Are Skeletal Motoneurons in Arthropods Peptidergic?

  • Michael O’Shea


There is growing evidence for widespread involvement of peptides in the control of muscle performance in the invertebrates (O’Shea and Schaffer, 1984). In this chapter, I will consider the role of neuropeptides as possible muscle effectors in arthropods.


Extensor Muscle Neuromuscular Transmission Inhibitory Motoneuron Excitatory Motoneuron SETi Stimulation 
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  1. Adams, M. E., and O’Shea, M., 1983, Peptide cotransmitter at a neuromuscular junction, Science 221:286–289.PubMedCrossRefGoogle Scholar
  2. Bishop, C. A., and O’Shea, M., 1982, Neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH): Immunological mapping of neurons in the central nervous system of the cockroach, J. Comp. Neurol. 207:223–238.PubMedCrossRefGoogle Scholar
  3. Bishop, C. A., O’Shea, M., and Miller, R. J., 1981, Neuropeptide proctolin (H-Arg-Tyr-Leu-Pro-Thr- OH): Immunological detection and neuronal localization in the insect central nervous system, Proc. Natl Acad. Sci. U.S.A. 78:5899–5902.PubMedCrossRefGoogle Scholar
  4. Bishop, C. A., Wine, J. J., and O’Shea, M., 1984a, Neuropeptide proctolin in postural motoneurons of the crayfish, J. Neurosci. 4(8):2001–2009.PubMedGoogle Scholar
  5. Bishop, C. A., Nagy, F., Wine, J. J., and O’Shea, M., 1984b, Neural release and physiological action of an identified peptide contained in crayfish motor neurons, Soc. Neurosci. Abstr. 10:151.Google Scholar
  6. Brown, B. E., 1967, Neuromuscular transmitter substance in insect visceral muscle, Science 155:595–597.PubMedCrossRefGoogle Scholar
  7. Brown, B. E., 1975, Proctolin: A peptide transmitter candidate in insects, Life Sci. 17:1241–1252.PubMedCrossRefGoogle Scholar
  8. Brown, B. E., and Starratt, A. N., 1975, Isolation of proctolin, a myotropic peptide from Periplaneta americana, J. Insect Physiol. 21:1879–1881.CrossRefGoogle Scholar
  9. Burrows, M., and Hoyle, G., 1973, Neural mechanisms underlying behavior in the locust Schistocerca gregaria. III. Topography of limb motoneurons in the metathoracic ganglion, J. Neurobiol. 4:167–186.PubMedCrossRefGoogle Scholar
  10. Chesler, M., and Fourtner, C. R., 1981, Mechanical properties of a slow muscle in the cockroach, J. Neurobiol 12:391–402.PubMedCrossRefGoogle Scholar
  11. Eckert, M., Agricola, H., and Penzlin, H., 1981, Immunocytochemical identification of proctolinlike immunoreactivity in the terminal ganglion and hindgut of the cockroach Periplaneta americana (L)., Cell Tissue Res. 217:633–645.PubMedCrossRefGoogle Scholar
  12. Evans, P. D., and O’Shea, M., 1977, An octopaminergic neurone modulates neuromuscular transmission in the locust, Nature (London) 270:257–259.CrossRefGoogle Scholar
  13. Evans, P. D., and O’Shea, M., 1978, Identification of an octopaminergic neurone and the modulation of a myogenic rhythm in the locust, J. Exp. Biol. 73:235–260.PubMedGoogle Scholar
  14. Fernlund, P., and Josefsson, L., 1972, Crustacean color-change hormone: Amino acid sequence and chemical synthesis, Science 177:173–175.PubMedCrossRefGoogle Scholar
  15. Hoyle, G., 1983, Muscles and Their Neural Control, Wiley-Interscience, New York.Google Scholar
  16. Hoyle, G., and O’Shea, M., 1974, Intrinsic rhythmic contractions in insect skeletal muscle, J. Exp. Zool. 189:407–412.PubMedCrossRefGoogle Scholar
  17. Keshishian, H., and O’Shea, M., 1984, The distribution of a peptide neurotransmitter in the postem-bryonic grasshopper CNS, J. Neurosci. (in press).Google Scholar
  18. Kingan, T. G., and Titmus, M., 1983, Radioimmunologic detection of proctolin in Arthropods, Comp. Biochem. Physiol. C. 74:75–78.CrossRefGoogle Scholar
  19. Kravitz, E. A., Glusman, S., Harris-Warrick, R. M., Livingstone, M. S., Schwarz, T. L., and Goy, M. F., 1980, Amines and a peptide as neurohormones in lobster: Action on neuromuscular preparations and preliminary behavioral studies, J. Exp. Biol. 89:159–175.PubMedGoogle Scholar
  20. Lingle, C. J., 1979, The effects of acetylcholine, glutamate, and biogenic amines on muscle and neuromuscular transmission in the stomatogastric system of the spiny lobster, Panulirus interruptus, Ph.D. thesis, University of Oregon, Eugene, Oregon.Google Scholar
  21. May, T. E., Brown, B. E., and Clements, A. N., 1979, Experimental studies upon a bundle of tonic fibers in the locust extensor tibialis muscle, J. Insect Physiol. 25:169–181.CrossRefGoogle Scholar
  22. Mayer, R. J., and Candy, D. J., 1969, Control of hemolymph lipid concentration during locust flight: An adipokinetic hormone from the corpora cardiaca, J. Insect. Physiol. 15:611–620.CrossRefGoogle Scholar
  23. Miller, T., 1979, Nervous vs. neurohormonal control of insect heart beat, Am. Zool. 19:77–86.Google Scholar
  24. Miller, M. W., and Sullivan, R. E., 1981, Some effects of proctolin on the cardiac ganglion of the Maine lobster, Hommarus americanus (Milne Edwards), J. Neurobiol. 12:629–639.PubMedCrossRefGoogle Scholar
  25. O’Shea, M., and Adams, M. E., 1981, Pentapeptide (proctolin) associated with an identified neuron, Science 213:567–569.PubMedCrossRefGoogle Scholar
  26. O’Shea, M., and Bishop, C. A., 1982, Neuropeptide proctolin associated with an identified skeletal motoneuron, J. Neurosci. 2:1242–1251.PubMedGoogle Scholar
  27. O’Shea, M., and Evans, P. E., 1979, Potentiation of neuromuscular transmission by an octopaminergic neuron in the locust, J. Exp. Biol. 79:169–190.Google Scholar
  28. O’Shea, M., and Schaffer, M., 1985, Neuropeptide function: The invertebrate contribution, Annu. Rev. Neurosci. 8:171–198.PubMedCrossRefGoogle Scholar
  29. O’Shea, M., Witten, J., and Schaffer, M., 1984, Isolation and characterization of two myoactive neuropeptides: Further evidence of an invertebrate peptide family, J. Neurosci. 4:521–529.PubMedGoogle Scholar
  30. Piek, T., and Mantel, P., 1977, Myogenic contractions in locust muscle induced by proctolin and by wasp, Philanthus triangulum, venum, J. Insect Physiol. 23:321–325.CrossRefGoogle Scholar
  31. Pitman, R. M., 1984, Nervous system, in: Comprehensive Insect Physiology, Biochemistry and Pharmacology, Volume II (G. A. Kerkut, ed.), Pergamon Press, New York, pp. 000–000.Google Scholar
  32. Schooneveld, H., Tesser, G. I., Veenstra, J. A., and Romberg-Privee, H. M., 1983, Adipokinetic hormone and AKH-like peptide demonstrated in the corpora cardiaca and nervous system of Locusta migratoria by immunohistochemistry, Cell Tissue Res. 230:67–76.PubMedCrossRefGoogle Scholar
  33. Schwarz, T. L., Harris-Warrick, R. M., Glusman, S., and Kravitz, E. A., 1980, A peptide action on a lobster neuromuscular preparation, J. Neurobiol. 11:623–628.PubMedCrossRefGoogle Scholar
  34. Schwarz, T. L., Lee, G. M.-H., Siwicki, K. K., Standaert, D. G., and Kravitz, E. A., 1984, Proctolin in the lobster: The distribution, release and chemical characterization of a likely neurohormone, J. Neurosci. 4:1300–1311.PubMedGoogle Scholar
  35. Starratt, A. N., and Brown, B. E., 1975, Structure of the pentapeptide proctolin, a proposed neurotransmitter in insects, Life Sci. 17:1253–1256.PubMedCrossRefGoogle Scholar
  36. Stone, J. V., Mordue, W., Batley, K. E., and Morris, H. R., 1976, Structure of locust adipokinetic hormone, a neurohormone regulates lipid utilization during flight, Nature (London) 263:207–211.CrossRefGoogle Scholar
  37. Sullivan, R. E., 1979, A proctolin-like peptide in crab pericardial organs, J. Exp. Zool. 210:543–552.CrossRefGoogle Scholar
  38. Witten, J., Worden, M. K., Schaffer, M. H., and O’Shea, M., 1984a, New classification of insect motoneurons: Expression of different peptide transmitters, Soc. Neurosci. Abstr. 10:151.Google Scholar
  39. Witten, J., Schaffer, M. H., O’Shea, M., Carter Cook, J., Hemling, M. E., and Rinehart, K. L., 1984b, Structures of two cockroach neuropeptides assigned by fast atom bombardment mass spectometry, Biochem. Biophys. Res. Comm. (in press).Google Scholar

Copyright information

© Springer Science+Business Media New York 1985

Authors and Affiliations

  • Michael O’Shea
    • 1
  1. 1.Laboratory of NeurobiologyUniversity of GenevaGeneva 4Switzerland

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