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Interleukin-1 Induced T-Lymphocyte Proliferation and Its Relation to IL-1 Receptors

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Book cover Mechanisms of Lymphocyte Activation and Immune Regulation II

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Abstract

Interleukin-1 (IL-1) is a polypeptide cytokine which possesses several biological properties including lymphocyte activation, fever, endothelial cell stimulation and mesenchymal tissue remodeling (reviewed in 1). In lymphocytes, fibroblasts, endothelial cells, and macrophages, IL-1 induces a variety of immunomodulatory molecules, such as more IL-2, granulocyte-macrophage colony stimulating factor, IL-6, and IL-1 itself.2 Many of the biological properties of IL-1 are also observed with another polypeptide cytokine, tumor necrosis factor (TNF)3; however, IL-1 and TNF have distinct primary structures and cell receptors. IL-1 receptors are most numerous on fibroblasts4 and T-cell lines.5–7 These include the EL4 murine thymoma and LBRM line. The IL-1 cell surface binding protein (receptor) recognizes both beta and alpha forms of IL-I has been demonstrated on several lymphocyte-derived cell lines as well as mature, circulating blood T-cells.8

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References

  1. C.A. Dinarello, The biology of interleukin-1, FASEB J 2: 108 (1988).

    Google Scholar 

  2. C.A. Dinarello, T. Ikejima, S.J.C. Warner, S.F. Orencole, G. Lonnemann, J.G. Cannon, and P. Libby, Interleukin-1 induces interleukin-1. I. Induction of circulating interleukin-1 in rabbits in vivo and in human mononuclear cells in vitro J immunol 139: 1902 (1987).

    CAS  Google Scholar 

  3. B. Beutler and A. Cerami, Cachectin and tumor necrosis factor as two sides of the same biolocial coin, Nature 320: 584 (1986).

    CAS  Google Scholar 

  4. T.A. Bird, A.J.H. Gearing, and J. Saklatvala, Murine interleukin-1 receptor: difference in binding properties between fibroblastic and thymoma cells and evidence for a two-chain receptor model, FEBS Lett 225: 21 (1987).

    CAS  Google Scholar 

  5. P.O. Kilian, K.L. Kaffka, A.S. Stern, D. Woehle, W.R. Benjamin, T.M. DeChiara, U. Gubler, J.J. Farrar, S.B. Mizel, and P.T. Lomedico, Interleukin-1-alpha and interleukin-1-beta bind to the same receptor on T cells, J Immunol 136: 4509 (1986).

    CAS  Google Scholar 

  6. J.W. Lowenthal and H.R. MacDonald, Binding and internalization of interleukin-1 by T cells. Direct evidence for high and low affinity classes of interleukin-1 receptor, J Exp Med 164: 1060 (1986).

    CAS  Google Scholar 

  7. K. Matsushima, J. Yodoi, Y. Tagaya and J.J. Oppenheim, Down-regulation of interleukin-1 (IL-1) receptor expression by IL-1 and fate of internalized 1251-labeled IL-1-beta in a human large granular lymphocyte cell line, J Immunol 137: 3183 (1986).

    PubMed  CAS  Google Scholar 

  8. F. Shirakawa, Y. Tanaka, T. Ota, H. Suzuki, S. Eto, and U. Yamashita, Expression of interleukin-1 receptors on human peripheral T cells, J Immunol 138: 4243 (1987).

    CAS  Google Scholar 

  9. S.B. Mizel, Interleukin-1 and T cell activation, Immunol Rev 63: 51 (1982).

    CAS  Google Scholar 

  10. S.K. Durum, J.A. Schmidt, and J.J. Oppenheim, Interleukin-1: an immunological perspective. Ann Rev Immunol 3: 263 (1985).

    Article  CAS  Google Scholar 

  11. T. Krakauer, D. Mizel, and J.J. Oppenheim, Independent and synergistic thymocyte proliferative activities of PMA and IL-1, J. Immunol. 129:939 (1982).

    Google Scholar 

  12. P.L. Simon, Calcium mediates one of the signals required for interleukin-1 and 2 production by murine cell lines, Cell Immunol 87: 720 (1984).

    CAS  Google Scholar 

  13. K.A. Smith, L.B. Lachman, J.J. Oppenheim, and M.F. Favata, The functional relationship of the interleukins J Exp Med 151: 1551 (1980).

    CAS  Google Scholar 

  14. J.M. Williams, D. DeLoria, J.A. Hansen, C.A. Dinarello, R. Loertxcher, H.M. Shapiro, and T.B. Strom, The events of primary T cell activation can be staged by use of sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin-1, J. Immunol. 135:2249 (1985).

    Google Scholar 

  15. J. Kaye, S. Gillis, S.B. Mizel, E.M. Shevach, T.R. Malek, C.A. Dinarello, L.B. Lachman, and C.A. Janeway, Jr., Growth of a cloned helper T-cell line induced by a monoclonal antibody specific for the antigen receptor: interleukin-1 is required for the expression of receptors for interleukin-2. J. Immunol. 133:1339 (1984).

    Google Scholar 

  16. A.H. Lichtman, E.A. Kurt-Jones, and A.K. Abbas, B cell stimulatory factor 1 and not interleukin-2 is the autocrine growth factor for some helper T lymphocytes, Proc. Natl. Acad. Sci. USA 84:824 (1987).

    Google Scholar 

  17. T. Kupper, M. Horowitz, F. Lee, R. Robb and P.M. Flood, Autocrine growth of T cells independent of interleukin-2: identification of interleukin-4 (IL-4, BSF-1) as an autocrine growth factor for a cloned antigen-specific helper T cell. J. Immunol. 138: 4280.

    Google Scholar 

  18. T. Kupper, P. Flood, D. Coleman, and M. Horowitz, Growth of an interleukin 2/interleukin 4-dependent T cell line induced by granulocyte-macrophage colony-stimulating factor (GM-CSF), J. Immunol. 138:4288 (1987).

    Google Scholar 

  19. G. Lonnemann, S. Endres, J.W.M. van der Meer, J.G. Cannon, and C.A. Dinarello, A radioimmunoassay for production from human mononuclear cells. Lymphokine Res. (in press).

    Google Scholar 

  20. J. Ohara and W.E. Paul, Production of a monoclonal antibody to and molecular characterization of B-cell stimulating factor-1, Nature 315: 333 (1985).

    CAS  Google Scholar 

  21. A. Billiau, BSF-2 is not just a differentiation factor, Nature 324: 415 (1986).

    PubMed  CAS  Google Scholar 

  22. J.W. Lowenthal, J.-C. Cerottini, and H.R. MacDonald, Interleukin-1 dependent induction of both interleukin-2 secretion and interleukin-2 receptor expression by thymoma cells, J Immunol 137: 1226 (1986).

    CAS  Google Scholar 

  23. B. Tartakovsky, E.J. Kovacs, L. Takacs, and S.K. Durum, T cell clone producing an IL-1-like activity after stimulation by antigen-presenting B cells. J. Immunol. 137:160 (1986).

    Google Scholar 

  24. D.L. Lacey, J. Axelrod, J.C. Chappel, A.J. Kahn, and S.L. Teitelbaum, Vitamin D affects proliferation of a murine T helper cell clone, J. Immunol. 138:1680 (1987).

    Google Scholar 

  25. D.L. Ennist, K.L. Elkins, S.C. Cheng, and M. Howard, Activity of a partially purified human BCGF on murine assays for B cell stimulatory factors. II. Synergy between two distinct BCGF II-like factors in promoting B cell differentiation, J. Immunol. 139: 1525 (1987).

    PubMed  CAS  Google Scholar 

  26. S. Ho, R.T. Abraham, A. Nilson, B.S. Handwerger, and D.J. McKean, Interleukin-lmediated activation of interleukin-4 producing T lymphocytes. Proliferation by IL-4-dependent and IL-4-independent mechanisms. J. Immunol. 139:1532 (1987).

    Google Scholar 

  27. A.H. Lichtman, M.E. Williams, J. Ohara, W.E. Paul, D.V. Faller, and A.K. Abbas, Retrovirus infection alters growth factor responses of T lymphocytes, L Immunol. 138: 3276 (1987).

    CAS  Google Scholar 

  28. D.L. Lacey, J.C. Chappel, S.L. Teitelbaum, Interleukin-1 stimulates proliferation of a nontransformed T lymphocyte line in the absence of co-mitogen, J. Immunol. 139:2649 (1987).

    Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Medicine, Tufts University School of Medicine and New England Medical Center Hospital, Boston, MA, 02111, USA

    Charles A. Dinarello, Scott F. Orencole & Nerina Savage

  2. Department of Medical Biochemistry, Medical School, University of the Witwatersrand Johannesburg, South Africa

    Charles A. Dinarello, Scott F. Orencole & Nerina Savage

Authors
  1. Charles A. Dinarello
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  2. Scott F. Orencole
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  3. Nerina Savage
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Editor information

Editors and Affiliations

  1. Division of Basic and Clinical Immunology, University of California, Irvine, 92717, Irvine, California, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases National Institutes of Health, Bethesda, Maryland, USA

    William E. Paul

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© 1989 Springer Science+Business Media New York

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Dinarello, C.A., Orencole, S.F., Savage, N. (1989). Interleukin-1 Induced T-Lymphocyte Proliferation and Its Relation to IL-1 Receptors. In: Gupta, S., Paul, W.E. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation II. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-5803-0_6

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  • DOI: https://doi.org/10.1007/978-1-4757-5803-0_6

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4757-5805-4

  • Online ISBN: 978-1-4757-5803-0

  • eBook Packages: Springer Book Archive

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