A Role of Ras Oncogenes in Carcinogenesis and Differentiation

  • Demetrios A. Spandidos
  • Margaret L. M. Anderson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)


As we learn more about the process of carcinogenesis it is becoming clear that several oncogenes are involved in growth and differentiation of cells. There is also growing evidence for a role of proto-oncogene products in differentiation for example in the neuronal and hemopoietic lineages (for a review see ref.l). Proliferation and differentiation appear to be interdependent processes, in that a cycle of cell division often seems to be a prerequisite for differentiation. Further growth factors are frequently also differentiation factors.


Nerve Growth Factor Anchorage Independence Erythroid Precursor Cell Pheochromocytoma Cell Line PC12 Chinese Hamster Lung Cell 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Demetrios A. Spandidos
    • 1
    • 2
  • Margaret L. M. Anderson
    • 3
  1. 1.The Beatson Institute for Cancer ResearchBearsden, GlasgowScotland, UK
  2. 2.Biological Research CenterThe National Hellenic Research FoundationAthensGreece
  3. 3.Department of BiochemistryUniversity of GlasgowGlasgowScotland, UK

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