Skip to main content
SpringerLink
Log in

Structure and Regulation of the Human IL-2 Receptor

  • Chapter
Mechanisms of Lymphocyte Activation and Immune Regulation II

  • 53 Accesses

Abstract

The growth of human T lymphocytes can be divided into two discrete stages resembling competence and progression. In the first stage, the binding of antigen or mitogen to specific T cell receptors triggers the transduction of intracellular signals leading to cellular activation1,2. In turn, these activation signals induce the de novo expression of genes mediating T cell growth including interleukin-2 (IL-2) and interleukin-2 receptors (IL-2R)3–5. The subsequent binding of IL-2 to its high affinity receptor promotes proliferation and clonal expansion of the cells originally stimulated by antigen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. A. Weiss, J. Imboden, D. Schoback, and J. Stobo. 1984. Role of T3 surface molecules in the activation of human T cells: T3 dependent activation results in a rise in cytoplasmic free calcium. Proc. Natl. Acad. Sci. USA 81: 4169–4173.

    Google Scholar 

  2. A. Weiss and J.B. Imboden. 1987. Cell surface molecules and early events involved in human T lymphocyte activation. Adv. Immunol. 41: 1–38.

    Article  PubMed  CAS  Google Scholar 

  3. T. Taniguchi, H. Matsui, T. Fujita, M. Hatakeyama, N. Kashima, A. Fuse, J. Hamuro, C. Nishi-Takaoka and G. Yamada. 1986. Molecular analysis of the interleukin-2 and its cellular receptor. Prog. Hematol. 14: 283–301.

    Google Scholar 

  4. W.C. Greene, W.J. Leonard, and J.M. Depper. 1986. Growth of human T lymphocytes: an analysis of interleukin-2 and its cellular receptor. Prog. Hematol. 14: 283–301.

    PubMed  CAS  Google Scholar 

  5. K.A. Smith. 1984. Interleukin 2. Ann. Rev. Immunol. 2: 319–333.

    Article  CAS  Google Scholar 

  6. W.J. Leonard, J.M. Depper, R.J. Robb, T.A. Waldmann, and W.C. Greene. 1982. A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor. Nature 300: 267–269.

    Article  PubMed  CAS  Google Scholar 

  7. R.J. Robb and W.C. Greene. 1983. Direct demonstration of the identity of T cell growth factor binding protein and the Tac antigen. J. Exp. Med. 158: 1332–1337.

    Article  PubMed  CAS  Google Scholar 

  8. M. Sharon, R.D. Klausner, B.R. Cullen, R. Chizzonite and W.J. Leonard. 1986. Novel interleukin-2 receptor subunit detected by cross-linking under high-affinity conditions. Science 234: 859–863.

    Article  PubMed  CAS  Google Scholar 

  9. M. Tsudo, R.W. Kozak, C.K. Goldman, and T.A. Waldmann. 1986. Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex. Proc. Natl. Acad. Sci. 83: 9694–9698.

    Article  PubMed  CAS  Google Scholar 

  10. K. Teshigawara, H.M. Wang, K. Kato and K.A. Smith. 1987. Interleukin 2 high-affinity receptor expression requires two distinct binding proteins. J. Exp. Med. 165: 223–238.

    Article  PubMed  CAS  Google Scholar 

  11. R.J. Robb, C.M. Rusk, J. Yodoi and W.C. Greene. 1987. Interleukin 2 binding molecule distinct from the Tac protein: analysis of its role in formation of high-affinity receptors. Proc. Natl. Acad. Sci. 84: 2002–2006.

    Article  PubMed  CAS  Google Scholar 

  12. M. Dukovich, Y. Wano, L. Thuy, P. Katz, B.R. Cullen, J.H. Kehrl and W.C. Greene. 1987. A second human interleukin-2 binding protein that may be a component of high-affinity interleukin-2 receptors. Nature 327: 518–522.

    Article  PubMed  CAS  Google Scholar 

  13. M. Fujii, K. Sugamura, K. Sano, M. Nakai, K. Sugita and Y. Hinuma. 1986. High-affinity receptor mediated internalization and degradation of interleukin 2 in human T cells. J. Exp. Med. 163: 550–555.

    Article  PubMed  CAS  Google Scholar 

  14. J.W. Lowenthal, and W.C. Greene. 1987. Contrasting interleukin 2 binding properties of the a (p55) and ß (p70) protein subunits of the human high affinity interleukin 2 receptor. J. Exp. Med. 166: 1156–1161.

    Article  PubMed  CAS  Google Scholar 

  15. H.-M. Wang, and K.A. Smith. 1987. The interleukin 2 receptor: functional consequences of its bimolecular structure. J. Exp. Med. 166: 1055–1069.

    Article  PubMed  CAS  Google Scholar 

  16. R.J. Robb, and W.C. Greene. 1987. Internalization of interleukin 2 is mediated by the ß chain of the high affinity interleukin 2 receptor. J. Exp. Med. 165: 1202–1212.

    Article  Google Scholar 

  17. W.J. Leonard, J.M. Depper, G.R. Crabtree, S. Rudikoff, J. Pumphrey, R. Robb, M. Kronke, P.B. Svetlik, N.J. Peffer, T.A. Waldmann and W.C. Greene. 1984. Molecular cloning and expression of cDNAs for the human interleukin-2 receptor. Nature 311: 626–631.

    Article  PubMed  CAS  Google Scholar 

  18. Le thi Bich-Thuy, M. Dukovich, N.J. Peffer, A.S. Fauci, J.H. Kehrl and W.C. Greene. 1987. Direct activation of human T cells by IL-2: the role of an IL-2 receptor distinct from the Tac protein. J. Immunol. 139 (5): 1550–1556.

    Google Scholar 

  19. M. Tsudo, C.K. Goldman, K.F. Bongiovanni, W.C. Chan, E.F. Winton, M. Yagita, E.A. Grimm and T.A. Waldmann. 1987. The p75 peptide is the receptor for interleukin 2 expressed on large granular lymphocytes and is responsible for the interleukin 2 activation of these cells. Proc. Natl. Acad. Sci. USA. 84: 5394–8.

    Article  PubMed  CAS  Google Scholar 

  20. J.P. Siegel, M. Sharon, P.L. Smith and W.J. Leonard. 1987. The IL-2 receptor beta chain (p70): role in mediating signals for LAK, NK, and proliferative activities. Science 238: 75–78.

    Article  PubMed  CAS  Google Scholar 

  21. J.H. Kehrl, M. Dukovich, G. Whalen, P. Katz, A.S. Fauci and W.C. Greene. 1988. Novel interleukin-2 (IL-2) receptor appears to mediate IL-2 induced activation of natural killer cells. J. Clinical. Invest. 81: 200–205.

    Article  CAS  Google Scholar 

  22. M. Maruyama, H. Shibuya, H. Harada, M. Hatakeyama, M. Seiki, T. Fujita, J. Inoue, M. Yoshida and T. Taniguchi. 1987. Evidence for aberrant activation of the interleukin-2 autocrine loop by HTLV-I-encoded p40x and T3/Ti complex triggering. Cell 48: 343–350.

    Article  PubMed  CAS  Google Scholar 

  23. S.L. Cross, M.B. Feinberg, J.B. Wolf, N.J. Holbrook. F. Wong-Staal and W.J. Leonard. 1987. Regulation of the human interleukin-2 receptor chain promoter: activation of a nonfunctional promoter by the transactivator gene of HTLV I. Cell 49: 47–56.

    Article  PubMed  CAS  Google Scholar 

  24. N. Suzuki, N. Matsunami, H. Kanamori, N. Ishida, A. Shimizu, Y. Yaoita, T. Nikaido and T. Honjo. 1987. The human IL-2 receptor gene contains a positive regulatory element that functions in cultured cells and cell-free extracts. J. Biol. Chem. 262: 5079–5086

    PubMed  CAS  Google Scholar 

  25. J.W. Lowenthal, E. Böhnlein, D.W. Ballard and W.C. Greene. 1988. Regulation of IL-2 receptor a subunit (Tac) gene expression: binding of inducible nuclear proteins to discrete promoter sequences correlates with transcriptional activation. Proc. Natl. Acad. Sci. USA 85: 4468–4472.

    Article  PubMed  CAS  Google Scholar 

  26. E. Böhnlein, E., J.W. Lowenthal, M. Siekevitz, D.W. Ballard, B.R. Franza and W.C. Greene. 1988. The same inducible transcription factor regulates mitogen induced activation of the interleukin-2 receptor gene and type 1 human immunodeficiency virus. Cell 53: 827–836.

    Google Scholar 

  27. G. Nabel and D. Baltimore. 1987. An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature 326: 711–783.

    Article  PubMed  CAS  Google Scholar 

  28. R.B. Franza, S.F. Josephs, M.Z. Gilman, W. Ryan and B. Clarkson. 1987. Characterization of cellular proteins recognizing the HIV enhancer using a microscale DNA-affinity precipitation assay. Nature 330: 391–395.

    Article  PubMed  CAS  Google Scholar 

  29. M. Siekevitz, M., S.F. Josephs, M. Dukovich, N. Peffer, F. Wong-Staal and W.C. Greene. 1987b. Activation of the HIV-1 LTR by T-cell mitogens and the tax-I protein of HTLV-I. Science 238: 1575–1578.

    CAS  Google Scholar 

  30. J.D. Kaufman, G. Valandra, G. Rodriguez, G. Bushar, C. Giri and M.D. Norcross. 1987. Phorbol ester enhances human immunodeficiency virus-promoted gene expression and acts on a repeated 10-base-pair functional enhancer element. Molec. Cell Biol. 7: 3759–3766.

    CAS  Google Scholar 

  31. S.E. Tong-Starksen, P.A. Luciw and B.M. Peterlin. Human immunodeficiency virus long terminal repeat responds to T-cell activation signals. Proc. Natl. Acad. Sci. 84: 6845–6849.

    Article  Google Scholar 

  32. M. Siekevitz, M.B. Feinberg, N. Holbrook, J. Yodoi, F. Wong-Staal and W.C. Greene. 1987a. Activation of interleukin-2 and interleukin-2 receptor (Tac) promoter expression by the trans-activator (tax) gene product of human T-cell leukemia virus, type I. Proc. Natl. Acad. Sci. 84: 5389–5393.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Howard Hughes Medical Institute, Duke University Medical Center, Box 3037, Durham, North Carolina, USA

    Warner C. Greene, Ernst Böhnlein, Dean W. Ballard & John W. Lowenthal

  2. Mt. Sinai Medical Center, One Gustave Levy Place, New York, New York, USA

    Miriam Siekevitz

  3. Cold Spring Harbor Laboratory, P.O. Box 534, Cold Spring Harbor, New York, USA

    B. Robert Franza

Authors
  1. Warner C. Greene
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ernst Böhnlein
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Miriam Siekevitz
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Dean W. Ballard
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Robert Franza
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. John W. Lowenthal
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Basic and Clinical Immunology, University of California, Irvine, 92717, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer Science+Business Media New York

About this chapter

Cite this chapter

Greene, W.C., Böhnlein, E., Siekevitz, M., Ballard, D.W., Franza, B.R., Lowenthal, J.W. (1989). Structure and Regulation of the Human IL-2 Receptor. In: Gupta, S., Paul, W.E. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5803-0_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4757-5803-0_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5805-4

  • Online ISBN: 978-1-4757-5803-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation