Use of Somatic Cell Mutants to Study the Signal Transduction Function of the T Cell Antigen Receptor

  • Mark A. Goldsmith
  • Linda K. Bockenstedt
  • Paul Dazin
  • Arthur Weiss


The activation of thymus-derived lymphocytes (T cells) is regulated by cell surface molecules that may function in a stimulatory or inhibitory manner. Among the many plasma membrane proteins that have been implicated in T cell functional activities, the antigen receptor plays a central role in initiating T cell activation during an immune response. Upon appropriate interaction with antigen or anti-receptor antibodies that have been used to mimic antigen, the T cell receptor induces transmembrane signalling events that contribute to the subsequent cellular response. Such cellular activation is most commonly manifested by the appearance of cytolytic activity, production of lymphokines or proliferation of T cells.


Jurkat Cell Phorbol Myristate Acetate Antigen Receptor Inositol Phosphate Transmembrane Signalling 
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Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Mark A. Goldsmith
    • 1
  • Linda K. Bockenstedt
    • 1
  • Paul Dazin
    • 1
  • Arthur Weiss
    • 1
  1. 1.Departments of Medicine and of Microbiology and Immunology Howard Hughes Medical InstituteUniversity of California, San FranciscoSan FranciscoUSA

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