A Monoclonal Antibody to an Internal Molecule Differentiates Three Electrically Coupled Leech Neurons

  • Birgit Zipser


About half a decade ago, neurobiologists began to search for molecules involved in neuron-to-neuron recognition using monoclonal antibodies. The advent of monoclonal antibodies made it possible to immunize mice with the complex mixture of antigens present in whole brain tissue and to make specific antibody probes to single molecules. Generating antibodies has been relatively easy. The challenge has been to identify those antibodies that bind to candidate molecules playing a role in specifying synaptic connectivity. The trend has been to judge the likelihood of an antigen specifying neuronal connectivity by its distribution in organized brain tissue. This strategy is based on the assumption that neuronal connectivity molecules differ in kind or quantity from cell to cell.


Cell Body Nerve Cord Fiber Tract Neuronal Cell Body Lucifer Yellow 
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Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Birgit Zipser
    • 1
  1. 1.Cold Spring Harbor LaboratoryCold Spring HarborUSA

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