Normal and Abnormal Regulation of Human B Cell Differentiation by a New Cytokine, BSF2/IL-6

  • Tadamitsu Kishimoto
  • Tetsuya Taga
  • Katsuhiko Yamasaki
  • Tadashi Matsuda
  • Bo Tang
  • Atsushi Muraguchi
  • Yasuhiro Horii
  • Sachiko Suematsu
  • Yuichi Hirata
  • Hideo Yawata
  • Masatoshi Shimizu
  • Michiaki Kawano
  • Toshio Hirano

Abstract

Antibody molecules play an essential role not only in protection against viral or bacterial infections, but also in the induction of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus, and immediate-type hypersensitivity. Therefore, the study of the mechanism regulating the activation, proliferation and immunoglobulin secretion of B lymphocytes is essential for the normal and abnormal regulations in the antibody response.

Keywords

Multiple Myeloma Myeloma Cell Acute Phase Protein Acute Phase Reaction Myeloma Cell Line 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    T. Kishimoto, Factors affecting B-cell growth and differentiation, Ann. Rev. Immunol 3:133 (1985).Google Scholar
  2. 2.
    Y. Noma, T. Sideras, T. NAito, A. Bergstedt-Lindqvist, C. Azuma, E. Severinson, T. Tanabe, T. Kinashi, F. Matsuda, Y. Yaoita, and T. Honjo, Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter. Nature 319: 640 (1986).Google Scholar
  3. F. Lee, T. Yokota, T. Otsuka, P. Meyerson, D. Villaret, N. Rocham, C. Smith, A. Zlotnick, and K. Arai, Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell and mast cell-stimulating activities. Proc. Natl. Acad. Sci.. USA 83:2061 (1986).Google Scholar
  4. 4.
    T. Kinashi, N. Harada, E. Severinson, R. Tanabe, P. Sideras, M. Konishi, C. Azuma, A. Tominaga, S. Bergstedt-Lindqvist, M. Takahashi, F. Matsuda, Y. Yaoita, K. Takatsu, and T. Honjo, Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor H. Nature 324: 70 (1986).Google Scholar
  5. 5.
    T. Hirano, K. Yasukawa, H. Harada, T. Taga, Y. Watanabe, T. Matsuda, S. Kashiwamura, K. Nakajima, K. Koyama, A. Iwamatsu, S. Tsunasawa, F. Sakiyama, H. Matsui, Y. Takahara, T. Taniguchi, and T. Kishimoto, Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin. Nature 324: 73 (1986).Google Scholar
  6. T. Kishimoto and T. Hirano, Molecular regulation of B lymphocyte response. Ann. Rev. Immunol 6:485 (1988).Google Scholar
  7. 7.
    J. Gauldie, C. Richards, D. Harnish, P. Lansdorp, and H. Baumann, Interferon ß2/BSF-2 shares identity with monocyte derived hepatocyte stimulating factor (HSF) and regulates the major acute phase protein response in liver cells. Proc. Natl. Acad. Sci.. USA in press (1987).Google Scholar
  8. T. Andus, T. Geiger, T. Hirano, H. Northoff, U. Ganter, J. Bauer, T. Kishimoto, and P.C. Heinrich, Recombinant human B cell stimulatory factor 2 (BSF-2/INFß2) regulates ß-fibrinogen and albumin mRNA levels in Fa0–9 cells. FEBS Lett 221:18 (1987)Google Scholar
  9. K. Ikebuchi, G.G. Wong, S.C. Clark, J.N. Ihle, Y. Hirai, and M. Ogawa, Interleukin-6 enhancement of interleukin-3-dependent proliferation of multipotential hemopoietic progenitors. Proc. Natl. Acad. Sci., USA 84:9035 (1987).Google Scholar
  10. 10.
    M. Lotz, F. Jirik, R. Kabouridis, C. Tsoukas, T. Hirano, T. Kishimoto, and D.A. Carson. BSF-2/IL-6 is a costimulant for human thymocytes and T lymphocytes. J. Exp. Med in press (1988).Google Scholar
  11. A. Muraguchi, T. Kishimoto, Y. Miki, T. Kuritani, T. Kaieda, K. Yoshizaki, and Y. Yamamura, T cell-replacing factor (TRF)-induced IgG secretion in human B blastoid cell line and demonstration of acceptors for TRF. J. Immunol 127:412 (1981).Google Scholar
  12. T. Hirano, T. Taga, N. Nakano, K. Yasukawa, S. Kashiwamura, K. Shimuzu, K. Nakajima, K.H. Pyun, and T. Kishimoto, Purification to homogeneity and characterization of human B cell differentiation factor (BCDF or BSFp-2). Proc. Natl. Acad. Sci., USA 82:5490 (1985).Google Scholar
  13. 13.
    T. Hirano, T. Matsuda, K. Hosoi, A. Okano, H. Matsui, and T. Kishimoto, Absence of antiviral activity in recombinant B cell stimulatory factor 2 (BSF-2). Immunol Lett. 17: 41 (1988).PubMedGoogle Scholar
  14. A. Muraguchi, T. Hirano, B. Tang, T. Matsuda, Y. Horii, K. Nakajima, and T. Kishimoto, The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells. J. Exp. Med 167:332 (1988).Google Scholar
  15. 15.
    A. Zilberstein, R. Ruggieri, J.H. Korn, and M. Revel, Structure and expression of cDNA and genes for human interferon-beta-2, a distinct species inducible by growth-stimulatory cytokines. EMBO Journal 5: 2529 (1986).Google Scholar
  16. G. Haegeman, J. Content, G. Volckaert, R. Derynck, J. Tavernieir, and W. Fiers, Structural analysis of the sequence encoding for an inducible 26-kDa protein in human fibroblasts. Eur. J. Biochem 159: 625 (1986).Google Scholar
  17. 17.
    J. Weissenbach, Y. Chernajovsky, M. Zeevi, L. Shulman, H. Soreq, U. Nir, D. Wallach, M. Perricaudet, P. Tiollais, and M. Revel, Two interferon mRNA in human fibroblasts: In vitro translation and Escherichia coli cloning studies. Proc. Natl. Acad. Sci.. USA 77: 7152 (1980).PubMedCrossRefGoogle Scholar
  18. 18.
    P. Poupart, P. Vandenabeele, S. Cayphas, J.V. Snick, G. Haegeman, V. Kruys, W. Fiers, and J. Content, B cell growth modulating and differentiating activity of recombinant human 26-kd protein (BSF-2, HuIFN-ß2, HPGF). EMBO J 6: 1219 (1987).Google Scholar
  19. J. Van Damme, G. Opdenakker, R.J. Simpson, M.R. Rubira, S. Cayphas, A. Vink, A. Billiau, and J. Van Snick, Identification of the human 26-kD protein, interferon ß2 (IFN-ß2), as a B cell hybridoma/plasmacytoma growth factor induced by interleukin 1 and tumor necrosis factor. J. Exp. Med 165:914 (1987).Google Scholar
  20. 20.
    M. Kawano, T. Hirano, T. Matsuda, T. Taga, Y. Horii, K. Iwato, H. Asaoku, B. Tang, O. Tanabe, H. Tanaka, A. Kuramoto, and T. Kishimoto, Autocrine generation and essential requirement of BSF-2/IL-6 for human multiple myelomas. Nature in press (1988).Google Scholar
  21. 21.
    K. Yasukawa, T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, S. Nakai, and T. Kishimoto, Structure and expression of human B cell stimulatory factor 2 (BSF-2) gene. EMBO J 6: 2939 (1987).Google Scholar
  22. T. Hirano, T. Taga, K. Yasukawa, K. Nakajima, N. Nakano, F. Takatsuki, M. Shimuzu, A. Murashima, S. Tsunasawa, F. Sakiyama, and T. Kishimoto, Human B cell differentiation factor defined by an antipeptide antibody and its possible role in autoantibody production. Proc. Natl. Acad. Sci.. USA 84:228 (1987).Google Scholar
  23. 23.
    M.W. Nijsten, E.R. DeGroot, H.J. Duis, C.E. Hack, and L.A. Aarcen, Serum levels of interleukin 6 and acute phase response. Lancet ii: 921 (1987).Google Scholar
  24. 24.
    T. Taga, Y. Kawanishi, R.R. Hardy, T. Hirano, and T. Kishimoto, Receptors for B cell stimulatory factor 2 (BSF2): Quantitation, specificity, distribution andGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1989

Authors and Affiliations

  • Tadamitsu Kishimoto
    • 1
  • Tetsuya Taga
    • 1
  • Katsuhiko Yamasaki
    • 1
  • Tadashi Matsuda
    • 1
  • Bo Tang
    • 1
  • Atsushi Muraguchi
    • 1
  • Yasuhiro Horii
    • 1
  • Sachiko Suematsu
    • 1
  • Yuichi Hirata
    • 1
  • Hideo Yawata
    • 1
  • Masatoshi Shimizu
    • 1
  • Michiaki Kawano
    • 1
  • Toshio Hirano
    • 1
  1. 1.Institute for Molecular and Cellular BiologyOsaka UniversitySuita, Osaka 565Japan

Personalised recommendations