Localization of the Normal Cellular SRC Protein to the Growth Cone of Differentiating Neurons in Brain and Retina

  • Patricia F. Maness
  • Carol G. Shores
  • Michael Ignelzi
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 265)


The protooncogene c-src is implicated in the development of the vertebrate nervous system. Its product pp60c-src is a tyrosine-specific protein kinase that is expressed in two phases of neural development. An activated form of the pp60c-src is highly enriched in the membrane of nerve growth cones and in the proximal neuritic shaft of differentiating neurons, as shown in brain and retina. A possible role for pp60c-src in neuronal process extension is suggested that may involve cell-substratum adhesion or motility.


Chick Embryo Growth Cone Optic Tectum Retinal Neuron Neural Retina 
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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Patricia F. Maness
    • 1
  • Carol G. Shores
    • 1
  • Michael Ignelzi
    • 1
  1. 1.Department of BiochemistryUniversity of North Carolina School of MedicineChapel HillUSA

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