Oxidative Stress, Caveolae and Caveolin-1

  • Marie-Odile Parat
  • Paul L. Fox
Part of the Subcellular Biochemistry book series (SCBI, volume 37)


Oxidative stress underlies a range of pathophysiological conditions. Reactive oxygen species are also generated intracellularly to serve as second messengers and some are linked to caveolae/raft signalling systems. The effect of oxidative stress on caveolin-1 expression, post-translational modifications, membrane trafficking and function are described.


Reactive Oxygen Species Nitric Oxide Tyrosine Phosphorylation Cholesterol Oxidase Bovine Aortic Endothelial Cell 
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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • Marie-Odile Parat
    • 1
  • Paul L. Fox
    • 1
  1. 1.Departments of Anesthesiology Research and Cell Biology, The Lerner Research InstituteCleveland Clinic FoundationClevelandUSA

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