Skip to main content

Neuropeptides and the Control of Egg-laying Behavior in Aplysia

  • Chapter
Book cover Model Neural Networks and Behavior

Abstract

The marine mollusk Aplysia is proving to be a useful experimental system for studying the roles of neuropeptides in neuronal function and their roles in the neural regulation of behavior. The main emphasis of investigations in our laboratory has been on the bag cell system, a group of peptide-secreting neuroendocrine cells that induce egg laying in Aplysia and also have profound effects on other central neurons.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arch, S., 1976, Biochemical isolation and physiological identification of the egg laying hormone in Aplysia californica, J. Gen. Physiol. 68:197–210.

    Article  PubMed  CAS  Google Scholar 

  • Arch, S., and Smock, T., 1977, Egg laying behavior in Aplysia californica, Behav. Biol. 19:45–54.

    Article  Google Scholar 

  • Arch, S., Smock, T., Gurvis, R., and McCarthy, C, 1978, Atrial gland induction of the egg-laying response in Aplysia californica, J. Comp. Physiol. A128:67–70.

    Article  Google Scholar 

  • Arch, S., Lupatkin, J., Smock, T., and Beard, M., 1980, Evidence for an exocrine function of the Aplysia atrial gland, J. Comp. Physiol. A141:131–137.

    Article  CAS  Google Scholar 

  • Berry, R. W., 1981, Proteolytic processing in the biogenesis of the neurosecretory egg-laying hormone in Aplysia. 1. Precursors, intermediates and products, Biochemistry 20:6200–6205.

    Article  PubMed  CAS  Google Scholar 

  • Blankenship, J. E., and Haskins, J. T., 1979, Electrotonic coupling among neuroendocrine cells in Aplysia, J. Neurophysiol. 42:347–355.

    PubMed  CAS  Google Scholar 

  • Branton, W. D., Mayeri, E., Brownell, P., and Simon, S. B., 1978a, Evidence for local hormonal communication between neurones in Aplysia, Nature (London) 274:70–72.

    Article  CAS  Google Scholar 

  • Branton, W. D., Arch, S., Smock, T., and Mayeri, E., 1978b, Evidence for mediation of a neuronal interaction by a behaviorally active peptide, Proc. Natl. Acad. Sci. U.S.A. 75:5732–5736.

    Article  PubMed  CAS  Google Scholar 

  • Brownell, P., and Mayeri, E., 1979, Prolonged inhibition of neurons by neuroendocrine cells in Aplysia, Science 204:417–420.

    Article  PubMed  CAS  Google Scholar 

  • Brownell, P. H., and Schaefer, M. E., 1982, Activation of a long-lasting motor program by bag cell neurons in Aplysia, Neurosci. Abstr. 8:736.

    Google Scholar 

  • Chiu, A. Y., and Strumwasser, F., 1981, An immunohistochemical study of the neuropeptide bag cells of Aplysia, J. Neurosci. 1:812–826.

    PubMed  CAS  Google Scholar 

  • Chiu, A. Y., Hunkapiller, M. W., Heller, E., Stuart, D. K., Hood, L. E., and Strumwasser, F., 1979, Purification and primary structure of the neuropeptide egg-laying hormone of Aplysia californica, Proc. Natl. Acad. Sci. U.S.A. 76:6656–6660.

    Article  PubMed  CAS  Google Scholar 

  • Cobbs, J. S., and Pinsker, H. M., 1982a, Role of bag cells in egg deposition of Aplysia brazilliana. I. Comparison of normal and elicited behaviors, J. Comp. Physiol. 147:523–535.

    Article  Google Scholar 

  • Cobbs, J. S., and Pinsker, H. M., 1982b, Role of bag cells in egg deposition of Aplysia braziliana. II. Contribution of egg movement to elicited behaviors J. Comp. Physiol. 147:537–546.

    Article  Google Scholar 

  • Dale, H. H., Feldberg, W., and Vogt, M., 1936, Release of acetylcholine at voluntary motor nerve endings J. Physiol. 86:353–380.

    PubMed  CAS  Google Scholar 

  • Dismukes, R. K., 1979, New concepts of molecular communication among neurons, Behav. Brain Sci. 2:409–448.

    Article  Google Scholar 

  • Frazier, W. T., Kandel, E. R., Kupfermann, I., Waziri, R., and Coggeshall, R. E. 1967, Morphological and functional properties of identified neurons in the abdominal ganglion of Aplysia californica, J. Neurophysiol. 30:1288–1351.

    Google Scholar 

  • Gainer, H., Loh, Y. P., and Same, J. Y., 1977, Biosynthesis of neuronal peptides, in: Peptides in Neurobiology (H. Gainer, ed.), Plenum Press, New York, pp. 183–219.

    Chapter  Google Scholar 

  • Glitsch, H. G., and Pott, L., 1978, Effects of acetylcholine and parasympathetic nerve stimulation on membrane potential in quiescent guinea-pig atria J. Physiol. 279:655–668.

    PubMed  CAS  Google Scholar 

  • Hartzell, H. C, Kuffler, S. W., and Yoshikami, D., 1975, Postsynaptic potentiation: Interaction between quanta of acetylcholine at the skeletal neuromuscular synapse J. Physiol. (London) 251:427.

    CAS  Google Scholar 

  • Haskins, J. T., Price, C. H., and Blankenship, J. E., 1981, A light and electron microscope investigation of the neurosecretory bag cells of Aplysia, J. Neurocytol. 10:729–747.

    Article  PubMed  CAS  Google Scholar 

  • Heller, E., Kaczmarek, L. K., Hunkapiller, M. W., Hood, L. E., and Strumwasser, F., 1980, Purification and primary structure of two neuroactive peptides that cause bag cell afterdischarge and egg-laying in Aplysia, Proc. Natl. Acad. Sci. U.S.A. 77:2328–2332.

    Article  PubMed  CAS  Google Scholar 

  • Herbert, E., Birnberg, N., Lissitsky, J-C., Ciuelli, O., and Uhler, M., 1981, Proopiomelanocortin: A model for the regulation of expression of neuropeptides in pituitary and brain, Neurosci. Comment. 1:16–27.

    Google Scholar 

  • Kandel, E. R., 1976, Cellular Basis of Behavior, Freeman, San Francisco, California.

    Google Scholar 

  • Kupfermann, I., 1967, Stimulation of egg laying: Possible neuroendocrine function of bag cells of abdominal ganglion of Aplysia californica, Nature (London) 216:814–815.

    Article  CAS  Google Scholar 

  • Kupfermann, I., and Kandel, E. R., 1970, Electrophysiological properties and functional interconnections of two symmetrical neurosecretory clusters (bag cells) in abdominal ganglion of Aplysia, J. Neurophysiol. 33:865–876.

    PubMed  CAS  Google Scholar 

  • Loewi, O., 1921, Uber humorale Ubertragbarkeit der Herznerven Wirkung. I. Mitteilung Pflueger s Arch. Ges. Physiol. 189:239–242.

    Article  Google Scholar 

  • Mayeri, E., 1979, Local hormonal modulation of neural activity in Aplysia, (FASEB Symposium on “Modulation of Synaptic Excitability”), Fed. Proc. 38:2103–2108.

    PubMed  CAS  Google Scholar 

  • Mayeri, E., and Rothman, B. S., 1982a, Nonsynaptic peptidergic neurotransmission in the abdominal ganglion of Aplysia, in: Neurosecretion—Molecules, Cells and Systems (D. S. Farner and K. Lederis, eds.), Plenum Press, New York, pp. 307–318.

    Google Scholar 

  • Mayeri, E., and Rothman, B. S., 1982b, Peptide effects on mollusckan neurons, in: Strategies for Studying the Roles of Peptides in Neuronal Function (J. L. Barker, ed.), Short Course Syllabus, Society for Neuroscience, Bethesda, Maryland, pp. 121–130.

    Google Scholar 

  • Mayeri, E., and Simon, S., 1975, Modulation of synaptic transmission and burster neuron activity after release of a neurohormone in Aplysia, Neurosci. Abstr. 1:584.

    Google Scholar 

  • Mayeri, E., Brownell, P. H., Branton, W. D., and Simon, S. B., 1979a, Multiple, prolonged actions of neuroendocrine bag cells on neurons in Aplysia. I. Effects on bursting pacemaker neurons, J. Neurophysiol. 42:1165–1184.

    PubMed  CAS  Google Scholar 

  • Mayeri, E., Brownell, P. H., and Branton, W. D., 1979b, Multiple, prolonged actions of neuroendocrine bag cells on neurons in Aplysia. II. Effects on beating pacemaker and silent neurons, J. Neurophysiol. 42:1185–1197.

    PubMed  CAS  Google Scholar 

  • Mayeri, E., Rothman, B. S., Brownell, P., Branton, W. D., and Padgett, L., 1985, Nonsynaptic characteristics of neurotransmission mediated by ELH in the abdominal ganglion of Aplysia, f. Neurosci. (in press).

    Google Scholar 

  • Pinsker, H. M., and Dudek, F. E., 1977, Bag cell control of egg-laying in freely-behaving Aplysia, Science 197:490–493.

    Article  PubMed  CAS  Google Scholar 

  • Rothman, B. S., Brown, R. O., Mayeri, E., and Shively, J. E., 1982, Isolation of novel, neuroactive ELH-like peptides from the atrial gland of Aplysia, Soc. Neurosci. Abstr. 8:14.

    Google Scholar 

  • Rothman, B. S., Mayeri, E., and Scheller, R. H., 1984, The bag cell neurons of Aplysia as a possible peptidergic multitransmitter system: From genes to behavior, in: Gene Expression in Brain (C. Zomzely-Neurath and W. A. Walker, eds.), Wiley and Sons, New York.

    Google Scholar 

  • Rothman, B. S., Weir, G., and Dudek, F. E., 1983b, Egg-laying hormone: Direct action on the ovotesis of Aplysia, Gen. Comp. Endocrinol. 52:134–141.

    Article  PubMed  CAS  Google Scholar 

  • Rothman, B. S., Mayeri, E., and Scheller, R. H., 1984, The bag cell neurons of Aplysia as a possible peptidergic multitransmitter system: From genes to behavior, in: Gene Expression in Brain (C. Zomzely-Neurath and W. A. Walker, eds.), Wiley and Sons, New York.

    Google Scholar 

  • Scheller, R. H., Jackson, J. F., McAllister, L. B., Schwartz, J. H., Kandel, E. R., and Axel, R., 1982, A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia, Cell 28:707–719.

    Article  CAS  Google Scholar 

  • Scheller, R. H., Jackson, J. F., McAllister, L. B., Rothman, B. S., Mayeri, E., and Axel, R., 1983a, A single gene encodes multiple neuropeptides mediating a stereotyped behavior, Cell 32:7–22.

    Article  PubMed  CAS  Google Scholar 

  • Scheller, R. H., Rothman, B. S., and Mayeri, E., 1983b, A single gene encodes multiple peptide neurotransmitter candidates involved in a stereotyped behavior, Trends Neurosci. 6:340–345.

    Article  CAS  Google Scholar 

  • Sigvardt, K., Rothman, B. S., and Mayeri, E., 1983, Analysis of inhibition produced by the candidate neurotransmitter, α-bag cell peptide, in identified neurons of Aplysia, Soc. Neurosci. Abstr. 9:311.

    Google Scholar 

  • Sigvardt, K. A., Rothman, B. S., Brown, R. O., and Mayeri, E., 1984, The bag cells of Aplysia as a multitransmitter system: identification of alpha bag cell peptide as a second neurotransmitter (submitted).

    Google Scholar 

  • Stuart, D. K., and Strumwasser, F., 1980, Neuronal sites of action of a neurosecretory peptide, egg-laying hormone, in Aplysia californica, J. Neurophysiol. 43:499–519.

    PubMed  CAS  Google Scholar 

  • Tinbergen, N., 1951, The Study of Instinct, Oxford University Press, New York.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer Science+Business Media New York

About this chapter

Cite this chapter

Mayeri, E., Rothman, B.S. (1985). Neuropeptides and the Control of Egg-laying Behavior in Aplysia . In: Selverston, A.I. (eds) Model Neural Networks and Behavior. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5858-0_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-5858-0_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5860-3

  • Online ISBN: 978-1-4757-5858-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics