Structure and Regulation of the Human IL-2 Receptor

  • Warner C. Greene
  • Ernst Böhnlein
  • Miriam Siekevitz
  • Dean W. Ballard
  • B. Robert Franza
  • John W. Lowenthal


The growth of human T lymphocytes can be divided into two discrete stages resembling competence and progression. In the first stage, the binding of antigen or mitogen to specific T cell receptors triggers the transduction of intracellular signals leading to cellular activation1,2. In turn, these activation signals induce the de novo expression of genes mediating T cell growth including interleukin-2 (IL-2) and interleukin-2 receptors (IL-2R)3–5. The subsequent binding of IL-2 to its high affinity receptor promotes proliferation and clonal expansion of the cells originally stimulated by antigen.


Human Immunodeficiency Virus Jurkat Cell Thymidine Kinase Promoter Intermediate Affinity Kappa Light Chain Immunoglobulin 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Warner C. Greene
    • 1
  • Ernst Böhnlein
    • 1
  • Miriam Siekevitz
    • 2
  • Dean W. Ballard
    • 1
  • B. Robert Franza
    • 3
  • John W. Lowenthal
    • 1
  1. 1.Howard Hughes Medical InstituteDuke University Medical CenterDurhamUSA
  2. 2.Mt. Sinai Medical CenterNew YorkUSA
  3. 3.Cold Spring Harbor LaboratoryCold Spring HarborUSA

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