myelinated nerve fibers and nature of the axonal membrane under the myelin sheath. Proc. Natl. Acad. Sci. USA 74(1):211-5.
Scott, B. E. Engelbert, V. E., Fisher, K. C. 1969. Morphological and electrophysiological characteristics of dissociated chick embryonic spinal ganglion cells in culture. Exp. Neurol. 23: 230 - 248.
Siegel G. J., S. A. Ernst, Lin, and T. J. Desmond. 1988. Heterogeneity of the a+-catalytic subunit in mouse brain Na+,K+-ATPase. Trans. Am. Soc. Neurochem. 19: 252.
Solomon, F., Zurn, A. 1981. The cytoskeleton and specification of neuronal morphology. Neurosci. Res. Prog. Bull. 19(1):100-135.
Stirling, C. E., and P. V. Sarthy. 1985. Localization of the Na-K pump in turtle retina. J. Neurocytol. 14:33-47.
Waxman, S. G. 1986. The astrocyte as a component of the mode of Ranvier. Trends in Neurosci., 9: 250 - 253.
Wolf, D. E. 1987. Diffusion and the control of membrane regionalization. Ann. NY Acad. Aci. 247 - 261.
Wuerker, R. B., Kirkpatrick, J. B. 1972. Neuronal microtubules, neurofilaments, and microfilaments. Int. Rev. Cytol. 33:45-75.
Yazulla, S., and K. M. Studholme. 1987. Ultracytochemical distribution of ouabain-sensitive, K+-dependent, p-nitrophenylphosphatase in the synaptic layers of goldfish retina. J. Comp. Neurol. 261(1):74-84.
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Adler, R., Madreperla, S.A. (1990). Structural and Molecular Polarity in Retinal Photoreceptor Neurons: Roles for the Cytoskeleton. In: Lauder, J.M., Privat, A., Giacobini, E., Timiras, P.S., Vernadakis, A. (eds) Molecular Aspects of Development and Aging of the Nervous System. Advances in Experimental Medicine and Biology, vol 265. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5876-4_14
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DOI: https://doi.org/10.1007/978-1-4757-5876-4_14
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